Recombinant matrix metalloproteinase-14 catalytic domain induces apoptosis in human osteoblastic SaOS-2 cells.

abstract：:Glucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer,...

journal_title：Journal of endocrinological investigation

authors： Güven M,Hatemi H,Taşan E,Altuntaş Y,Ulutin T,Tezcan V,Kanigür-Sultuybek G

更新日期：1998-11-01 00:00:00

abstract：:In obesity there is a clear reduction of both spontaneous and stimulated GH secretion. Furthermore, in obese patients the somatotrope responsiveness to provocative stimulation is selectively refractory to the inhibitory effect of glucose load. It has been hypothesized that hyperinsulinism of obese patients could play ...

journal_title：Journal of endocrinological investigation

authors： Limone P,Oleandri SE,Ajmone Catt P,Grottoli S,Frangioni C,Avogadri E,Perrin M,Valetto MR,Maccario M

更新日期：1997-11-01 00:00:00

abstract：:The aim of this study was to investigate the role of multimodality treatment in patients with anaplastic thyroid carcinoma. From 1992 to 1999, 39 consecutive patients with a histologically or cytologically proven anaplastic thyroid carcinoma were referred to the Thyroid Center of Padua General Hospital. There were 28 ...

journal_title：Journal of endocrinological investigation

authors： Busnardo B,Daniele O,Pelizzo MR,Mazzarotto R,Nacamulli D,Devido D,Mian C,Girelli ME

更新日期：2000-12-01 00:00:00

abstract：:The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to...

journal_title：Journal of endocrinological investigation

authors： Bolu SE,Orkunoglu Suer FE,Deniz F,Uckaya G,Imirzalioglu N,Kutlu M

更新日期：2005-10-01 00:00:00

abstract：:During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed sign...

journal_title：Journal of endocrinological investigation

authors： Carta Sorcini M,Diodato A,Fazzini C,Sabini G,Carta S,Grandolfo ME,Guidi M,Vasta M,Locatelli De Maestri J,Donati L

更新日期：1988-04-01 00:00:00

abstract：:To evaluate the influence of chronological age and pubertal development on the hypothalamus-pituitary-adrenal (HPA) axis response to stress, we studied the possible correlations between male pubertal characteristics and salivary cortisol (C), DHEAS and the DHEAS/C ratio before (pre-stress) and after acute exercise-str...

journal_title：Journal of endocrinological investigation

authors： Di Luigi L,Guidetti L,Baldari C,Gallotta MC,Sgrò P,Perroni F,Romanelli F,Lenzi A

更新日期：2006-10-01 00:00:00

abstract：:Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...

journal_title：Journal of endocrinological investigation

authors： Ajlouni KM,Sliman NA,Najdawi A,Abu-Hajir MM,Arnaout MA

更新日期：1988-09-01 00:00:00

abstract：:In a 41-year-old hirsute woman, severe hypercalcemia led to the discovery of hyperparathyroidism related to the involvement (hyperplasia/or adenoma) of the 4 parathyroid glands. Plasma and urinary DHA, plasma DHA-sulfate and delta 5 steroid precursors were elevated. Steroid hormone hypersecretion was stimulated by hCG...

journal_title：Journal of endocrinological investigation

authors： Guillausseau PJ,Boitard C,Le Charpentier Y,Cedard L,Nahoul K,Blacker C,Kaloustian E,Courtalhac-Kaloustian F,Dubost C,Lubetzki J

更新日期：1987-12-01 00:00:00

abstract：:The last decade has witnessed an upsurge of interest in the research on facial attractiveness. The development of computer graphics has allowed to objectively investigate the conserved features of attractive faces. Averageness, symmetry and sex-specific traits have been associated with attractiveness. The effect of av...

journal_title：Journal of endocrinological investigation

authors： Cellerino A

更新日期：2003-01-01 00:00:00

abstract：:Patients with Cushing syndrome have elevated 24 h urinary free cortisol excretion and loss of diurnal rhythm of plasma cortisol, however, morning total plasma cortisol concentrations are often similar to those of normal individuals. To test the hypothesis that an elevated morning plasma free cortisol could distinguish...

journal_title：Journal of endocrinological investigation

authors： Friedman TC,Yanovski JA

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:We recently demonstrated a protective effect of the farnesoid X receptor agonist obeticholic acid (OCA) in rat models of bleomycin-induced pulmonary fibrosis (PF). Aim of the present study was to investigate whether the positive effects of OCA treatment are apparent also on ongoing bleomycin-induced PF, i.e., a...

journal_title：Journal of endocrinological investigation

authors： Comeglio P,Filippi S,Sarchielli E,Morelli A,Cellai I,Corno C,Pini A,Adorini L,Vannelli GB,Maggi M,Vignozzi L

更新日期：2019-03-01 00:00:00

abstract：:GH has a pivotal role in maintaining bone mass and metabolism both during childhood and in adult life. This effect depends on a complex interaction between circulating and peripherically produced GH and IGF-I. In vitro data and the use of genetically modified animals have greatly expanded the understanding of regulato...

journal_title：Journal of endocrinological investigation

authors： Bogazzi F,Cosci C,Sardella C,Martino E,Gasperi M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...

journal_title：Journal of endocrinological investigation

authors： Lin Y,Xu Y,Chen G,Huang B,Chen Z,Yao L,Chen Z

更新日期：2012-01-01 00:00:00

abstract：:Microvessel density (MVD) represents a measure of angiogenesis and may be used as an indicator of neoplastic aggressiveness. Vascular endothelial growth factor (VEGF) plays a pivotal role as angiogenic promoter by stimulating endothelial cell proliferation and migration and enhancing vascular permeability. The aim of ...

