Differential Metabolic Alterations and Biomarkers Between Gastric Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis.

abstract：Background:Long non-coding RNAs (lncRNAs) have been verified to have a vital role in the progression of glioblastoma multiforme (GBM). Our research was about to identify the potential lncRNAs which was closely associated with the pathogenesis and prognosis of glioblastoma multiforme. Methods:All RNA sequence profiling...

journal_title：OncoTargets and therapy

authors： Li Y,Guo D

更新日期：2020-02-04 00:00:00

abstract：Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...

journal_title：OncoTargets and therapy

authors： Shi H,Luo K,Huang W

更新日期：2020-08-26 00:00:00

abstract：Background:Nicotinamide phosphoribosyltransferase (NAMPT) and the transforming growth factor-β (TGF-β) signaling pathway play important roles in colorectal tumorigenesis and progress. However, the underlying regulatory mechanisms between NAMPT and TGF-β signaling in colorectal cancer (CRC) remain poorly understood. Me...

journal_title：OncoTargets and therapy

authors： Lv X,Zhang J,Zhang J,Guan W,Ren W,Liu Y,Xu G

更新日期：2021-01-08 00:00:00

abstract：Objective:The role of neoadjuvant therapy (NAT) in resectable pancreatic cancer (RPC) remains controversial. Therefore, this meta-analysis was performed to compare the clinical differences between NAT and upfront surgery in RPC. Materials and methods:A systematic literature search was performed in PubMed, Embase, Web ...

journal_title：OncoTargets and therapy

authors： Ren X,Wei X,Ding Y,Qi F,Zhang Y,Hu X,Qin C,Li X

更新日期：2019-01-22 00:00:00

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：:Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radio...

journal_title：OncoTargets and therapy

authors： Burdick MJ,Macklis RM

更新日期：2009-02-18 00:00:00

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：Objective:Osteoclastogenesis is a key process in osteolytic bone metastasis (BM). Previous studies indicated that some miRNAs could regulate cancers progression and osteoclastogenesis. Our purpose was to investigate the roles of lung cancer cells-derived circulating miR-21 on osteoclastogenesis and its clinical signifi...

journal_title：OncoTargets and therapy

authors： Zhao Q,Liu C,Xie Y,Tang M,Luo G,Chen X,Tian L,Yu X

更新日期：2020-03-31 00:00:00

abstract：:In the absence of a driver mutation, chemotherapy is the standard treatment option as first- and second-line therapy for advanced non-small-cell lung cancer (NSCLC). Though a large number of patients are suitable for post second-line therapies, the quality and quantity of the available drugs in this setting is poor. A...

journal_title：OncoTargets and therapy

authors： Fang SC,Zhang HT,Zhang YM,Xie WP

更新日期：2017-01-18 00:00:00

abstract：:The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...

journal_title：OncoTargets and therapy

authors： Sun Y,Tao C,Huang X,He H,Shi H,Zhang Q,Wu H

更新日期：2016-05-12 00:00:00

abstract：Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...

journal_title：OncoTargets and therapy

authors： Huang J,Zou Q,Qian D,Zhou L,Yang B,Chu J,Pang Q,Wang K,Zhang F

更新日期：2017-12-08 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：:N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However, the specific expression and pro- or anti-cancer role ...

journal_title：OncoTargets and therapy

authors： Wang JY,Chen LJ,Qiang P

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVES:Long non-coding RNA (lncRNA) associated with microvascular invasion in hepatocellular carcinoma (MVIH) has been recently reported to act as a predictor for the poor recurrence-free survival of hepatocellular carcinoma (HCC) after hepatectomy. However, the biological role of MVIH in the tumorigenesis of HCC i...

journal_title：OncoTargets and therapy

authors： Shi Y,Song Q,Yu S,Hu D,Zhuang X

更新日期：2015-08-27 00:00:00

abstract：Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...

journal_title：OncoTargets and therapy

authors： Bimonte S,Barbieri A,Cascella M,Rea D,Palma G,Del Vecchio V,Forte CA,Del Prato F,Arra C,Cuomo A

