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Prolactin response to growth hormone-releasing hormone during chronic thyrotropin-releasing hormone infusion in the treatment of amyotrophic lateral sclerosis.

Abstract：

:In six patients suffering from amyotrophic lateral sclerosis we evaluated changes of T4, T3, TSH, PRL, and GH during treatment by continuous iv infusion of TRH for at least 15 days. No clinical improvement was detected. A significant rise of thyroid hormone levels was observed, as well as an upward trend of basal TSH levels and no change of basal PRL and GH levels. TRH acute test-induced TSH and PRL responses became blunted. Treatment provoked also the onset of a responsiveness of PRL to GHRH. The reduced TSH and PRL responses to acute TRH test during treatment could be explained by a down-regulation of TRH pituitary receptors. On the contrary, the onset of PRL responsiveness to GHRH is at present without a satisfactory explanation.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Chiodini PG,Attanasio R,Liuzzi A,Cozzi R,Orlandi P,De Palo C,Dallabonzana D,Girotti F,Testa D

doi

10.1007/BF03349584

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

631-6

issue

8

eissn

0391-4097

issn

1720-8386

journal_volume

13

pub_type

杂志文章

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