journal_title：Journal of endocrinological investigation

authors： Viacava P,Gasperi M,Acerbi G,Manetti L,Cecconi E,Bonadio AG,Naccarato AG,Acerbi F,Parenti G,Lupi I,Genovesi M,Martino E

更新日期：2003-01-01 00:00:00

abstract：:Disulfide bonds are formed between the sulfhydryl groups in two cysteine residues of a protein. The formation of these bonds is necessary for the proper folding of a protein into its active three-dimensional form. In this study, the genes associated with disulfide bond formation of proteins from the rat thyroid cell l...

journal_title：Journal of endocrinological investigation

authors： Park S,Hwang I,Shong M,Kwon OY

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Studies from every continent have shown that only around 50% of the patients subjected to thyroid hormone replacement have TSH in the normal range. However, to date, there are no consistent data about Brazil. OBJECTIVES:To evaluate levothyroxine (LT4) replacement treatment in patients with primary hypothyro...

journal_title：Journal of endocrinological investigation

authors： Vaisman F,Coeli CM,Ward LS,Graf H,Carvalho G,Montenegro R Jr,Vaisman M

更新日期：2013-07-01 00:00:00

abstract：:Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...

journal_title：Journal of endocrinological investigation

authors： Frajese GV,Pozzi F

更新日期：2005-01-01 00:00:00

abstract：:The adrenomedullary response to stimuli is often elevated in poorly controlled insulin dependent diabetic patients, and it is controversial whether the adrenomedullary hyperactivity induces the suppression of the circadian rhythm of catecholamines. We have studied the urinary excretion of catecholamines in 11 diabetic...

journal_title：Journal of endocrinological investigation

authors： Del Rio G,Carani C,Baldini A,Marrama P,Della Casa L

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...

journal_title：Journal of endocrinological investigation

authors： Mannucci E,Alegiani SS,Monami M,Sarli E,Avogaro A,DAI (Diabetes and Informatics) Study Group.

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrinopathy-candidiasis-ectodermal-dystrophy (APECED) or autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive genetic disease due to mutations in the AIRE (AutoImmune REgulator) gene. The clinical diagnosis is classically based on the presence of at least two of th...

journal_title：Journal of endocrinological investigation

authors： Fierabracci A,Arena A,Toto F,Gallo N,Puel A,Migaud M,Kumar M,Chengappa KG,Gulati R,Negi VS,Betterle C

更新日期：2020-08-07 00:00:00

abstract：:Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...

journal_title：Journal of endocrinological investigation

authors： Hirsch D,Benbassat CA,Drozd T,Okon E,Blum I

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:Primary hyperparathyroidism has deleterious effects on health and causes nephrolithiasis and osteoporosis. However, it remains unclear whether parathyroidectomy benefits kidney function among patients with primary hyperparathyroidism. METHODS:In this retrospective study, patients with primary hyperparathyroidi...

journal_title：Journal of endocrinological investigation

authors： Liang CC,Yeh HC,Lo YC,Chou CY,Yen TH,Tsai HC,Hsu SP,Kuo CC

更新日期：2020-07-29 00:00:00

abstract：AIMS AND METHODS:Factor analysis is a multivariate correlation technique frequently employed to characterise the aggregation of abnormalities underlying the metabolic syndrome (MS), but scarcely used in obese adolescents. Aim of the study was to investigate the clustering of anthropometric and metabolic variables relat...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Adorni F,Agosti F,De Col A,Zennaro R,Caranti D,Sartorio A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:While it is now accepted that genes and their products affect food intake, the concept that locomotor behavior or the propensity for physical activity is controlled by neuro hum oral regulators is frequently underappreciated. In mammals, complex interactions have developed to allow the cross-talk between fue...

journal_title：Journal of endocrinological investigation

authors： Ceccarini G,Maffei M,Vitti P,Santini F

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I...

journal_title：Journal of endocrinological investigation

authors： Toia M,Galazzo R,Maioli C,Granata R,Scarlatti F

更新日期：2005-12-01 00:00:00

abstract：:The association of several risk factors, obesity, dyslipoproteinemia, hepatic steatosis, insulin resistance and hypertension with Type 2 (non-insulin-dependent) diabetes mellitus and myocardial infarction has long been known and has been termed the "metabolic syndrome". In 1988 Reaven introduced syndrome X as the link...

journal_title：Journal of endocrinological investigation

authors： Johannsson G,Bengtsson BA

更新日期：1999-01-01 00:00:00

abstract：:Exhaustive graded exercise leads to changes of hormones, carbohydrate, and lipid metabolism in normal controls and obese patients after prolonged starvation. Concomitant with a large increase of plasma catecholamines, insulin concentration is reduced and blood glucose levels slowly increase. More glucose is made avail...

journal_title：Journal of endocrinological investigation

authors： Jakober B,Schmülling RM,Müller PH,Eggstein M

更新日期：1983-12-01 00:00:00

abstract：:Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Pr...

journal_title：Journal of endocrinological investigation

authors： Marcovecchio M,Mohn A,Chiarelli F

更新日期：2005-10-01 00:00:00

abstract：:Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper under...

journal_title：Journal of endocrinological investigation

authors： Pendin D,Greotti E,Filadi R,Pozzan T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In the last decades, a higher incidence of congenital hypothyroidism (CH) has been recorded in Italy (1:1940) and worldwide, mainly due to the shift to lower screening TSH cutoffs. Although CH can also be caused by dysgenetic defects, most CH cases have recently been found to be more frequently associated wi...

journal_title：Journal of endocrinological investigation

authors： Vigone MC,Di Frenna M,Weber G

更新日期：2015-08-01 00:00:00