Hyperhomocysteinemia: a biochemical link between bone and cardiovascular system diseases?

abstract：BACKGROUND:Diabetes mellitus is frequently observed in patients with acromegaly. Current therapies for acromegaly may impact glucose regulation, influencing insulin sensitivity and secretion. The question whether these therapies modify control and progression of diabetes once present is still open. AIM:Aim of our stud...

journal_title：Journal of endocrinological investigation

authors： Cambuli VM,Galdiero M,Mastinu M,Pigliaru F,Auriemma RS,Ciresi A,Pivonello R,Amato M,Giordano C,Mariotti S,Colao A,Baroni MG

更新日期：2012-02-01 00:00:00

abstract：:Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...

journal_title：Journal of endocrinological investigation

authors： Girelli ME,Casara D,Rubello D,Piccolo M,Piotto A,Pelizzo MR,Busnardo B

更新日期：1993-02-01 00:00:00

abstract：:Forty-eight morbidly obese patients were placed on a very low calorie (800 kcal) formula diet (OPTIFAST) for a 10-week period with the goal of achieving 10% weight loss within this time. Weekly serum leptin measurements were performed to determine whether changes in this adipose protein would serve as a useful marker ...

journal_title：Journal of endocrinological investigation

authors： Xenachis C,Samojlik E,Raghuwanshi MP,Kirschner MA

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...

journal_title：Journal of endocrinological investigation

authors： Akbaş S,Karabekiroğlu K,Ozgen T,Tasdemir G,Karakurt M,Senses A,Böke O,Aydin M

更新日期：2009-04-01 00:00:00

abstract：:Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...

journal_title：Journal of endocrinological investigation

authors： New MI,Gertner JM,Speiser PW,Del Balzo P

更新日期：1989-01-01 00:00:00

abstract：:Endothelins (ETs) are potent vasoconstrictive peptides released from the endothelium and other tissues, which act on target cells by receptorial calcium-mediated mechanisms. ET-1 levels are increased in diabetes, and observations suggest the involvement of ETs in the pathogenesis of diabetic angiopathy. However, it is...

journal_title：Journal of endocrinological investigation

authors： De Carlo E,Milanesi A,Martini C,Maffei P,Sicolo N,Scandellari C

更新日期：2000-04-01 00:00:00

abstract：:Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...

journal_title：Journal of endocrinological investigation

authors： Ajlouni KM,Sliman NA,Najdawi A,Abu-Hajir MM,Arnaout MA

更新日期：1988-09-01 00:00:00

abstract：:Prolactin (PRL) circulates as multiple molecular weight variants: glycosylated phosphorylated, deamidated and sulphated forms. The profiles of the forms, as determined by isoelectrofocusing (IEF), differ in physiological and pathological conditions. The case of a 72-year-old woman affected by an invasive prolactinoma ...

journal_title：Journal of endocrinological investigation

authors： Guido R,Valenti S,Foppiani L,De Martini D,Cossu M,Giusti M

更新日期：1997-05-01 00:00:00

abstract：:Erectile dysfunction (ED) has been defined by the National Institute of Health (NIH) as the inability to achieve and/or to maintain an erection for a sufficiently long period of time so as to permit satisfactory sexual intercourse. ED affects millions of men throughout the world and could have a negative influence on ...

journal_title：Journal of endocrinological investigation

authors： Foresta C,Caretta N,Aversa A,Bettocchi C,Corona G,Mariani S,Rossato M

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor I (IGF-I) represents an essential tool in the diagnostic work-up and in the monitoring of treatment efficacy for somatotrophic axis disorders both in children and adults. A large number of factors including, but not limited to, age, sex and weight as well as analytical variables influ...

journal_title：Journal of endocrinological investigation

authors： Guitelman M,Smithuis F,Garcia Basavilbaso N,Aranda C,Fabre B,Oneto A

更新日期：2015-09-01 00:00:00

abstract：:We report a rare case of bilateral adrenocortical adenomas causing ACTH-independent Cushing's syndrome at different periods 9 yr apart. The subject, a 24-yr-old woman, in June 1989 had a typical Cushingoid appearance. Her baseline plasma cortisol levels did not show a diurnal rhythm and she had a very low baseline pla...

