Growth hormone and insulin-like growth factor-1 in blood and urine as response markers during treatment of acromegaly with octreotide: a double-blind placebo-controlled study.

abstract：:In a 12-yr-old boy growth arrest occurred after severe head trauma. Evaluation of pituitary endocrine function revealed isolated growth hormone (GH) deficiency. Lack of GH response to GH-releasing factor indicated that the responsible lesion was most likely to be localized in the pituitary gland. GH substitution resul...

journal_title：Journal of endocrinological investigation

authors： Eichler I,Frisch H,Eichler HG,Soukop W

更新日期：1988-06-01 00:00:00

abstract：:The role of androgens in human sexuality as regards the mechanism of erection and the pathogenesis of impotence is under debate. In addition, it is difficult to define the psychosocial impact of both hypogonadism and androgen replacement. However, sexual hormones largely influence mood, well-being, and quality of life...

journal_title：Journal of endocrinological investigation

authors： Carosa E,Volpe R,Martini P,Brandetti F,Di Stasi SM,Lombardo F,Salacone P,Sgrò P,Gandini L,Lenzi A,Jannini EA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The Middle East registers the highest rate of vitamin D deficiency worldwide. In Lebanon, previous studies looked at this deficiency in schoolchildren, university students, young adults and postmenopausal women. However, no previous study was performed in hospital workers. The objective of our study was to e...

journal_title：Journal of endocrinological investigation

authors： Gannagé-Yared MH,Helou E,Zaraket V,Abi Akl S,Antonios L,Moussalli ML,Wakim S

更新日期：2014-06-01 00:00:00

abstract：:The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...

journal_title：Journal of endocrinological investigation

authors： Fonzo D,Germano L,Gallone G,Migliardi M

更新日期：2003-12-01 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced inflammatory stress activates the hypothalamus-pituitary-adrenal (HPA) function. Interleukin-I (IL-1) is one of the key factors during this event; however, the mechanisms mediating IL-1 stimulation of HPA axis are still unclear. The present study evaluated the possible involvement of g...

journal_title：Journal of endocrinological investigation

authors： Guo AL,Petraglia F,Nappi RE,Criscuolo M,Ficarra G,Salvestroni C,Genazzani AD,Trentini GP,Genazzani AR

更新日期：1996-02-01 00:00:00

abstract：:There is increasing evidence that androgen therapy in men may be effectively applied in several conditions to improve well being and health. Classical indications for androgen therapy in males are represented by primary or secondary hypogonadism, delayed puberty, aplastic anemia and that secondary to chronic renal fai...

journal_title：Journal of endocrinological investigation

authors： Gambineri A,Pasquali R

更新日期：2000-03-01 00:00:00

abstract：:Not only thyroid adenomas and carcinomas, but also the majority of single and well delimited goiter nodules, even if morphologically heterogeneous, are of clonal origin. However, it is still unknown whether the nodules of rapidly growing, recurrent goiters are clonal or polyclonal. We investigated by PCR-based analysi...

journal_title：Journal of endocrinological investigation

authors： Harrer P,Broecker M,Zint A,Schatz H,Zumtobel V,Derwahl M

更新日期：1998-06-01 00:00:00

abstract：:A technique has been developed with which it has been possible to quantify the output of a wide variety of agonists including catecholamines, glucocorticoids, mineralocorticoids, enkephalins and various peptides, from the adrenal gland in the conscious unrestrained calf; also to investigate responses to electrical sti...

journal_title：Journal of endocrinological investigation

authors： Edwards AV,Ghatei MA,Bloom SR

更新日期：1990-12-01 00:00:00

abstract：:Thyroid diseases may lead to endothelial dysfunction; however, the mechanism underlying the endothelial dysfunction in thyroid disease is not clear yet. Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine. Symmetric dimet...

journal_title：Journal of endocrinological investigation

authors： Arikan E,Karadag CH,Guldiken S

更新日期：2007-03-01 00:00:00

abstract：:N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular Ca2+, with ensuing activation of a variety of Ca(2+)-dependent enzymes, including protein kinase C. This triggers...

