DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway.

abstract：Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...

journal_title：OncoTargets and therapy

authors： Yan Z,Yin H,Lin G

更新日期：2020-10-28 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：Introduction:The purpose of our research was to evaluate MT1JP in breast cancer. Material and Methods:For clinical purpose, tissues were collected, and a correlation analysis ofMT1JP and miRNA-214 gene expressions was conducted. Using an in vitro study, MDA-MB-231 and MCF-7 cell lines were used as research objects in ...

journal_title：OncoTargets and therapy

authors： Ouyang Q,Cui Y,Yang S,Wei W,Zhang M,Zeng J,Qu F

更新日期：2020-06-04 00:00:00

abstract：:The association between polymorphic CAG repeats in the androgen receptor gene in women and breast cancer susceptibility has been studied extensively. However, the conclusions regarding this relationship remain conflicting. The purpose of this meta-analysis was to identify whether androgen receptor CAG repeat lengths w...

journal_title：OncoTargets and therapy

authors： Mao Q,Qiu M,Dong G,Xia W,Zhang S,Xu Y,Wang J,Rong Y,Xu L,Jiang F

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that is cured in as few as 15%-40% of cases. Tremendous improvements in AML prognostication arose from a comprehensive analysis of leukemia cell genomes. Among normal karyotype AML cases, mutations in the FLT3 gene are the ones most commonly detect...

journal_title：OncoTargets and therapy

authors： Hospital MA,Green AS,Maciel TT,Moura IC,Leung AY,Bouscary D,Tamburini J

更新日期：2017-02-03 00:00:00

abstract：PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...

journal_title：OncoTargets and therapy

authors： Cruceru ML,Enciu AM,Popa AC,Albulescu R,Neagu M,Tanase CP,Constantinescu SN

更新日期：2013-11-29 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S214060.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-05-26 00:00:00

abstract：Purpose:Based on the continuous exploration of solid tumor immunotherapy, we focused on hepatocellular carcinoma with a high level of morbidity and mortality. We confirm the stability of mcDNA-based CAR T cell generating platform, and investigate the antitumor activity of CD44-CAR T cells against hepatocellular carcino...

journal_title：OncoTargets and therapy

authors： Wang H,Ye X,Ju Y,Cai Z,Wang X,Du P,Zhang M,Li Y,Cai J

更新日期：2020-05-04 00:00:00

abstract：:Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin's radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expres...

journal_title：OncoTargets and therapy

authors： Gong C,Yang Z,Zhang L,Wang Y,Gong W,Liu Y

更新日期：2017-12-21 00:00:00

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：Purpose:Here, we investigated the involvement of the miR-188-5p/inhibitor of the DNA binding 4 (ID4) axis in retinoblastoma (Rb). Patients and methods:We included 35 Rb tissues and the corresponding adjacent normal tissues. RT-qPCR, Western blot, lentivirus transfection, measurement of cell migration in vitro, and chi...

journal_title：OncoTargets and therapy

authors： Yang M,Li Y,Wei W

更新日期：2019-11-27 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：:Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...

journal_title：OncoTargets and therapy

authors： Han X,Guo X,Zhang W,Cong Q

更新日期：2019-06-20 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:We aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT) combined with chemotherapy. PATIENTS AND METHODS:From April 2006 to December 2011, ...

journal_title：OncoTargets and therapy

authors： Maklad AM,Bayoumi Y,Senosy Hassan MA,Elawadi AA,AlHussain H,Elyamany A,Aldhahri SF,Al-Qahtani KH,AlQahtani M,Tunio MA

更新日期：2016-10-25 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, which are essential d...

journal_title：OncoTargets and therapy

authors： Kim DW,Patel SP

更新日期：2014-09-19 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...

journal_title：OncoTargets and therapy

authors： Su X,Zhang J,Fu C,Xiao M,Wang C

更新日期：2020-04-21 00:00:00

abstract：:The clinicopathological and prognostic significance of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still discrepant. Systematic searches were performed in PubMed, Web of Science, Scopus, Ovid, and the Cochran Library databases for...

journal_title：OncoTargets and therapy

authors： Su X,Jiang X,Wang W,Wang H,Xu X,Lin A,Teng X,Wu H,Teng L

更新日期：2016-11-11 00:00:00

abstract：Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...

journal_title：OncoTargets and therapy

authors： Xie M,Cai L,Li J,Zhao J,Guo Y,Hou Z,Zhang X,Tian H,Li A,Miao Y

更新日期：2020-05-19 00:00:00

abstract：Purpose:Anaplastic thyroid cancer (ATC) is a kind of rare thyroid cancer with very poor prognosis. Doxorubicin has been approved in ATC treatment as a single agent, but monotherapy still shows no improvement of the total survival in advanced ATC. Lenvatinib was investigated with encouraging results in treating patients...

journal_title：OncoTargets and therapy

authors： Su X,Liu J,Zhang H,Gu Q,Zhou X,Ji M,Yao D

更新日期：2020-11-02 00:00:00

abstract：Background and aim:Standard chemotherapy has limited clinical efficacy in patients with esophageal cancer and there is a significant and unmet clinical need for effective treatment options for these patients. The aim of this study was to compare the clinical efficacy of the novel, targeted drug apatinib combined with d...

journal_title：OncoTargets and therapy

authors： Li J,Jia Y,Gao Y,Chang Z,Han H,Yan J,Qin Y

更新日期：2019-04-08 00:00:00

abstract：:Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value in clinical application. Purpose: Herein, we reported MCL-1 expression patte...

journal_title：OncoTargets and therapy

authors： Li XX,Zhou JD,Wen XM,Zhang TJ,Wu DH,Deng ZQ,Zhang ZH,Lian XY,He PF,Yao XY,Lin J,Qian J

更新日期：2019-05-01 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：Background:Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNP...

journal_title：OncoTargets and therapy

authors： Liu J,Hua RX,Cheng Y,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,Bian J,He J

更新日期：2020-01-15 00:00:00

abstract：AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...

journal_title：OncoTargets and therapy

authors： Tang D,Liu CY,Shen D,Fan S,Su X,Ye P,Gavine PR,Yin X

更新日期：2014-12-16 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S227758.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-01-29 00:00:00

abstract：Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...

journal_title：OncoTargets and therapy

authors： Zhou JH,Yao ZX,Zheng Z,Yang J,Wang R,Fu SJ,Pan XF,Liu ZH,Wu K

更新日期：2020-09-30 00:00:00

abstract：Background:Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used as effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatech...

journal_title：OncoTargets and therapy

authors： Meng J,Chang C,Chen Y,Bi F,Ji C,Liu W

更新日期：2019-07-26 00:00:00