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EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.

Abstract：

:EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute i.v. EP1572 administration (1.0 microg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Broglio F,Boutignon F,Benso A,Gottero C,Prodam F,Arvat E,Ghè C,Catapano F,Torsello A,Locatelli V,Muccioli G,Boeglin D,Guerlavais V,Fehrentz JA,Martinez J,Ghigo E,Deghenghi R

doi

10.1007/BF03345096

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

RC26-8

issue

8

eissn

0391-4097

issn

1720-8386

pii

5874

journal_volume

25

pub_type

杂志文章

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