journal_title：Journal of endocrinological investigation

authors： Caruso S,Agnello C,Campo MG,Nicoletti F

更新日期：1993-12-01 00:00:00

abstract：:The effects of short term administration of 200 MRC U of synthetic salmon calcitonin (sCT) daily on carbohydrate metabolism were investigated in 10 patients with various bone diseases, 3 of whom had type II diabetes mellitus and 3 of whom had impaired glucose tolerance. Blood glucose levels during the nocturnal postab...

journal_title：Journal of endocrinological investigation

authors： Giustina G,Cerudelli B,Cimino A,Rigosa C,Rotondi A,Radaeli E

更新日期：1985-02-01 00:00:00

abstract：:Pegvisomant, a GH receptor antagonist, is a new pharmaceutical approach to acromegaly. It enables IGF-I levels to return in the age- and sex-reference range in approximately 90% of patients. This new approach is particularly beneficial in those patients who do not experience control of hormone hypersecretion after sur...

journal_title：Journal of endocrinological investigation

authors： Colao A,Pivonello R,Cappabianca P,Auriemma RS,De Martino MC,Ciccarelli A,de Divitiis E,Lombardi G

更新日期：2003-01-01 00:00:00

abstract：:We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, concentrations of LH, FSH, TSH, growth hormone and prolactin were measured in blood collected at 10-min interval...

journal_title：Journal of endocrinological investigation

authors： Davis M,Nassberg B,Borges JL,Iranmanesh A,Lizzaralde G,Santen RJ,Drake C,Rogol AD,Kaiser DL,Thorner MO

更新日期：1987-10-01 00:00:00

abstract：:Erythrocytes glutathione (GSH) levels were measured in erythrocytes from 33 subjects, at baseline and after 2-hour glucose loading in order to investigate the effect of glucose ingestion on the erythrocyte GSH. According to the World Health Organisation criteria 18 subjects had normal glucose tolerance (NGT)(mean age ...

journal_title：Journal of endocrinological investigation

authors： Konukoğlu D,Hatemi H,Ozer EM,Gönen S,Akçay T

更新日期：1997-09-01 00:00:00

abstract：:Recently, bromocriptine has been successfully introduced as medical therapy for the pituitary hypersecreting syndromes of hyperprolactinemia and acromegaly. Subsequently, an inhibitory effect on ACTH secretion was reported using bromocriptine in Cushing's disease. While most studies have focused on the acute response ...

journal_title：Journal of endocrinological investigation

authors： Kapcala LP,Jackson IM

更新日期：1982-03-01 00:00:00

abstract：:This is a brief case report on a four-month-old girl who was admitted for failure to thrive and moderate dehydration. On admission she was mildly dehydrated and undernourished but with otherwise normal physical findings. Laboratory investigation disclosed mild but constant hyponatremia and hyperkalemia, very high plas...

journal_title：Journal of endocrinological investigation

authors： Mardesić D,Sarnavka V,Dumić M,Stipić V

更新日期：1992-03-01 00:00:00

abstract：:The Nb2 rat lymphoma bioassay (BA) for prolactin (PRL) was performed in 26 subjects with hyperprolactinemia, 17 of whom had radiologic evidence of a pituitary adenoma. All subjects were treated with the long acting dopamine agonist CV 205-502. The radioimmunoassay (RIA) PRL significantly decreased with treatment but t...

journal_title：Journal of endocrinological investigation

authors： Peabody CA,Schultz PN,Warner MD,Worsley IG,Friesen HG,Samaan NA

更新日期：1992-07-01 00:00:00

abstract：:There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

journal_title：Journal of endocrinological investigation

authors： Warren MP,Goodman LR

更新日期：2003-09-01 00:00:00

abstract：AIM:Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are ...

journal_title：Journal of endocrinological investigation

authors： Bo S,Gambino R,Durazzo M,Ghione F,Musso G,Gentile L,Cassader M,Cavallo-Perin P,Pagano G