更新日期：2018-01-03 00:00:00

abstract：:Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...

journal_title：OncoTargets and therapy

authors： Gogakos AS,Paliouras D,Asteriou C,Rallis T,Lazopoulos A,Chatzinikolaou F,Zissimopoulos A,Tsavlis D,Tsirgogianni K,Zarogoulidis K,Porpodis K,Tsakiridis K,Pitsiou G,Kioumis I,Karapantzos I,Karapantzou C,Sachpekidis N,Zaro

更新日期：2016-01-18 00:00:00

abstract：Background:Several intracellular signaling pathways that are deregulated during hepatocarcinogenesis might constitute potential targets for hepatocellular carcinoma (HCC) therapy. The aim of this study was to test the potential synergic antitumor effect of salirasib and sorafenib in a diethylnitrosamine (DEN)-induced H...

journal_title：OncoTargets and therapy

authors： Ciccarelli O,Colson A,De Saeger C,Reding R,Sempoux C,Leclercq IA,Stärkel P

更新日期：2018-10-17 00:00:00

abstract：OBJECTIVE:To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features and prognosis in HCC patients. MATERIALS AND METHODS:A total of 128 HCC patients who received radical resection were en...

journal_title：OncoTargets and therapy

authors： Wang J,Liu F,Ao P,Li X,Zheng H,Wu D,Zhang N,She J,Yuan J,Wu X

更新日期：2016-09-09 00:00:00

abstract：:This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three lung adenocarcinoma associated datasets (GSE43458, GSE10072, and GSE50081), the subjects of which included smokers and nonsmokers, were downloaded to screen the differentially expressed feature genes between ...

journal_title：OncoTargets and therapy

authors： Liu Y,Ni R,Zhang H,Miao L,Wang J,Jia W,Wang Y

更新日期：2016-12-07 00:00:00

abstract：:Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of the cell membrane in various immune cells, such as dendritic c...

journal_title：OncoTargets and therapy

authors： Zhu P,Hu C,Hui K,Jiang X

更新日期：2017-09-01 00:00:00

abstract：Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...

journal_title：OncoTargets and therapy

authors： Chen Q,Yuan H,Shi GD,Wu Y,Liu DF,Lin YT,Chen L,Ge WL,Jiang K,Miao Y

更新日期：2018-05-09 00:00:00

abstract：Background:Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therapy is usually at high intensity, and contact or even invasive electrodes are typically used, which may cause unwanted side effects. ...

journal_title：OncoTargets and therapy

authors： Lu CH,Lin SH,Hsieh CH,Chen WT,Chao CY

更新日期：2018-08-10 00:00:00

abstract：Purpose:Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX. Methods:Microarray analysis was used to identify differentially expressed genes in pacl...

journal_title：OncoTargets and therapy

authors： Guo M,Li S,Zhao X,Yuan Y,Zhang B,Guan Y

更新日期：2020-12-24 00:00:00

abstract：Introduction:The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated f...

journal_title：OncoTargets and therapy

authors： Liao W,Zhang L,Zhong Y,Shen Y,Li C,An N

更新日期：2018-04-05 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00

abstract：Background:New evidence suggests that histidine triad nucleotide-binding protein 1 (Hint1) exerts a tumor suppressor effect in various human tumors, such as colorectal cancer and gastric cancer. However, it has not been reported whether Hint1 is involved in the occurrence and development of osteosarcoma (OS). Material...

journal_title：OncoTargets and therapy

authors： Duan DD,Xie H,Shi HF,Huang WW,Ding F,Hong JK,Fan JS,Hu SY,Wang QW,Zhou MQ

更新日期：2020-08-19 00:00:00

abstract：Introduction:Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and the sensitization of cells to chemo- and radiotherapy. In this study, we explored the antitumor pr...

journal_title：OncoTargets and therapy

authors： Qiu C,Zhang X,Huang B,Wang S,Zhou W,Li C,Li X,Wang J,Yang N

更新日期：2020-10-20 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00