Identification of hub miRNA biomarkers for bladder cancer by weighted gene coexpression network analysis.

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...

journal_title：OncoTargets and therapy

authors： Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR

更新日期：2016-10-13 00:00:00

abstract：Background:Intra-abdominal desmoplastic small round cell tumor (IADSRCT) is a highly invasive malignant tumor that is rare in clinical practice. Anlotinib is a multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1-3, fibroblast growth factor receptor (FGFR) ...

journal_title：OncoTargets and therapy

authors： Chen HM,Feng G

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...

journal_title：OncoTargets and therapy

authors： Wang N,Wang Q,Shen D,Sun X,Cao X,Wu D

更新日期：2016-04-06 00:00:00

abstract：:Trastuzumab is a monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). HER2 is amplified or overexpressed in about 15% of breast cancers and is associated with aggressive disease. Clinical benefits of trastuzumab have been established in the treatment of both early and metastatic HE...

journal_title：OncoTargets and therapy

authors： Hamizi S,Freyer G,Bakrin N,Henin E,Mohtaram A,Le Saux O,Falandry C

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To evaluate whether the addition of two biological markers (MYC and BCL-2 protein overexpression) improves the stratification of high-risk patients with diffuse large B-cell lymphoma (DLBCL). METHOD:Seven risk factors were identified at diagnosis, and a maximum of 7 points were assigned to each patient. The pa...

journal_title：OncoTargets and therapy

authors： Wang J,Zhou M,Xu JY,Chen B,Ouyang J

更新日期：2015-09-18 00:00:00

abstract：:The epidermal growth-factor receptor (EGFR) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. This makes EGFR an attractive therapeutic target in this disease. A number of strategies to block EGF...

journal_title：OncoTargets and therapy

authors： Hirte HW

更新日期：2013-04-18 00:00:00

abstract：OBJECTIVE:To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS:A review of medical records of patients with refractor...

journal_title：OncoTargets and therapy

authors： Feng F,Hu H,Wu L,Ren T,Wan X,Xiang Y

更新日期：2014-01-29 00:00:00

abstract：Introduction:Melanoma has been reported as the most common malignancy in skin cancer. The small nucleolar RNA host gene 5 (SNHG5), an lncRNA, has been proven as a vital regulator in several types of carcinoma. This study was designed to investigate the detailed roles and possible mechanisms of SNHG5 in melanoma progres...

journal_title：OncoTargets and therapy

authors： Gao J,Zeng K,Liu Y,Gao L,Liu L

更新日期：2018-12-24 00:00:00

abstract：Objective:Growing epidemiological evidence supports that coagulation cascades and cancer-associated inflammation are associated with recurrence and survival of epithelial ovarian cancer (EOC). This study aimed to assess the clinical significance of the combination of plasm fibrinogen and neutrophil lymphocyte ratio (F-...

journal_title：OncoTargets and therapy

authors： Yang J,Ma J,Cheng S,Wang Y

更新日期：2020-07-27 00:00:00

abstract：Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...

journal_title：OncoTargets and therapy

authors： Zhou H,Su L,Liu C,Li B,Li H,Xie Y,Sun D

更新日期：2019-09-23 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the patterns of expression of epithelial-mesenchymal transition (EMT)-related proteins in intrahepatic cholangiocarcinoma. The clinicopathological and prognostic value of these markers was also evaluated. METHODS:We detected the expression status of three EMT-related pro...

journal_title：OncoTargets and therapy

authors： Yao X,Wang X,Wang Z,Dai L,Zhang G,Yan Q,Zhou W

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Subsets of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon subtypes. We evaluated the efficacy of first-generation EGFR-tyrosine kinase inhibitors (TKIs; erlotinib, gefitinib, and icotinib) in patients with non-small-cell lung cancer carrying insertions ...

journal_title：OncoTargets and therapy

authors： Chen D,Song Z,Cheng G

更新日期：2016-07-08 00:00:00

abstract：Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...