更新日期：2008-06-01 00:00:00

abstract：:Human GH (hGH) is a heterogeneous protein hormone consisting of several isoforms. This heterogeneity is the consequence of multiple hGH genes, mRNA splicing, post-translational modifications, and peripheral metabolism, and it represents one important reason for the disparity among GH assay results from different labor...

journal_title：Journal of endocrinological investigation

authors： Rigamonti AE,Bozzola M,Banfi G,Meazza C,Müller EE,Cella SG

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Primary hyperparathyroidism has deleterious effects on health and causes nephrolithiasis and osteoporosis. However, it remains unclear whether parathyroidectomy benefits kidney function among patients with primary hyperparathyroidism. METHODS:In this retrospective study, patients with primary hyperparathyroidi...

journal_title：Journal of endocrinological investigation

authors： Liang CC,Yeh HC,Lo YC,Chou CY,Yen TH,Tsai HC,Hsu SP,Kuo CC

更新日期：2020-07-29 00:00:00

abstract：:The effects of estriol on serum prolactin (PRL) and LH levels, on the pituitary response to TRH and LHRH and on the synthesis and release of PRL from the anterior pituitary gland were investigated in female rats. The increase of serum PRL levels after estradiol administration was found to be associated with an increas...

journal_title：Journal of endocrinological investigation

authors： Diaz MC,Seilicovich A,Duvilanski BH,Siseles N,Lasaga M,Debeljuk L

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The diagnosis of polycystic ovary syndrome (PCOS) is based on a combination of various clinical phenotypes in each patient. However, insulin resistance (IR) and dysmetabolism are not included in the diagnostic criteria of PCOS. Therefore, the definition of PCOS is controversial. The objective of this study is t...

journal_title：Journal of endocrinological investigation

authors： Zhang L,Fang X,Li L,Liu R,Zhang C,Liu H,Tan M,Yang G

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Hashimoto's thyroiditis (HT) is often associated with rheumatic disorders (arthritis, etc.), but many HT patients report non-specific rheumatic signs and symptoms in the absence of clinically evident rheumatic diseases. Aim of this study was to evaluate the prevalence of non-specific rheumatic manifestations (R...

journal_title：Journal of endocrinological investigation

authors： Giuffrida G,Bagnato G,Campennì A,Giovinazzo S,Keller KP,Alibrandi A,Roberts WN,Trimarchi F,Ruggeri RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a successful treatment for progressive secondary hyperparathyroidism (SHPT) patients subjected to surgery,...

journal_title：Journal of endocrinological investigation

authors： Xu D,Yin Y,Hou L,Dai W

更新日期：2016-05-01 00:00:00

abstract：:Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Agosti F,Proietti M,Adorni F,Sartorio A

更新日期：2006-11-01 00:00:00

abstract：:The status of the erythrocyte insulin receptor was investigated prior to and during storage at 4C in acid-citrate dextrose (ACD) solution. The receptors on cells that were obtained from both resting and exercised fasting subjects and stored for up to three days in ACD were unchanged as evaluated by both maximal specif...

journal_title：Journal of endocrinological investigation

authors： Robbins PA,Kwan C,Searle GL

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function. AIM:The aim of this study was to evaluate the effect of medical treatment with the GH receptor antagonist pegvisomant on vascular structure and function in ...

journal_title：Journal of endocrinological investigation

authors： De Martino MC,Auriemma RS,Brevetti G,Vitale G,Schiano V,Galdiero M,Grasso L,Lombardi G,Colao A,Pivonello R

更新日期：2010-10-01 00:00:00

abstract：:Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, ...

journal_title：Journal of endocrinological investigation

authors： Bagnasco M,Orlandini A,Melioli G,Venuti D,Canonica GW,Ferrara GB

更新日期：1987-04-01 00:00:00

abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...

journal_title：Journal of endocrinological investigation

authors： Hurst BS,Zacur HA,Schlaff WD,Berkovitz GD

更新日期：1992-09-01 00:00:00