Abstract:
:The coexistence of hyperparathyroidism complicating thyrotoxicosis is quite rare. We report the case of one patient who presented with thyrotoxicosis, (total thyroxine of 15.1 micrograms/dl (5-13), free thyroxine index of 18 (4-15) and triiodothyronine by RIA of 305 ng/dl (70-230) and asymptomatic hypercalcemia of 15 mg/dl (8.5-10.6), who was also initially noted to have an elevated (C-terminal) serum immunoreactive parathyroid hormone (iPTH) level of 8,800 pg/ml (50-340). With propylthiouracil and propranolol, however, this patient became normocalcemic with a decrease in iPTH values to 714 pg/ml. As the patient was tapered from medication, after being rendered euthyroid, a recurrence of hypercalcemia with rising iPTH levels occurred. PTH levels should be helpful in defining coexisting hyperparathyroidism in patients with thyrotoxicosis since in the latter iPTH is usually suppressed. Our findings support the recommendation that in patients suspected of having both hyperparathyroidism and hyperthyroidism, a diagnosis of the former can only be made with certainty after the patient has been rendered euthyroid with persistently elevated serum calcium and iPTH levels. While there are no clinical features which permit the easy identification of patients who present with dual lesions, the determination of iPTH values may be the most consistently helpful test initially, whereas other parameters such as vitamin D, serum phosphate are less reliable.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
McGowan DM,Vaswani A,Shperling Idoi
10.1007/BF03346819subject
Has Abstractpub_date
1991-04-01 00:00:00pages
305-10issue
4eissn
0391-4097issn
1720-8386journal_volume
14pub_type
杂志文章,评审abstract:AIMS:To investigate the prevalence of metabolic syndrome and its components in both rural and urban Chinese population. SUBJECTS AND METHODS:A population-based crosssectional survey was conducted in Qingdao, China in 2006 with 6100 Chinese aged 35-74 yr invited and 5355 who attended; 3357 subjects, 1562 urban (46.5%) ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
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更新日期:2011-06-01 00:00:00
abstract::Up to now, the diagnosis of silent corticotroph cell pituitary adenomas has been made only on histopathological basis. In this paper we describe 6 women affected with pituitary adenomas, without evident clinical features of hypercortisolism, in whom retrospective data suggested the possibility of clinically diagnosing...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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abstract::The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
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更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a successful treatment for progressive secondary hyperparathyroidism (SHPT) patients subjected to surgery,...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-015-0410-8
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abstract::The TSH responses to the catecholamine depleting agent monoiodotyrosine (1 g po) and the dopamine receptor blocking drug metoclopramide (10 mg po) have been compared in euthyroid and hypothyroid subjects. Both drugs lead to a prompt and significant rise in TSH levels (peak values at 60-75 min) which is very much great...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348238
更新日期:1980-04-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1982-05-01 00:00:00
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更新日期:2001-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349069
更新日期:1988-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345471
更新日期:1999-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-016-0441-9
更新日期:2016-06-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349031
更新日期:1996-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349633
更新日期:1990-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03345683
更新日期:2009-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349891
更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347856
更新日期:1996-01-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-10-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-014-0191-5
更新日期:2014-11-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347807
更新日期:1995-03-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
abstract::There is increasing evidence that androgen therapy in men may be effectively applied in several conditions to improve well being and health. Classical indications for androgen therapy in males are represented by primary or secondary hypogonadism, delayed puberty, aplastic anemia and that secondary to chronic renal fai...
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pub_type: 杂志文章,评审
doi:10.1007/BF03343707
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00