Primary paraesophageal Ewing's sarcoma: an uncommon case report and literature review.

abstract：Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...

journal_title：OncoTargets and therapy

authors： Li X,Li F,Wang F,Li J,Lin C,Du J

更新日期：2018-05-22 00:00:00

abstract：Background:Gastric cancer (GC) is an aggressive malignancy with high lethality. Systematic chemotherapy is the main therapeutic strategy for advanced GC patients. The overexpression of Axl is associated with poor prognosis and regulates tumor growth and metastasis in many types of cancer. However, the role of Axl in GC...

journal_title：OncoTargets and therapy

authors： He L,Lei Y,Hou J,Wu J,Lv G

更新日期：2020-06-22 00:00:00

abstract：Introduction:Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma. Met...

journal_title：OncoTargets and therapy

authors： Guo Y,Yang L,Lei S,Tan W,Long J

更新日期：2019-12-04 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：OBJECTIVE:Despite advances in the early diagnosis of gastrointestinal (GI) cancers, these cancers are often being detected rather late in their course. Emerging published data on the accuracy of dickkopf-1 (DKK1) for diagnosing GI cancers are inconsistent. The purpose of this systematic review and meta-analysis was to ...

journal_title：OncoTargets and therapy

authors： Liang B,Zhong L,He Q,Wang S,Pan Z,Wang T,Zhao Y

更新日期：2015-10-22 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consis...

journal_title：OncoTargets and therapy

authors： Shi Y,Jia R,Fan X

更新日期：2017-05-08 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：BACKGROUND:Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in...

journal_title：OncoTargets and therapy

authors： Kang FC,Chen PJ,Pan BS,Lai MS,Chen YC,Huang BM

更新日期：2015-09-01 00:00:00

abstract：Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...

journal_title：OncoTargets and therapy

authors： Bimonte S,Barbieri A,Cascella M,Rea D,Palma G,Del Vecchio V,Forte CA,Del Prato F,Arra C,Cuomo A

更新日期：2018-01-03 00:00:00

abstract：Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer p...

journal_title：OncoTargets and therapy

authors： Zhao L,Zheng Y,Ji Y,Zhang X

更新日期：2019-01-30 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：:Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics ana...

journal_title：OncoTargets and therapy

authors： Chen YH,Lin TT,Wu YP,Li XD,Chen SH,Xue XY,Wei Y,Zheng QS,Huang JB,Xu N

更新日期：2019-05-14 00:00:00

abstract：Purpose:As a novel type of non-coding RNAs, circRNAs were found to play important roles in cancer progression. In this study, we aim to investigate genome-wide circRNAs expression and potential functions in glioma to find new therapeutic targets for glioma treatment. Patients and Methods:A total of 92 pairs of glioma ...

journal_title：OncoTargets and therapy

authors： Lyu X,Zhou L,Fan F,Dong Z

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...

journal_title：OncoTargets and therapy

authors： Kong M,Hong SE

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...

journal_title：OncoTargets and therapy

authors： Van Pham P,Vu NB,Duong TT,Nguyen TT,Truong NH,Phan NL,Vuong TG,Pham VQ,Nguyen HM,Nguyen KT,Nguyen NT,Nguyen KG,Khat LT,Van Le D,Truong KD,Phan NK

更新日期：2012-01-01 00:00:00

abstract：Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...

journal_title：OncoTargets and therapy

authors： Yan Z,Yin H,Lin G

更新日期：2020-10-28 00:00:00

abstract：OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...

journal_title：OncoTargets and therapy

authors： Gong X,Wu J,Wu J,Liu J,Gu H,Shen H

更新日期：2017-01-10 00:00:00

abstract：Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...

journal_title：OncoTargets and therapy

authors： Rodrigues-Junior DM,Pelarin MFA,Nader HB,Vettore AL,Pinhal MAS

更新日期：2021-01-15 00:00:00

abstract：:Lung cancer remains the leading cause of death in cancer patients. Severe treatment side effects and late stage of disease at diagnosis continue to be an issue. We investigated whether local treatment using 2-diethylaminoethyl-dextran methyl methacrylate copolymer with p53 (DDMC-p53) with or without cisplatin and/or m...

journal_title：OncoTargets and therapy

authors： Hohenforst-Schmidt W,Zarogoulidis P,Stopek J,Vogl T,Hübner F,Turner JF,Browning R,Zarogoulidis K,Drevelegas A,Drevelegas K,Darwiche K,Freitag L,Rittger H

更新日期：2015-05-20 00:00:00

abstract：:Liver cancer is a common malignant disease in China, while the primary hepatic neuroendocrine tumor (PHNET) is extremely rare presented with various manifestations. We herein describe an interesting PHNET case, which was clinically diagnosed as hepatocellular carcinoma (HCC) based on strong clinical evidence and the n...

journal_title：OncoTargets and therapy

authors： Huang HF,Jin PP,Yang HJ,Zhang CJ,Zhang X,Wang JS,Yu JJ,Zhang B,Zhang Y,Hu QD

更新日期：2020-02-03 00:00:00

abstract：:Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...

journal_title：OncoTargets and therapy

authors： Han X,Guo X,Zhang W,Cong Q

更新日期：2019-06-20 00:00:00

abstract：INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...

journal_title：OncoTargets and therapy

authors： Sun P,Chen C,Zhang F,Yang H,Bi XW,An X,Wang FH,Jiang WQ

更新日期：2016-07-13 00:00:00

abstract：:[This retracts the article on p. 1997 in vol. 9, PMID: 27103825.][This retracts the article on p. 841 in vol. 28.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-09-20 00:00:00

abstract：Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...

journal_title：OncoTargets and therapy

authors： Fu Y,Sun X,Gu Z,Zhuang Z

更新日期：2020-06-10 00:00:00

abstract：Background:Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer...

journal_title：OncoTargets and therapy

authors： Zou YF,Rong YM,Chen ZX,Shen ZH,Chen X,Tan YX,Weng JR,Huang XM,Lin XT

更新日期：2020-08-26 00:00:00

abstract：:Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...

journal_title：OncoTargets and therapy

authors： Chaiyawat P,Settakorn J,Sangsin A,Teeyakasem P,Klangjorhor J,Soongkhaw A,Pruksakorn D

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma. METHODS:This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancero...

journal_title：OncoTargets and therapy

authors： Wang HL,Chen BB,Cao XG,Wang J,Hu XF,Mu XQ,Chen XB

更新日期：2015-05-27 00:00:00

abstract：Purpose:Tumor drug resistance limits the response to chemotherapy. Interestingly, sequential combination therapy enhances the anticancer efficacy of drugs like cisplatin (CDDP) via synergistic effects. We assayed the synergistic effects of combined photodynamic therapy programmed death receptor-ligand 1 (PDT) and chemo...

journal_title：OncoTargets and therapy

authors： Xue K,Wang YN,Zhao X,Zhang HX,Yu D,Jin CS

更新日期：2019-07-10 00:00:00

abstract：:ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...

journal_title：OncoTargets and therapy

authors： Cai C,Long Y,Li Y,Huang M

更新日期：2020-08-20 00:00:00