Abstract:
Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer patients. Methods:A total of 33 cervical cancer patients treated in our hospital from September 2012 to December 2015 were included. The mRNA expression level of STAB1 in cervical cancer tissue was determined by real-time PCR, and the patients were divided into dichotomous groups based on their SATB1 expression level. Clinical characteristics, recurrence, and survival outcomes were compared between groups. Results:Compared with the SATB1-low group, the SATB1-high group had significantly advanced International Federation of Gynecology and Obstetrics (FIGO) stages (P=0.037) and histologic grade (P=0.036). Kaplan-Meier analysis showed that SATB1-high group had a worse overall survival (P=0.078, marginal significant). In the subgroup analysis of pathological types, adenocarcinomas group (n=8) had a significantly higher SATB1 expression level as compared with the squamous cell carcinomas (n=18) and adenosquamous carcinomas (n=7) groups (both P<0.05). Cervical squamous cell carcinomas patients with a high-expression SATB1 (n=8) had more advanced FIGO stages (P=0.015) and histologic grades (P=0.060, marginal significant) as well as a higher (P=0.069, marginal significant) incidence of lymphatic metastasis than those with a low expression of SATB1 (n=10). Conclusion:These results showed that expression of SATB1 may have an effect on the disease progression and survival outcome of cervical cancer.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Zhao L,Zheng Y,Ji Y,Zhang Xdoi
10.2147/OTT.S191414subject
Has Abstractpub_date
2019-01-30 00:00:00pages
945-951issn
1178-6930pii
ott-12-945journal_volume
12pub_type
杂志文章abstract:BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S141476
更新日期:2017-07-31 00:00:00
abstract:OBJECTIVE:To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS:A review of medical records of patients with refractor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S56361
更新日期:2014-01-29 00:00:00
abstract:BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S70654
更新日期:2014-11-27 00:00:00
abstract:Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S163883
更新日期:2018-07-10 00:00:00
abstract:Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S205017
更新日期:2019-11-07 00:00:00
abstract:Background:Melatonin (MLT), a kind of neuroendocrine active substance, has been reported to function in the treatment of tumors. However, there remain controversies about the curative effect of MLT in tumors in clinical studies. This study investigates the efficacy of MLT on tumor therapeutic strategies by meta-analysi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S174100
更新日期:2018-11-08 00:00:00
abstract:Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S217795
更新日期:2019-11-29 00:00:00
abstract::Interleukin-8 (IL-8) is a kind of chemokine that plays an important role in the development and progression of many human malignancies. Previous studies have uncovered that polymorphisms in IL-8 is associated with the risk of many cancer types, but the results were inconsistent and inconclusive. In the present study, ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S103159
更新日期:2016-06-22 00:00:00
abstract::Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL), which belong to the family of Argonaute genes/proteins, bind to piRNAs and function mainly in germ line cells, but...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S91295
更新日期:2016-01-08 00:00:00
abstract:PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S100005
更新日期:2016-03-31 00:00:00
abstract:Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S264616
更新日期:2020-11-11 00:00:00
abstract::Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S72155
更新日期:2016-02-09 00:00:00
abstract:Background and Objectives:Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation demonstrate only a median progression-free survival (PFS) of 8 to 10 months and undergo EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. For decades, bilirubin has been reported to be assoc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266477
更新日期:2020-10-29 00:00:00
abstract:Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S245663
更新日期:2020-07-27 00:00:00
abstract:Purpose:Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods:Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, m...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S243533
更新日期:2020-04-03 00:00:00
abstract::p125 is one of four subunits of human DNA polymerases - DNA Pol δ as well as one of p53 target protein encoded by POLD1. However, the function and significance of p125 and the role that p53 plays in regulating p125 expression are not fully understood in breast cancer. Tissue sections of human breast cancer obtained fr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S98713
更新日期:2016-03-10 00:00:00
abstract::Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S145105
更新日期:2017-11-08 00:00:00
abstract:Introduction:Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small sp...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S248925
更新日期:2020-08-13 00:00:00
abstract:BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S126905
更新日期:2017-03-29 00:00:00
abstract:Introduction:The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated f...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160748
更新日期:2018-04-05 00:00:00
abstract:Objective:To explore the regulatory effects of circZNF609 on proliferative and migratory capacities of gastric cancer (GC) and its underlying mechanism. Methods:Expression level of circZNF609, CDK6 and miR-483-3p in GC tissues and cells were detected qRT-PCR verification. CCK-8 and transwell assay were conducted the c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S193031
更新日期:2019-10-04 00:00:00
abstract:PURPOSE:E3 ubiquitin ligase ZNRF3 is linked to the pathogenesis of diseases and tumorigenesis. The present study aims to explore the expression of ZNRF3 and its association with prognostic survival of human colorectal carcinoma. METHODS:A follow-up survey of 168 patients with colorectal carcinoma was performed, and sp...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S108134
更新日期:2016-10-28 00:00:00
abstract::To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration-cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of respon...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S46200
更新日期:2014-04-17 00:00:00
abstract:Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S210567
更新日期:2019-08-28 00:00:00
abstract:Objective:Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA highly upregulated in liver cancer (HULC) has been identified as a key regulator in the progression of various cancers. However, the functional role and the mechanisms of HULC in regulating cervical cancer cell b...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S232914
更新日期:2020-02-05 00:00:00
abstract:BACKGROUND:The prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients wit...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S77378
更新日期:2015-04-10 00:00:00
abstract:OBJECTIVE:To study microRNA (miR)-20a expression in hepatocellular carcinoma (HCC) and its effects on the proliferation, migration, and invasion of HepG2. METHODS:The real-time polymerase chain reaction was used to detect the expression of miR-20a in HCC tissue and normal tissue, as well as in HCC cell lines and norma...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S96861
更新日期:2016-05-27 00:00:00
abstract:Background:Investigating the roles of lncRNA prostate cancer-associated transcript 6 (PCAT6) in modulating the growth and aggressiveness of non-small-cell lung carcinoma (NSCLC) cell. Method:The levels of PCAT6 in NSCLC tissues and cell lines were determined by quantitative real-time PCR assay. MTT as well as colony f...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S178597
更新日期:2018-11-01 00:00:00
abstract:Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S169002
更新日期:2018-08-20 00:00:00
abstract:BACKGROUND:Two types of epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 (ex19del and L858R) are prevalent in lung cancer patients and sensitive to targeted EGFR inhibition. A resistance mutation in exon 20 (T790M) has been found to accompany drug treatment when patients relapse. These three mut...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S84938
更新日期:2015-06-22 00:00:00