Enhanced anticancer effects of low-dose curcumin with non-invasive pulsed electric field on PANC-1 cells.

abstract：BACKGROUND:This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC). METHODS:PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure datab...

journal_title：OncoTargets and therapy

authors： Zhang Y,Zhu SL,Chen J,Li LQ

更新日期：2016-05-30 00:00:00

abstract：Introduction:Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small sp...

journal_title：OncoTargets and therapy

authors： Tan Y,Lu X,Cheng Z,Pan G,Liu S,Apiziaji P,Wang H,Zhang J,Abulimiti Y

更新日期：2020-08-13 00:00:00

abstract：Objective:The phenomenon that cancer cells avidly exhibit glycolysis with lactate secretion and decrease in mitochondrial activity under aerobic conditions is known historically as the Warburg effect. Rho GTPase-activating protein 4 (ARHGAP4) is an important negative regulator of the Rho signaling pathway that was asso...

journal_title：OncoTargets and therapy

authors： Shen Y,Chen G,Zhuang L,Xu L,Lin J,Liu L

更新日期：2019-06-28 00:00:00

abstract：Background:Bladder cancer is a serious threat to human health. It is meaningful to study the pathogenesis of bladder cancer. Long non-coding RNAs (lncRNAs) are reported to promote or inhibit bladder cancer development. However, the role of lncRNA BCAR4 in the regulation of bladder cancer remains unclear. Purpose:This ...

journal_title：OncoTargets and therapy

authors： Wang X,He H,Rui W,Xie X,Wang D,Zhu Y

更新日期：2020-03-24 00:00:00

abstract：PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...

journal_title：OncoTargets and therapy

authors： Cruceru ML,Enciu AM,Popa AC,Albulescu R,Neagu M,Tanase CP,Constantinescu SN

更新日期：2013-11-29 00:00:00

abstract：Background:KIF18B was identified as a potential oncogene by analysis of The Cancer Genome Atlas database. Materials and methods:We assessed KIF18B expression and explored its clinical significance in cervical cancer tissues. We have also evaluated the effects of KIF18B on cervical cancer cell proliferation, migration,...

journal_title：OncoTargets and therapy

authors： Wu Y,Wang A,Zhu B,Huang J,Lu E,Xu H,Xia W,Dong G,Jiang F,Xu L

更新日期：2018-03-28 00:00:00

abstract：Background:PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-relat...

journal_title：OncoTargets and therapy

authors： He W,Zhang X,Li W,Kong C,Wang Y,Zhu L,Xu R,Deng G,Zhang P

更新日期：2018-10-24 00:00:00

abstract：OBJECTIVE:Resveratrol is a phytoestrogen with various antiproliferative and proapoptotic effects. This in vitro study aimed to analyze the effect of resveratrol on the viability and expression of modulators of apoptosis in GH3 pituitary adenoma cells of the rat. METHODS:GH3 cells were incubated with resveratrol concen...

journal_title：OncoTargets and therapy

authors： Voellger B,Kirches E,Wilisch-Neumann A,Weise A,Tapia-Perez JH,Rupa R,Mawrin C,Firsching R

更新日期：2013-09-16 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：PURPOSE:Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characterist...

journal_title：OncoTargets and therapy

authors： Qian Y,Ding T,Wei L,Cao S,Yang L

更新日期：2016-05-04 00:00:00

abstract：OBJECTIVE:Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, the aim was to investigate the effects of emodin on EOC cells and to study fu...

journal_title：OncoTargets and therapy

authors： Lu J,Xu Y,Zhao Z,Ke X,Wei X,Kang J,Zong X,Mao H,Liu P

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR) has been reported to be a comparable alternative therapy to surgery for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). However, it has not been clarified whether SBRT/SABR is as effective as surgery. We conducted t...

journal_title：OncoTargets and therapy

authors： Li M,Yang X,Chen Y,Yang X,Dai X,Sun F,Zhang L,Zhan C,Feng M,Wang Q

更新日期：2017-06-07 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has been the mainstay ...

journal_title：OncoTargets and therapy

authors： Li GZ,Raut CP

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：Introduction:Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and the sensitization of cells to chemo- and radiotherapy. In this study, we explored the antitumor pr...

journal_title：OncoTargets and therapy

authors： Qiu C,Zhang X,Huang B,Wang S,Zhou W,Li C,Li X,Wang J,Yang N

更新日期：2020-10-20 00:00:00

abstract：Introduction:Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tum...

