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Sex-dependency of hepatic alcohol metabolizing enzymes.

Abstract：

:In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of all hepatic alcohol metabolizing enzymes virtually unchanged. Ovariectomy also had little if any influence on the activity levels of the enzymes. There was a clear difference between the sexes in the hepatic alcohol metabolizing enzymes with higher enzymic activities of the microsomal ethanol oxidizing system and catalase in male than in female rats, whereas the opposite constellation was found for alcohol dehydrogenase activity. These data therefore indicate the sex-dependent nature of alcohol dehydrogenase, the hepatic microsomal ethanol oxidizing system and catalase activities in rat liver.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Teschke R,Wiese B

doi

10.1007/BF03348330

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

243-50

issue

4

eissn

0391-4097

issn

1720-8386

journal_volume

5

pub_type

杂志文章

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