Abstract:
BACKGROUND:Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM:We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala588Thr) polymorphisms in exon 12 of the HIF-1α gene are associated with pre-eclampsia. SUBJECTS AND METHODS:Subjects included 163 pre-eclamptic patients (48 mild and 115 severe preeclampsia) and 194 healthy pregnant women. Polymorphisms were genotyped by PCR and direct DNA sequencing. RESULTS:There were no significant differences in genotype or allele frequencies of the c.1772C>T and c.1790G>A polymorphisms of the HIF-1α gene among the study groups. Moreover, subgroup analysis according to pre-eclampsia severity revealed no significant differences in genotype or allele frequencies of the HIF-1α c.1772C>T and c.1790G>A polymorphism in mild pre-eclamptic compared to severe pre-eclamptic group. In addition, there were no significant differences in the frequencies of 3 haplotypes (C-G,-G, T-G, and C-A) between the control and pre-eclamptic groups. CONCLUSIONS:Our results suggest that the HIF-1α gene polymorphisms are not associated with the development of pre-eclampsia in the studied Korean women population.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Kim SY,Park SY,Lim JH,Lee BY,Yang JH,Ryu HMdoi
10.3275/8009subject
Has Abstractpub_date
2012-07-01 00:00:00pages
670-5issue
7eissn
0391-4097issn
1720-8386pii
8009journal_volume
35pub_type
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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更新日期:1990-09-01 00:00:00