Epigenetics: spotlight on type 2 diabetes and obesity.

Abstract:

:Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.

journal_name

J Endocrinol Invest

authors

Desiderio A,Spinelli R,Ciccarelli M,Nigro C,Miele C,Beguinot F,Raciti GA

doi

10.1007/s40618-016-0473-1

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

1095-103

issue

10

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-016-0473-1

journal_volume

39

pub_type

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