journal_title：OncoTargets and therapy

authors： Rodrigues-Junior DM,Pelarin MFA,Nader HB,Vettore AL,Pinhal MAS

更新日期：2021-01-15 00:00:00

abstract：PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...

journal_title：OncoTargets and therapy

authors： Chen J,Li H,Pang R,Huang J

更新日期：2017-04-06 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：Purposes:The main aim of the study was to investigate the dosimetric difference between acuros XB algorithm (AXB), anisotropic analytic algorithm (AAA), and pencil beam convolution (PBC) algorithm in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC). Patients and Methods:Thirty-eig...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang D,Su H,Dai Z,Dai J,Liu H,Xie C,Yu H

更新日期：2019-08-12 00:00:00

abstract：Background:Although there have been great advances in mechanisms and therapeutic methods of prostate cancer, the mortality rate of prostate cancer remains high. The castration-resistant prostate cancer (CRPC), which develops from hormone-sensitive prostate cancer, foreshadows a more dismal outcome. Concomitant with the...

journal_title：OncoTargets and therapy

authors： Wang K,Ruan H,Xu T,Liu L,Liu D,Yang H,Zhang X,Chen K

更新日期：2018-05-28 00:00:00

abstract：BACKGROUND:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) is identified to be overexpressed in several cancers. However, the role of MALAT-1 in chondrosarcoma is poorly understood. METHODS:The expression of MALAT-1 and Notch-1 signaling pathway was detected in chondrosarcoma tissues and chondrosarcom...

journal_title：OncoTargets and therapy

authors： Xu F,Zhang ZQ,Fang YC,Li XL,Sun Y,Xiong CZ,Yan LQ,Wang Q

更新日期：2016-04-13 00:00:00

abstract：Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...

journal_title：OncoTargets and therapy

authors： Liang C,Yue C,Liang C,Ge H,Wei Z,Li G,Wu J,Huang H,Guo J

更新日期：2019-10-30 00:00:00

abstract：Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...

journal_title：OncoTargets and therapy

authors： He Y,Wang Y,Zhao S,Zhao C,Zhou C,Hirsch FR

更新日期：2018-08-13 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METH...

journal_title：OncoTargets and therapy

authors： Dequanter D,Shahla M,Aubert C,Deniz Y,Lothaire P

更新日期：2015-08-26 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...

journal_title：OncoTargets and therapy

authors： Tang D,Liu CY,Shen D,Fan S,Su X,Ye P,Gavine PR,Yin X

更新日期：2014-12-16 00:00:00

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:Forkhead box Q1 (FOXQ1, also known as HFH1), a member of the forkhead transcription factor family, has been demonstrated to be overexpressed in multiple tumors and is thought to be an indicator of poor clinical outcomes. METHODS:A meta-analysis using qualified relevant literature was performed to evaluate t...

journal_title：OncoTargets and therapy

authors： Cui X,Zhang J,Lv J,Yan Y,Liu X,Wang J,Lv Y,Zhang J

更新日期：2017-03-23 00:00:00

abstract：:This report describes a patient with intravascular large B-cell lymphoma (IVLBCL) with central nervous system involvement at the time of diagnosis who achieved complete remission for over 5 years in response to therapy. The patient, a 71 year-old woman, was previously healthy with the exception of taking verapamil for...

journal_title：OncoTargets and therapy

authors： Sawada T,Omuro Y,Kobayashi T,Hishima T,Koizumi F,Kanemasa Y,Shimoyama T,Sasaki E,Maeda Y

更新日期：2014-11-18 00:00:00

abstract：Background:Paclitaxel is widely used in the treatment of cancer and has a good effect in the treatment of non-small cell lung cancer. The combination of TMT proteomics and bioinformatics is used to systematically analyze the molecular mechanism of paclitaxel in the treatment of lung adenocarcinoma A549 cell, which is h...

journal_title：OncoTargets and therapy

authors： Zheng W,Xu S

更新日期：2020-10-13 00:00:00