journal_title：OncoTargets and therapy

authors： Lu Q,Wang X,Zhu J,Fei X,Chen H,Li C

更新日期：2020-11-18 00:00:00

abstract：Background:Growing evidence suggests that miR-150 plays an inhibitory role in various types of cancer. However, the function and underlying mechanisms of miR-150 in triple-negative breast cancer (TNBC) remain unknown. Patients and methods:miR-150 expression was detected by qRT-PCR and ISH in TNBC tumor and adjacent no...

journal_title：OncoTargets and therapy

authors： Tang W,Xu P,Wang H,Niu Z,Zhu D,Lin Q,Tang L,Ren L

更新日期：2018-04-24 00:00:00

abstract：Background:Investigating the roles of lncRNA prostate cancer-associated transcript 6 (PCAT6) in modulating the growth and aggressiveness of non-small-cell lung carcinoma (NSCLC) cell. Method:The levels of PCAT6 in NSCLC tissues and cell lines were determined by quantitative real-time PCR assay. MTT as well as colony f...

journal_title：OncoTargets and therapy

authors： Cui LH,Xu HR,Yang W,Yu LJ

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Permanent prostate brachytherapy (PPB) is an effective treatment choice for low and intermediate risk prostate cancer (PCa). However, the impact of PPB on tumor immune status is still poorly understood. This study aimed to assess the immune status in PCa patients before and at different time points after PPB...

journal_title：OncoTargets and therapy

authors： Du E,Wang L,Li CY,Zhang CW,Qu YC,Liu RL,Xu Y,Yang K,Zhang ZH

更新日期：2017-05-15 00:00:00

abstract：:Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...

journal_title：OncoTargets and therapy

authors： Song XY,Li BY,Zhou EX,Wu FX

更新日期：2016-08-26 00:00:00

abstract：OBJECTIVES:PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. PATIENTS AND METHODS:We performed immunohistochemical stain...

journal_title：OncoTargets and therapy

authors： Chang H,Kim JS,Choi YJ,Cho JG,Woo JS,Kim A,Kim JS,Kang EJ

更新日期：2017-06-13 00:00:00

abstract：Background and aim:Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with n...

journal_title：OncoTargets and therapy

authors： Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR

更新日期：2017-11-10 00:00:00

abstract：Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...

journal_title：OncoTargets and therapy

authors： Tian J,Xue W,Yin H,Zhang N,Zhou J,Long Z,Wu C,Liang Z,Xie K,Li S,Li L,Wu Z,Daria V,Zhao Y,Wang F,Wang M

更新日期：2020-06-25 00:00:00

abstract：Purpose:Based on the continuous exploration of solid tumor immunotherapy, we focused on hepatocellular carcinoma with a high level of morbidity and mortality. We confirm the stability of mcDNA-based CAR T cell generating platform, and investigate the antitumor activity of CD44-CAR T cells against hepatocellular carcino...

journal_title：OncoTargets and therapy

authors： Wang H,Ye X,Ju Y,Cai Z,Wang X,Du P,Zhang M,Li Y,Cai J

更新日期：2020-05-04 00:00:00

abstract：:Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). The...

journal_title：OncoTargets and therapy

authors： Martin JM,Goldstein LJ

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isofor...

journal_title：OncoTargets and therapy

authors： Vicari L,La Rosa C,Forte S,Calabrese G,Colarossi C,Aiello E,Salluzzo S,Memeo L

更新日期：2016-10-11 00:00:00

abstract：:Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....

journal_title：OncoTargets and therapy

authors： Yi F,Du J,Ni W,Liu W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:"Gefitinib" is a first-generation epidermal growth factor receptor tyrosine-kinase inhibitor. More than half of patients receiving gefitinib develop acne-like eruption. Evozac(®) Calming Skin Spray (Evaux Laboratoires, Évaux-les-Bains, France) is made of Évaux thermal spring water and commonly used for the t...

journal_title：OncoTargets and therapy

authors： Wang Y,Yang Y,Xu J,Yu J,Liu X,Gao R,Zhang L

更新日期：2014-07-10 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...

journal_title：OncoTargets and therapy

authors： Yang P,Xu ZP,Chen T,He ZY

更新日期：2016-04-26 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S262089.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-11-27 00:00:00