Abstract：
PURPOSE:Cold exposure activates the hypothalamus-pituitary-thyroid (HPT) axis, response blunted by previous acute stress or corticosterone administration. Chronic stressors can decrease serum T3 concentration, and thyrotropin-releasing hormone (Trh) expression in the paraventricular nucleus (PVN), but impact on the response to cold is unknown; this was studied in rats submitted to daily repeated restraint (rRes) that causes habituation of hypothalamus-pituitary-adrenal (HPA) axis response, or to chronic variable stress (CVS) that causes sensitization and hyperreactivity. METHODS:Wistar male adult rats were submitted to rRes 30 min/day, or to CVS twice a day, for 15 days. On day 16, rats were exposed 1 h to either 5 or 21 °C. Parameters of HPT and HPA axes activity and of brown adipose tissue (BAT) cold response were measured; gene expression in PVN and BAT, by RT-PCR; serum hormone concentration by radioimmunoassay or ELISA. RESULTS:Compared to naïve animals, Crh and corticosterone concentrations were attenuated at the end of rRes, but increased at the end of CVS treatments. Cold exposure increased mRNA levels of Crh, Trh, and serum concentration of thyrotropin in naïve, but not in rRes or CVS rats; corticosterone increased in all groups. Cold induced expression of thermogenic genes in BAT (Dio2 and Ucp1) in naïve but not in stressed rats; Adrb3 expression was differentially regulated. CONCLUSION:Both types of chronic stress blunted HPT and BAT responses to cold. Long-term stress effects on noradrenergic and/or hormonal signaling are likely responsible for HPT dysfunction and not the type of chronic stressor.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Castillo-Campos A,Gutiérrez-Mata A,Charli JL,Joseph-Bravo Pdoi
10.1007/s40618-020-01328-zsubject
Has Abstractpub_date
2020-07-30 00:00:00eissn
0391-4097issn
1720-8386pii
10.1007/s40618-020-01328-zpub_type
杂志文章abstract：:The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:In 1992 a significant relationship between bone turnover and the vitamin D receptor (VDR) genotype was reported in Australian subjects of UK-Irish decent. Since then, several groups have investigated the relationship between VDR and other bone-related genotypes, bone mass and bone turnover in several populations. Howe...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03343853
更新日期：2001-04-01 00:00:00
abstract：:The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility. However, other genes have been recently mapped to this region and they could contribute to the AZFc phenotype. In particular, the testis-specific CDY1 (chromadomain protein 1) ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343814
更新日期：2001-02-01 00:00:00
abstract：:The adrenomedullary response to stimuli is often elevated in poorly controlled insulin dependent diabetic patients, and it is controversial whether the adrenomedullary hyperactivity induces the suppression of the circadian rhythm of catecholamines. We have studied the urinary excretion of catecholamines in 11 diabetic...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348628
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND/AIMS:Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular ris...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346627
更新日期：2010-07-01 00:00:00
abstract：:The aim of our study was to investigate the effects of estradiol (E2) and/or progesterone (P4) bilateral ovariectomized rats on gene expressions of adenylyl cyclases (AC2, AC4, AC6, AC9). Non-pregnant (NP) Wister rats (between post-natal 10 and 12 weeks) and normal pregnant rats (between postnatal 10 and 14 weeks) wer...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347203
更新日期：2005-04-01 00:00:00
abstract：:Endothelins (ETs) are potent vasoconstrictive peptides released from the endothelium and other tissues, which act on target cells by receptorial calcium-mediated mechanisms. ET-1 levels are increased in diabetes, and observations suggest the involvement of ETs in the pathogenesis of diabetic angiopathy. However, it is...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343715
更新日期：2000-04-01 00:00:00
abstract：:The aim of the study was to examine the effects of strenuous training on the hypothalamic- pituitary-adrenal axis activity. Exercise tests and saliva collections for analysis of awakening cortisol response (ACR) and midnight cortisol were performed before and after a 7-day period of intensified training in a group of ...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03345561
更新日期：2008-01-01 00:00:00
abstract：:The case of a 34-yr-old Caucasian male with Graves' disease presenting with a flaccid quadriplegia and severe hypokalemia is reported. The weakness was prevalent at the lower extremities and began during nocturnal sleep, after a strenuous physical exertion performed during the day. Correction of hypokalemia promptly r...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347807