journal_title：Journal of endocrinological investigation

authors： Tung SC,Wang PW,Huang TL,Lee WC,Chen WJ

更新日期：2004-04-01 00:00:00

abstract：:We evaluated the usefulness of premarin priming on exercise induced growth hormone release and the value of combining several growth hormone screening agents in a large population of prepubertal children. Two hundred five short healthy prepubertal children growing below the 5th percentile in height were studied. One h...

journal_title：Journal of endocrinological investigation

authors： Lanes R,Lifshitz F,Sekaran C,Fort P,Recker B

更新日期：1986-12-01 00:00:00

abstract：:The multiple effects of vitamin D on skeletal and extra-skeletal tissues increased the attention of scientists and public to the possible relationship between hypovitaminosis D and a variety of acute and chronic diseases. However, several points are still largely debated. In particular, the definition of optimal vitam...

journal_title：Journal of endocrinological investigation

authors： Romagnoli E,Carnevale V,Biondi P,Minisola S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...

journal_title：Journal of endocrinological investigation

authors： Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:No data on the prevalence of erectile dysfunction (ED) in subjects with newly diagnosed Type 2 diabetes mellitus (T2DM) are currently available. AIM:The aim of the present study was to estimate the prevalence of ED and its associated causes in a sample of male patients with recently diagnosed DM (<24 mont...

journal_title：Journal of endocrinological investigation

authors： Corona G,Giorda CB,Cucinotta D,Guida P,Nada E,SUBITO-DE study group.

更新日期：2013-11-01 00:00:00

abstract：:Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. GC influence bone metabolism via a modulation of different components of the GH/IGF-I system. GH has multiple anabolic effects on bone, either direct or mediated by IGF-I. GH-deficient subjects have significant reduction in bo...

journal_title：Journal of endocrinological investigation

authors： Lombardi G,Colarusso S,Di Somma C,Guerra E,Tauchmanova L,Colao A

更新日期：2008-07-01 00:00:00

abstract：:We investigated ACTH and cortisol responses after ovine CRF injection (1 microgram/kg one bolus) in a group of 11 drug-free patients suffering from major depression. When compared to sex- and age-matched normal controls, our depressed patients showed: Higher ACTH basal values (p less than 0.002); higher cortisol basal...

journal_title：Journal of endocrinological investigation

authors： Nerozzi D,Bersani G,Melia E,Magnani A,Antonozzi I,Frajese G

更新日期：1988-11-01 00:00:00

abstract：:Cerebral ischemia and symptoms of stroke can occur as a rare manifestation in patients with pheochromocytoma. We describe a 45-year-old woman who was admitted because of a right-sided hemiparesis due to an ischemic lesion in the left hypothalamus. The clinical diagnosis of a pheochromocytoma was proven by highly eleva...

journal_title：Journal of endocrinological investigation

authors： Lehmann FS,Weiss P,Ritz R,Harder F,Staub JJ

更新日期：1999-03-01 00:00:00

abstract：:Unfortunately, the fourth author's middle name was missed out in the original publication of this article. The complete correct name should read as follows. ...

journal_title：Journal of endocrinological investigation

authors： Tresoldi AS,Sburlati LF,Rodari M,Schinkelshoek MS,Perrino M,De Leo S,Montefusco L,Colombo P,Arosio M,Lania AGA,Fugazzola L,Chiti A

更新日期：2018-08-01 00:00:00

abstract：:We report an original application of quantitative reverse transcription-polymerase chain reaction (Q.RT-PCR) for the evaluation of atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta-actin mRNA in small atrial samples (10-15 mg). A fixed amount of total RNA was simultaneously reverse transcribed ...

journal_title：Journal of endocrinological investigation

authors： Iascone MR,Vittorini S,Collavoli A,Cupelli A,Kraft G,Biagini A,Clerico A

