Abstract:
:Fifty seven male patients either complaining of poor sexual development, gynecomastia or dwarfism and signs of sexual infantilism were studied. Plasma prolactin (PRL) and testosterone (T) were estimated in all patients while 33 of them were also subjected to full pituitary function tests. Twelve of the latter had an elevated basal plasma cortisol or growth hormone which suggested the patient may have been "stressed"; the results were analyzed both excluding and including these patients. The remaining patients were divided into those with a plasma T less than 8.0 nmol/l (Group A, 25 patients) and those with a plasma T greater than 8.0 nmol/l (Group B, 20 patients). The results were compared with those from 18 normal men (Group C). The mean plasma PRL in group A (108.1 mU/l) was significantly lower than that in group B (181.5 mU/l, p less than 0.005) or group C (255.7 mU/l, p less than 0.001). The difference between groups A and B became much less (p less than 0.01) when results from the "stressed" patients were included but this did not affect the difference with group C. The mean plasma PRL in group B was also significantly lower (p less than 0.05) than that in group C but the significance of the difference disappeared when all the patients were included (p less than 0.2). In the patients there was a significant correlation between plasma and PRL plasma T (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Hipkin LJ,Diver MJ,Davis JCdoi
10.1007/BF03346965subject
Has Abstractpub_date
1986-12-01 00:00:00pages
453-7issue
6eissn
0391-4097issn
1720-8386journal_volume
9pub_type
杂志文章abstract::The occurrence of tumors originating from aberrant adrenocortical tissue in ectopic site is very rare. Up to now only two cases of ectopic aldosterone-producing adenoma have been described. We have observed another case of ectopic aldosteronoma, located in the retrocaval region, laterally to the body of the 12th thora...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349816
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-020-01441-z
更新日期:2020-10-09 00:00:00
abstract:PURPOSE:In our previous study, we introduced a rat model of polycystic ovary syndrome (PCOS) induced by prenatal exposure to a single dose of testosterone on embryonic day 20. In the current study, we aimed to investigate whether prenatal exposure to a single dose of testosterone could also induce metabolic disturbance...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0198-y
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis. METHODS:We retrospectivel...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01100-y
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Testosterone replacement therapy (TRT) is recommended for the treatment of most cases of male hypogonadism. Transdermal testosterone (T) gels are commonly used in clinical practice; however, there is little evidence concerning how to monitor dosage to bring and maintain serum T levels in the normal physiologic ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01082-x
更新日期:2019-12-01 00:00:00
abstract::We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the up...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347433
更新日期:2007-03-01 00:00:00
abstract::The syndrome of apparent mineralocorticoid syndrome (AME) results from defective 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol to its inactive metabolite cortisone. Its deficiency allows the unmetabolized co...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343755
更新日期:2000-07-01 00:00:00
abstract::In a 12-yr-old boy growth arrest occurred after severe head trauma. Evaluation of pituitary endocrine function revealed isolated growth hormone (GH) deficiency. Lack of GH response to GH-releasing factor indicated that the responsible lesion was most likely to be localized in the pituitary gland. GH substitution resul...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349069
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:In contrast with maximal voluntary resistance exercise, which is allegedly considered a potent GH stimulus in young subjects, evaluation of GH response to whole-body vibrations (WBV) has yielded conflicting results. METHODS:The acute effects of WBV alone (test A), maximal voluntary isometric contractions (M...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347069
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345623
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
doi:10.3275/7749
更新日期:2012-01-01 00:00:00
abstract:AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347461
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Depressive disorder encompasses a wide spectrum of somatic and psychological symptoms. It is not known whether there are differences regarding the cluster of depressive symptomatology between subjects with depression with and without T2DM. PURPOSE:To explore whether the cluster of depression that prevails a...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01020-x
更新日期:2019-08-01 00:00:00
abstract::Circadian rhythms of hormone secretion are by now well recognized but there are limited data available to compare such rhythms of multiple hormones in individual subjects. Therefore concentrations of serum thyrotropin (TSH), cortisol, growth hormone (GH), triiodothyronine (T3) and prolactin (PRL) were determined in bl...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349346
