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Feminization as a result of both peripheral conversion of androgens and direct estrogen production from an adrenocortical carcinoma.

Abstract：

:A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary 17-ketosteroid and free cortisol excretion. Removal of a 10 kg adrenocortical carcinoma led to normalization of the hormone concentrations and partial resolution of the gynecomastia. There was no clinical evidence of metastases. Incubation of tumor slices demonstrated that the tumor had an active aromatase and sulfotransferase. We estimated that about half the serum estrone arose from peripheral conversion of androstenedione. Feminizing adrenocortical carcinomas are rare and this case is unusual given the lack of clinical metastases and the probable dual source of estrogen from tumor as well as from the peripheral conversion of tumor-derived androgens.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Zayed A,Stock JL,Liepman MK,Wollin M,Longcope C

doi

10.1007/BF03348975

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

275-8

issue

4

eissn

0391-4097

issn

1720-8386

journal_volume

17

pub_type

杂志文章

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