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:Two yr after legislation of salt iodization of 40 parts per million (ppm) in 1994, goiter was still endemic and urinary iodine concentration (UIC) remained elevated in many provinces of Iran. Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian ho...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346386
更新日期：2008-05-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347639
更新日期：1992-11-01 00:00:00
abstract：:A possible participation of central serotoninergic or noradrenergic neurons on nyctohemeral periodicity of plasma TSH concentration was studied in the rat. Control rats exhibited normal nyctohemeral fluctuations of plasma TSH characterized by high AM (09:30) and low PM (18:30) values (397 +/- 45 vs. 207 +/- 28 ng/ml, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348270
更新日期：1980-07-01 00:00:00
abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0946-5
更新日期：2018-12-01 00:00:00
abstract：:Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and agi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.3275/7926
更新日期：2011-11-01 00:00:00
abstract：:The present study was performed in 30 patients who needed steroid therapy: courses of triamcinolone or DTM 8-15 given orally lasted 30 days. In 15 of these patients glucoactive corticosteroids were administered in combination with 5 micrograms/day of 25OH-vitamin D3 (25OHD3). 47Calcium oral test and 99mTc-MDP kinetics...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348448
更新日期：1984-10-01 00:00:00
abstract：:We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadeno...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03351046
更新日期：2001-06-01 00:00:00
abstract：:Data concerning the cardiovascular manifestations of primary hyperparathyroidism (PHPT) are inconsistent, which is due, in part, to the decrease in disease severity over the last several decades. In areas where patients tend to be more symptomatic, data support the presence of cardiovascular findings including myocard...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03346443
更新日期：2008-10-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349691
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:The aim of the study was to evaluate diurnal blood pressure (BP) profiles in patients with primary aldosteronism and to compare them to those in subjects with essential hypertension. The effects of specific therapy on the circadian BP profiles have been studied. MATERIALS AND METHODS:Sixty-four patients wit...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349173
更新日期：2006-01-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346520
更新日期：2009-07-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type：
doi：
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:Although a nation-wide salt iodization program on voluntary basis was implemented in 2005, many areas in our country are still characterized by mild iodine deficiency. Differently from the rest of Italy, an efficient program of iodine prophylaxis was implemented in 1981 in the Autonomous Province of Bolzano. Th...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0206-2
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,多中心研究
doi：10.1007/s40618-016-0604-8
更新日期：2017-06-01 00:00:00
abstract：:Aromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase activity tended to be high in the proliferative cells compared to the secretory...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349962
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:Graves' orbitopathy (GO) is an inflammatory orbital disease of autoimmune origin with the potential to cause severe functional and psychosocial effects. The pathogenesis has not been fully elucidated. We investigated whether DNA methylation was associated with GO incidence in Chinese patients. MATERIALS AND ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0796-6
更新日期：2018-06-01 00:00:00
abstract：:Human thyroid blood flow rate (TBF) was measured during operations by electromagnetic flowmetry in 75 euthyroid patients with normal thyroid tissue, nodular goiter, or solitary adenoma, and in 22 hyperthyroid patients with diffuse or nodular goiter. Blood flow rate was measured in one to four of the thyroid arteries. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349454
更新日期：1981-07-01 00:00:00
abstract：:The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-017-0732-9
更新日期：2018-01-01 00:00:00
abstract：:The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348582
更新日期：1990-01-01 00:00:00
abstract：:Up to now, the diagnosis of silent corticotroph cell pituitary adenomas has been made only on histopathological basis. In this paper we describe 6 women affected with pituitary adenomas, without evident clinical features of hypercortisolism, in whom retrospective data suggested the possibility of clinically diagnosing...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348769
更新日期：1992-06-01 00:00:00
abstract：:Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with rena...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2011-07-01 00:00:00