更新日期:1979-10-01 00:00:00
abstract::We have measured eye muscle antibodies, in immunoblotting, in the serum from five patients with severe ophthalmopathy associated with Graves' hyperthyroidism who underwent plasmapheresis, correlating their levels with clinical features of the eye disorder and response to treatment. Blood taken before each plasma excha...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348906
更新日期:1993-10-01 00:00:00
abstract::The changes occurring in the levels of circulating thyroid microsomal antibody (M-Ab) and antithyroglobulin antibody (Tg-Ab) during antithyroid drug therapy were studied in 32 patients receiving methimazole for Graves' disease. M-Ab was determined by competitive binding radioassay and Tg-Ab by a sandwich radiometric m...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350476
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8369
更新日期:2012-11-01 00:00:00
abstract::Pathogenesis of idiopathic diabetes insipidus is unknown and the clinical course of the disease is permanent. However, we observed one patient who was diagnosed of idiopathic diabetes insipidus spontaneously reverted after approximately 13 months. The cause and pathogenesis of the disease were not evident. However, so...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350038
更新日期:1989-11-01 00:00:00
abstract::Experimental data concerning the role of serotonin (5-HT) in the control of gonadotropins secretion remain controversial: different receptors subtypes should mediate the serotoninergic action. In the present work we analyzed in prepubertal and adult male rats the FSH and LH responses after administration of the follow...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347993
更新日期:1997-07-01 00:00:00
abstract::During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348450
更新日期:1984-10-01 00:00:00
abstract::We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po)....
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF03347908
更新日期:1991-10-01 00:00:00
abstract::Although TRIAC is bound at least twice as avidly to nuclear receptor as T3, its thyromimetic potency is relatively low and its effect at the pituitary level on thyrotropin (TSH) secretion seems to be dissociated from that at the peripheral tissue level. In order to gain further insight into the complex effects of this...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350116
更新日期:1988-02-01 00:00:00
abstract::Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349195
更新日期:2006-11-01 00:00:00
abstract::In normal man 1,25 (OH)2-vitamin D3 [1,25 (OH)2D] increases both basal and TRH-stimulated prolactinemia; this effect is completely reversible by the calcium antagonist nifedipine. Similarly the 1,25 (OH)2D-induced hypercalcemia is totally inhibited by nifedipine. These findings suggest that both biological effects of ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350657
更新日期:1985-04-01 00:00:00
abstract::Multiple pituitary hormone hypersecretions have already been described, but the co-occurrence of PRL and ACTH excess is very rare. To our knowledge, medical treatment with cabergoline only, avoiding pituitary surgery and radiotherapy in this type of tumor has never been reported before. This case report deals with a 3...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343983
更新日期:2002-02-01 00:00:00
abstract::A possible participation of central serotoninergic or noradrenergic neurons on nyctohemeral periodicity of plasma TSH concentration was studied in the rat. Control rats exhibited normal nyctohemeral fluctuations of plasma TSH characterized by high AM (09:30) and low PM (18:30) values (397 +/- 45 vs. 207 +/- 28 ng/ml, ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348270
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:Metastases to the thyroid gland are uncommon and they represent 1-3% of all thyroid malignancy. The aim of this study is to analyze the diagnostic problems and the role of surgery in metastatic lesions to the thyroid. METHODS:We retrospectively analyzed all patients who had undergone thyroidectomy at our Cente...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-020-01282-w
更新日期:2020-11-01 00:00:00
abstract::Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)7 allele on the peak bone mass attainment in males was studied. Fifty-eight unrelat...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346329
更新日期:2007-06-01 00:00:00
abstract::We report the case of a patient who developed Graves' disease and a papillary thyroid cancer only 5 years after irradiation and adjuvant chemotherapy for Hodgkin's disease. This case is peculiar for the very short latency time between Hodgkin's disease treatment and thyroid cancer development, an event possibly relate...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349835
更新日期:1995-12-01 00:00:00
abstract::Exhaustive graded exercise leads to changes of hormones, carbohydrate, and lipid metabolism in normal controls and obese patients after prolonged starvation. Concomitant with a large increase of plasma catecholamines, insulin concentration is reduced and blood glucose levels slowly increase. More glucose is made avail...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348344
更新日期:1983-12-01 00:00:00