Differential expression of two activating transcription factor 5 isoforms in papillary thyroid carcinoma.

abstract：Purpose:The proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological ...

journal_title：OncoTargets and therapy

authors： Wang Z,Li M,Huang Y,Ma L,Zhu H,Kong L,Yu J

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:Paxillin is implicated in tumorigenesis, progression and aggressive phenotypes of various malignancies, highlighting its functions in cellular adhesion, migration and survival. However, the roles of paxillin in human gliomas remain unclear. The aim of this study was to evaluate the clinical implication of pa...

journal_title：OncoTargets and therapy

authors： Chen B,Xia L,Xu CS,Xiao F,Wang YF

更新日期：2016-11-09 00:00:00

abstract：Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...

journal_title：OncoTargets and therapy

authors： Chen PF,Wang F,Nie JY,Feng JR,Liu J,Zhou R,Wang HL,Zhao Q

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...

journal_title：OncoTargets and therapy

authors： Boselli C,Renzi C,Gemini A,Castellani E,Trastulli S,Desiderio J,Corsi A,Barberini F,Cirocchi R,Santoro A,Parisi A,Redler A,Noya G

更新日期：2013-01-01 00:00:00

abstract：Introduction:Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tum...

journal_title：OncoTargets and therapy

authors： Lu Q,Wang X,Zhu J,Fei X,Chen H,Li C

更新日期：2020-11-18 00:00:00

abstract：Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...

journal_title：OncoTargets and therapy

authors： Zhou JH,Yao ZX,Zheng Z,Yang J,Wang R,Fu SJ,Pan XF,Liu ZH,Wu K

更新日期：2020-09-30 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：:Melanoma develops from melanocytes and typically occurs on the skin and mucosa with a high degree of malignancy. Intensive local invasion and distant metastasis of melanoma result in poor patient prognosis, owing to frequent metastases to the lungs, bones, brains, and other parts of the body. In the present study, we ...

journal_title：OncoTargets and therapy

authors： Feng L,Qi DJ,Zhang QF

更新日期：2016-08-10 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：Purpose:Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but the underlying mechanism is still unknown. Here, we explored the role of the NRF2/KEAP1 pathway in radioresistance of NPC cell lines. Materials and Methods:We selected NPC cell lines CNE-1 and CNE-2, treated them...

journal_title：OncoTargets and therapy

authors： Zhou J,Ding J,Ma X,Zhang M,Huo Z,Yao Y,Li D,Wang Z

更新日期：2020-09-11 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Background:Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therapy is usually at high intensity, and contact or even invasive electrodes are typically used, which may cause unwanted side effects. ...

journal_title：OncoTargets and therapy

authors： Lu CH,Lin SH,Hsieh CH,Chen WT,Chao CY

更新日期：2018-08-10 00:00:00

abstract：:Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The...

journal_title：OncoTargets and therapy

authors： Tarazona N,Navarro L,Cejalvo JM,Gambardella V,Pérez-Fidalgo JA,Sempere A,Navarro S,Cervantes A

更新日期：2015-05-14 00:00:00

abstract：:CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

journal_title：OncoTargets and therapy

authors： Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

更新日期：2020-09-22 00:00:00

abstract：AIM:The aim of this study was to assess if the expression of Notch 1 receptor is associated with tumor aggressiveness in papillary thyroid carcinomas (PTCs). PATIENTS AND METHODS:By searching the electronic medical record system of Xin Hua Hospital, all cases of PTC patients who underwent thyroidectomy in the hospital...

journal_title：OncoTargets and therapy

authors： Fu H,Ma C,Guan W,Cheng W,Feng F,Wang H

更新日期：2016-03-15 00:00:00

abstract：Background:Large amounts of researches indicate that non-coding RNAs play a crucial role in many malignancies. However, the potential mechanisms of non-coding RNAs involved in osteosarcoma tumorigenesis remain elusive. Materials and Methods:The expression of long non-protein coding RNA 691 (lncRNA 691) in cell lines a...

journal_title：OncoTargets and therapy

authors： Yao P,Ni Y,Liu C

更新日期：2020-05-22 00:00:00

abstract：Background:Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysregulated in tumors and critical for tumor-cell proliferation a...

journal_title：OncoTargets and therapy

authors： Li X,Zhu G,Yao X,Wang N,Hu R,Kong Q,Zhou D,Long L,Cai J,Zhou W

更新日期：2018-12-11 00:00:00

abstract：Background and aim:Ewing sarcoma (ES) is an aggressive neoplasm predominantly occurring in adolescents and has a poor prognosis when metastasized. In the current study, we were aiming to investigate the function of TRIM3 in autophagy in ES cells. Methods:The expression of TRIM3 in Ewing sarcoma tissues and normal tiss...

journal_title：OncoTargets and therapy

authors： Lu Q,Zhang Y,Ma L,Li D,Li M,Liu P,Li J

更新日期：2019-12-30 00:00:00

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Repetitive genotyping is useful to assess the genetic evolution of non-small-cell lung cancer (NSCLC) during treatment, but the need for sampling by biopsy is a major obstacle. Digital polymerase chain reaction (PCR) is a promising procedure for the detection of mutant alleles in plasma of cancer patients. ...

journal_title：OncoTargets and therapy

authors： Nakahara Y,Takagi Y,Hosomi Y,Kagei A,Yamamoto T,Sawada T,Yomota M,Okuma Y,Mikura S,Okamura T

更新日期：2016-08-24 00:00:00

abstract：BACKGROUND:Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in...

journal_title：OncoTargets and therapy

authors： Kang FC,Chen PJ,Pan BS,Lai MS,Chen YC,Huang BM

更新日期：2015-09-01 00:00:00

abstract：Background and objective:Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored. Th...

journal_title：OncoTargets and therapy

authors： Hou Y,Lan C,Kong Y,Zhu C,Peng W,Huang Z,Zhang C

更新日期：2019-03-01 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：:[This retracts the article on p. 2215 in vol. 8, PMID: 26345468.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-02-04 00:00:00

abstract：Background:Exosomes are nano-sized biological vesicles released by many kinds of cells, which play an important role in tumor metastasis through transporting cytokines, RNAs and proteins. However, the molecular mechanisms of exosomes in hepatocellular carcinoma (HCC) metastasis are not completely understood. Materials...

journal_title：OncoTargets and therapy

authors： Qu Z,Feng J,Pan H,Jiang Y,Duan Y,Fa Z

更新日期：2019-08-23 00:00:00

abstract：OBJECTIVE:Resveratrol is a phytoestrogen with various antiproliferative and proapoptotic effects. This in vitro study aimed to analyze the effect of resveratrol on the viability and expression of modulators of apoptosis in GH3 pituitary adenoma cells of the rat. METHODS:GH3 cells were incubated with resveratrol concen...

journal_title：OncoTargets and therapy

authors： Voellger B,Kirches E,Wilisch-Neumann A,Weise A,Tapia-Perez JH,Rupa R,Mawrin C,Firsching R

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00