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Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis.

Abstract：

:Eighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4 in late luteal phase and 8 in 3rd and 17th day from onset of menses. Pretreatment and posttreatment laparoscopic score, performed according to the American Fertility Society scoring system, were compared; a significant reduction in the extent of disease was observed in each group investigated (A and C: p < 0.01; B: p < 0.05). In each treatment group after the second GnRH-a implant the mean levels of estrone-3-glucuronide (E1-3G), daily measured in early morning urine specimens during the control cycle and the first three months of therapy, were suppressed to menopausal women range. In group B during the 2nd and 3rd month of therapy, the urinary mean levels of E1-3G were significantly lower than in group A and C. In conclusion the different goserelin depot administration schedules gave similar laparoscopic improvement, in spite of the first GnRH-a administration in luteal phase allowed a more marked estrogenic suppression.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Magini A,Pellegrini S,Tavella K,Forti G,Massi GB,Serio M

doi

10.1007/BF03348925

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

775-80

issue

10

eissn

0391-4097

issn

1720-8386

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验

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