Profile of selumetinib and its potential in the treatment of melanoma.

abstract：Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...

journal_title：OncoTargets and therapy

authors： Yan Z,Yin H,Lin G

更新日期：2020-10-28 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...

journal_title：OncoTargets and therapy

authors： Chen Q,Zhang ZH,Wang S,Lang JH

更新日期：2019-12-27 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...

journal_title：OncoTargets and therapy

authors： Zong M,Jia L,Li L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：PURPOSE:This study aims to investigate the prognostic value of pretreatment C-reactive protein/albumin ratio (CAR) in human malignancies by an updated meta-analysis. METHODS:PubMed, Web of Science, Cochrane Library and Wanfang databases were searched. Pooled hazard ratios (HRs) and odds ratios (ORs) with their corresp...

journal_title：OncoTargets and therapy

authors： Xu HJ,Ma Y,Deng F,Ju WB,Sun XY,Wang H

更新日期：2017-06-19 00:00:00

abstract：PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...

journal_title：OncoTargets and therapy

authors： Boselli C,Renzi C,Gemini A,Castellani E,Trastulli S,Desiderio J,Corsi A,Barberini F,Cirocchi R,Santoro A,Parisi A,Redler A,Noya G

更新日期：2013-01-01 00:00:00

abstract：Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...

journal_title：OncoTargets and therapy

authors： Rodrigues-Junior DM,Pelarin MFA,Nader HB,Vettore AL,Pinhal MAS

更新日期：2021-01-15 00:00:00

abstract：Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...

journal_title：OncoTargets and therapy

authors： Zhou J,Wu L,Li W,Xu X,Ju F,Yu S,Guo J,Li G,Shi J,Zhou S

更新日期：2020-08-21 00:00:00

abstract：:Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...

journal_title：OncoTargets and therapy

authors： Li X,Zhang Z,Liu J,Wang D,Wei S,Chen J

更新日期：2018-02-09 00:00:00

abstract：:Acute pancreatitis is a rare complication in postoperative colorectal cancer patients after FOLFOX6 (oxaliplatin + calcium folinate +5-FU [5-fluorouracil]) chemotherapy. In this paper, a total of 62 patients with gastrointestinal cancer were observed after the burst of acute pancreatitis. Surgery of the 62 cases of co...

journal_title：OncoTargets and therapy

authors： Ji Y,Han Z,Shao L,Li Y,Zhao L,Zhao Y

更新日期：2015-09-11 00:00:00

abstract：Purpose:Here, we investigated the involvement of the miR-188-5p/inhibitor of the DNA binding 4 (ID4) axis in retinoblastoma (Rb). Patients and methods:We included 35 Rb tissues and the corresponding adjacent normal tissues. RT-qPCR, Western blot, lentivirus transfection, measurement of cell migration in vitro, and chi...

journal_title：OncoTargets and therapy

authors： Yang M,Li Y,Wei W

更新日期：2019-11-27 00:00:00

abstract：:[This retracts the article on p. 1997 in vol. 9, PMID: 27103825.][This retracts the article on p. 841 in vol. 28.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:According to the relevant reports, TIMP-2 polymorphism might be associated with the susceptibility to gastric cancer. Owing to the inconclusive results from the published studies based on the association between TIMP-2 single nucleotide polymorphisms (SNPs) and gastric cancer susceptibility, a meta-analysis ...

journal_title：OncoTargets and therapy

authors： Yang Y,Xiong Y,Li J,Wu C,Jiang J

更新日期：2016-11-03 00:00:00

abstract：:Purpose: Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients are still comparatively low. Therefore, potential therapeutic targets are urgently needed to improve the survival of lung cancer patients. In t...

journal_title：OncoTargets and therapy

authors： Sun H,Liu K,Huang J,Sun Q,Shao C,Luo J,Xu L,Shen Y,Ren B

更新日期：2019-04-17 00:00:00

abstract：Background:The inflammatory indexes are attracting increasing attention as a prognostic predictor for colorectal cancer (CRC). However, the prognostic value of the preoperative lymphocyte-to-C-reactive protein ratio (LCR) in patients with non-metastatic CRC remains to be established. Methods:A total of 955 patients fr...

journal_title：OncoTargets and therapy

authors： Ou W,Zhou C,Zhu X,Lin L,Xu Q

更新日期：2021-01-12 00:00:00

abstract：:[This retracts the article DOI: 10.2147/OTT.S232594.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-10-07 00:00:00

abstract：:CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

journal_title：OncoTargets and therapy

authors： Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

更新日期：2020-09-22 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00

abstract：Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...

journal_title：OncoTargets and therapy

authors： Bayramov B,Gunes S,Buyukalpelli R,Aydın O,Henkel R

更新日期：2018-07-19 00:00:00

abstract：:Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...

journal_title：OncoTargets and therapy

authors： Li F,Huang Q,Gong Z,Wang H,Chen J

更新日期：2019-05-31 00:00:00

abstract：:Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...

journal_title：OncoTargets and therapy

authors： Zhao F,Ge YZ,Zhou LH,Xu LW,Xu Z,Ping WW,Wang M,Zhou CC,Wu R,Jia RP

更新日期：2017-11-22 00:00:00

abstract：Introduction:Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tum...

journal_title：OncoTargets and therapy

authors： Lu Q,Wang X,Zhu J,Fei X,Chen H,Li C

更新日期：2020-11-18 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：:[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2017-04-27 00:00:00

abstract：:Despite the prominent effects of BCR-ABL tyrosine kinase inhibitors (TKI) therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) and thus low incidence of blastic transformation, blast phase (BP)-CML remains a major therapeutic challenge in the TKI era. The "gatekeeper" mutation T315I in BCR-ABL1 kin...

journal_title：OncoTargets and therapy

authors： Zhou L,Shi H,Shi W,Yang L,Zhang Y,Xu M,Chen X,Zhu Y,Mu H,Wan X,Yang Z,Zeng Y,Liu H

更新日期：2019-12-13 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...

journal_title：OncoTargets and therapy

authors： Zhou H,Su L,Liu C,Li B,Li H,Xie Y,Sun D

更新日期：2019-09-23 00:00:00

abstract：:Recently, the human gene NOTCH1 has been found to be implicated in cancer cell metastasis and the maintenance of cancer stem cells. However, for breast cancer in particular, an association between NOTCH1 levels and metastasis has not been determined. In this study, we investigated the expression status and correlation...

journal_title：OncoTargets and therapy

authors： Zhong Y,Shen S,Zhou Y,Mao F,Lin Y,Guan J,Xu Y,Zhang S,Liu X,Sun Q

更新日期：2016-11-07 00:00:00

abstract：Background:Mounting evidences reveal that circular RNAs (circRNAs) are critical to regulate biological behavior and process of tumor. Our objective is to explore the role of circRNA-PTN (circPTN) and explain the exact mechanism in hepatocellular carcinoma (HCC). Methods:Real-time polymerase chain reaction assay was us...

journal_title：OncoTargets and therapy

authors： Jia B,Yin X,Wang Y,Qian J,He Y,Yang C,Yu G,Guo B,Meng X

更新日期：2020-05-29 00:00:00