Abstract：
:There is increasing evidence that androgen therapy in men may be effectively applied in several conditions to improve well being and health. Classical indications for androgen therapy in males are represented by primary or secondary hypogonadism, delayed puberty, aplastic anemia and that secondary to chronic renal failure, protein wasting diseases such as trauma, burns, tumors and infectious diseases. Androgen innovating applications in men are represented by aging and visceral obesity associated with the metabolic syndrome. In addition, it is clear that appropriate testosterone treatment can be adequately used in male contraception, provided spermatogenesis is abolished and tolerability is adequate. Due to unphysiological hormone levels achieved by currently available testosterone preparations, new delivery systems have been produced to achieve more physiological and sustained hormone levels and improve tolerability and action at the levels of target tissues. Some of them are now available in several countries and new formulas are under development.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Gambineri A,Pasquali Rdoi
10.1007/BF03343707keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
196-214issue
3eissn
0391-4097issn
1720-8386journal_volume
23pub_type
杂志文章,评审abstract：BACKGROUND:The aim of this study is to analyze our preliminary results from minimally invasive video-assisted parathyroidectomy (MIVAP) and demonstrate the feasibility of MIVAP also in non-referral centers. MATERIAL AND METHODS:During a period from June 2005 to January 2008, in the General Surgery Department of Univer...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345701
更新日期：2009-02-01 00:00:00
abstract：:EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men s...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345096
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01441-z
更新日期：2020-10-09 00:00:00
abstract：:The effects of growth hormone-releasing hormone (GHRH) were studied on densely granulated somatotroph adenoma cells and sparsely granulated somatotroph adenoma cells in culture by measuring release of growth hormone (GH) as well as ultrastructural morphometrical parameters and comparing them with those of control aden...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350727
更新日期：1989-07-01 00:00:00
abstract：:The research suggests that adiponectin plays an important role in sensitizing insulin action. It is interesting to find that the lower levels of adiponectin exist in the plasma of obese and Type 2 diabetes subjects and in the adipose tissue of obese, db/db mice, and insulin-resistant individuals. However, the underlyi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346688
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines. METHODS:In this comparative case-control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0650-x
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:The diagnosis of polycystic ovary syndrome (PCOS) is based on a combination of various clinical phenotypes in each patient. However, insulin resistance (IR) and dysmetabolism are not included in the diagnostic criteria of PCOS. Therefore, the definition of PCOS is controversial. The objective of this study is t...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0902-4
更新日期：2018-12-01 00:00:00
abstract：AIM:To evaluate if nutritional intakes and lipid profile fulfill international guidelines and recommendations before and after a structured dietician training to a Mediterranean- style diet in an Italian pediatric population with Type 1 diabetes. METHODS:A 6-month prospective cohort study. Baseline and after-intervent...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.3275/7755
更新日期：2012-02-01 00:00:00
abstract：:We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the up...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347433
更新日期：2007-03-01 00:00:00
abstract：COPEPTIN:Copeptin is secreted in equimolar amount to Arginine Vasopressin (AVP) but can easily be measured with a sandwich immunoassay. Both peptides, copeptin and AVP, show a high correlation. Accordingly, copeptin mirrors the amount of AVP in the circulation and its measurement provides an attractive marker in the di...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-019-01087-6
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The data about cardiovascular (CV) changes in patients with asymptomatic primary hyperparathyroidism (PHPT) are scarce. AIM:The aim of this study is to compare cardiac structure and functions in patients with asymptomatic PHPT and controls by using tissue Doppler echocardiography. SUBJECTS AND METHODS:Thir...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8961
更新日期：2013-11-01 00:00:00
abstract：:Aromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase activity tended to be high in the proliferative cells compared to the secretory...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349962
更新日期：1989-03-01 00:00:00