更新日期：1999-12-01 00:00:00

abstract：:Evaluation of thyroid status by measurement of free thyroid hormone concentrations seems particularly helpful in conditions with altered serum binding proteins. In pregnancy, a condition of increased thyroxine binding globulin, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations have been reporte...

journal_title：Journal of endocrinological investigation

authors： Roti E,Gardini E,Minelli R,Bianconi L,Flisi M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Elevated γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) could predict the risk of Type 2 diabetes (T2D), but the reason for their elevation was unclear. GGT and ALT mediated the metabolism of many amino acids (AA). Up to now, it was not investigated whether abnormal AA concentration was a...

journal_title：Journal of endocrinological investigation

authors： Chen T,Zhang X,Long Y,Yu H,Ran X,Gao Y,Lu H,Xie X,Chen X,Ren Y,Shi J,Tian H

更新日期：2012-09-01 00:00:00

abstract：:17alpha-hydroxylase deficiency (17alpha-OHDS) results in decreased production of cortisol and sex steroids and hypokalemia secondary to excess mineralocorticoids. It has long been known that glucocorticoid deficiency is associated with impaired urinary dilution and increased secretion of vasopressin (AVP). On the othe...

journal_title：Journal of endocrinological investigation

authors： Leal AM,Elias PC,Moreira AC

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A>G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated se...

journal_title：Journal of endocrinological investigation

authors： Labruna G,Pasanisi F,Nardelli C,Tarantino G,Vitale DF,Bracale R,Finelli C,Genua MP,Contaldo F,Sacchetti L

更新日期：2009-06-01 00:00:00

abstract：:Data concerning the cardiovascular manifestations of primary hyperparathyroidism (PHPT) are inconsistent, which is due, in part, to the decrease in disease severity over the last several decades. In areas where patients tend to be more symptomatic, data support the presence of cardiovascular findings including myocard...

journal_title：Journal of endocrinological investigation

authors： Walker MD,Silverberg SJ

更新日期：2008-10-01 00:00:00

abstract：:Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper under...

journal_title：Journal of endocrinological investigation

authors： Pendin D,Greotti E,Filadi R,Pozzan T

更新日期：2015-01-01 00:00:00

abstract：:We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma excha...

journal_title：Journal of endocrinological investigation

authors： Atabay C,Schrooyen M,Zhang ZG,Salvi M,Glinoer D,Wall JR

更新日期：1993-10-01 00:00:00

abstract：:Anatomy studies normally precede physiology. While the anatomy of the penis and the biochemical and molecular regulation of erection are largely known, the exact anatomical description of the human clitoris was produced in 1998, the taxonomy of female sexual dysfunctions classified in 1999, and biochemistry of female ...

journal_title：Journal of endocrinological investigation

authors： D'Amati G,di Gioia CR,Proietti Pannunzi L,Pistilli D,Carosa E,Lenzi A,Jannini EA

更新日期：2003-01-01 00:00:00

abstract：:The present experiments were undertaken to study the effect of complete food removal on body weight, pituitary growth hormone (GH), plasma GH and glucose concentration in male and female Wistar rats. Plasma and pituitary GH levels were measured by means of a specific radioimmunoassay. Plasma glucose concentration decr...

journal_title：Journal of endocrinological investigation

authors： Gonzalez C,Jolin T

更新日期：1981-01-01 00:00:00

abstract：AIM:This 3-month study compared the effect on overall glycemic control of adding biphasic insulin aspart 30 (BIAsp30) and premixed human insulin 30/70 (BHI30) to metformin (met) in insulin-naïve, obese patients (30 males/20 females) with Type 2 diabetes (T2DM). MATERIAL/SUBJECTS: At baseline, patients had a mean age of...

journal_title：Journal of endocrinological investigation

authors： Velojic-Golubovic M,Mikic D,Pesic M,Dimic D,Radenkovic S,Antic S

更新日期：2009-01-01 00:00:00