abstract：:A 39-year-old Danish woman was treated with an oral dose of 400 MBq 131I for a non-toxic goiter with compression symptoms. Serum anti-TPO and TSH receptor antibodies were negative before radioiodine therapy. The patient developed hyperthyroidism four months after treatment and ophthalmopathy after another three months...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343594
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345623
更新日期：2008-07-01 00:00:00
abstract：:The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349485
更新日期：1984-12-01 00:00:00
abstract：BACKGROUND:Fine needle cytology aspirates (FNA) classified as THY4 are a heterogeneous group suspicious for malignancy [papillary thyroid cancer (PTC)], which is confirmed in 50-80% of cases after surgery. AIM:To better stratify THY4 FNA specimens for the relative risk of malignancy. METHODS:We retrospectively analyz...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8958
更新日期：2013-11-01 00:00:00
abstract：:Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, bu...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345259
更新日期：2003-11-01 00:00:00
abstract：:Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Type 1 diabetes (T1DM) is an autoimmune disease in which both genetic and environmental factors play a role in the etiology. AIM:The aim of this study was to analyze the incidence of T1DM. METHODS:A retrospective technique was used to register all newly diagnosed cases of T1DM in Belgrade (Serbia) children...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,多中心研究
doi：10.3275/8619
更新日期：2013-05-01 00:00:00
abstract：:Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347667
更新日期：1993-02-01 00:00:00
abstract：:The renin-angiotensin-aldosterone system (RAAS) plays a well-recognized role in the regulation of BP and in salt and water balance. Since hypertension affects a considerable proportion of obese patients, circulating RAAS has been studied in obese subjects with and without hypertension, albeit with conflicting results....
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344010
更新日期：2002-04-01 00:00:00
abstract：AIMS AND METHODS:Factor analysis is a multivariate correlation technique frequently employed to characterise the aggregation of abnormalities underlying the metabolic syndrome (MS), but scarcely used in obese adolescents. Aim of the study was to investigate the clustering of anthropometric and metabolic variables relat...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346506
更新日期：2009-06-01 00:00:00
abstract：:Ketoacidosis is a metabolic alteration caused by absolute or relative insulin deficiency and oversecretion of glucagon. Prompt diagnosis and rapid initiation of treatment are mandatory to avoid the complications and fatal outcome. Reduction of plasma glucose to levels within acceptable limits, block of ketogenesis, re...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:We examined the distribution of nuclear T3 in mature rat brain with the aim of determining specific targets of thyroid hormones within this tissue. Saturation experiments, performed in 9 different structures of the brain and in 4 parts of the cortex, revealed the presence of a single class of binding sites with a mean...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348511
更新日期：1985-08-01 00:00:00
abstract：:Although the role of biogenic amines in the regulation of gonadotropin release has been studied extensively, the precise role of dopamine (DA) in stimulating LHRH and/or LH release is still controversial. In the present study 6 eugonadal women, aged 20-30, were given an LHRH infusion on day 6 of the menstrual cycle an...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349415
更新日期：1981-01-01 00:00:00
abstract：:Adolescent girls with a history of premature pubarche have an increased incidence of functional ovarian hyperandrogenism [a form of polycystic ovary syndrome (PCOS)] at adolescence, which is usually associated with hyperinsulinemia and dyslipemia. The hyperinsulinemia and lipid disturbances can often be detected in th...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03350781
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347393
更新日期：2007-01-01 00:00:00
abstract：:Typical modifications of cardiovascular activity and water and salt homeostasis throughout female reproductive life are well known. Differences in plasma levels of calcitonin gene-related peptide (CGRP) and atrial natriuretic peptide (ANP) have been observed in conditions characterized by different estrogenic levels, ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347311
更新日期：1998-04-01 00:00:00
abstract：:The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345367
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Cadmium (Cd) is a widespread environmental pollutant that causes alterations in human health acting as endocrine disruptor. Recent data suggest that cardiovascular system might be a contamination target tissue, since Cd is found in atheromatic plaques. Thus, the purpose of this study was to evaluate the cons...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0982-1
更新日期：2019-06-01 00:00:00
