Dosimetric comparison of different algorithms in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC).

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：Purpose:Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellul...

journal_title：OncoTargets and therapy

authors： Shi S,Zheng G,Yang C,Chen X,Yan Q,Jiang F,Jiang X,Xin Y,Jiang G

更新日期：2019-12-31 00:00:00

abstract：Purpose:To evaluate the association between tertiary Gleason pattern 5 (TGP5) and biochemical recurrence (BCR) in patients with prostate cancer (PCa) with a Gleason score (GS) of 7 after radical prostatectomy (RP). Patients and methods:This retrospective study identified 350 patients who received RP and were graded as...

journal_title：OncoTargets and therapy

authors： Li J,Guo Y,Qiu S,He M,Jin K,Zheng X,Tu X,Liao X,Yang L,Wei Q

更新日期：2019-09-02 00:00:00

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Tumor cells before and after epidermal growth-factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) therapy might display different characteristics. The aim of this study was to evaluate the influence of prior EGFR TKI therapy on the efficacy of subsequent pemetrexed plus platinum (PP) in advanced chemonaïv...

journal_title：OncoTargets and therapy

authors： Tseng JS,Yang TY,Chen KC,Hsu KH,Yu CJ,Liao WY,Tsai CR,Tsai MH,Yu SL,Su KY,Chen JJ,Chen HY,Chang GC

更新日期：2014-05-23 00:00:00

abstract：:This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to t...

journal_title：OncoTargets and therapy

authors： Zhu X,Luo W,Liang W,Tang F,Bei C,Ren Y,Qin L,Tan C,Zhang Y,Tan S

更新日期：2016-12-12 00:00:00

abstract：:Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin ex...

journal_title：OncoTargets and therapy

authors： Cheung CH,Huang CC,Tsai FY,Lee JY,Cheng SM,Chang YC,Huang YC,Chen SH,Chang JY

更新日期：2013-10-16 00:00:00

abstract：Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...

journal_title：OncoTargets and therapy

authors： Gao S,Song D,Liu Y,Yan H,Chen X

更新日期：2020-07-01 00:00:00

abstract：Objective:We aimed to determine the safety and efficacy of irreversible electroporation (IRE) combined with chemotherapy for unresectable pancreatic carcinoma (stage III/IV). Methods:We prospectively enrolled 54 patients (30 men; median age 61.0 years; range 41-73 years) undergoing IRE with or without chemotherapy for...

journal_title：OncoTargets and therapy

authors： Liu S,Qin Z,Xu J,Zeng J,Chen J,Niu L,Xu M

更新日期：2019-02-18 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast ...

journal_title：OncoTargets and therapy

authors： Ludmir EB,Gutschenritter T,Pinnix CC,Gunther JR,Nastoupil LJ,Khoury JD,Medeiros LJ,Dabaja BS,Milgrom SA

更新日期：2018-12-10 00:00:00

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...

journal_title：OncoTargets and therapy

authors： Han M,Chen L,Wang Y

更新日期：2018-09-28 00:00:00

abstract：Background:Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance. Materials and methods:We explored the pub...

journal_title：OncoTargets and therapy

authors： Wang W,Han T,Tong W,Zhao J,Qiu X

更新日期：2018-09-26 00:00:00

abstract：Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...

journal_title：OncoTargets and therapy

authors： Luo Y,Yu P,Zhao J,Guo Q,Fan B,Diao Y,Jin Y,Wu J,Zhang C

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：Background and aim:Ewing sarcoma (ES) is an aggressive neoplasm predominantly occurring in adolescents and has a poor prognosis when metastasized. In the current study, we were aiming to investigate the function of TRIM3 in autophagy in ES cells. Methods:The expression of TRIM3 in Ewing sarcoma tissues and normal tiss...

journal_title：OncoTargets and therapy

authors： Lu Q,Zhang Y,Ma L,Li D,Li M,Liu P,Li J

更新日期：2019-12-30 00:00:00

abstract：Introduction:Cyclophosphamide, which is widely used to treat malignant disease, causes ovarian follicular atresia, which leads to premature ovarian insufficiency. The present study evaluated the protective effect of testosterone in preventing the decline in the ovarian reserve during cyclophosphamide treatment. Method...

journal_title：OncoTargets and therapy

authors： Yoo M,Tanaka T,Konishi H,Tanabe A,Taniguchi K,Komura K,Hayashi M,Ohmichi M

更新日期：2020-04-08 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...

journal_title：OncoTargets and therapy

authors： Zhao X,Hu GF,Shi YF,Xu W

更新日期：2019-12-24 00:00:00

abstract：OBJECTIVES:PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. PATIENTS AND METHODS:We performed immunohistochemical stain...

journal_title：OncoTargets and therapy

authors： Chang H,Kim JS,Choi YJ,Cho JG,Woo JS,Kim A,Kim JS,Kang EJ

更新日期：2017-06-13 00:00:00

abstract：Purpose:miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated. Methods:Bioinformatics was used to analyze the target genes of miR-497-5p. qRT-PCR and Western blot were used to analyze mRNA and protein expression, respectively. Dual-luciferase reporter ass...

journal_title：OncoTargets and therapy

authors： Chen Y,Du J,Wang Y,Shi H,Jiang Q,Wang Y,Zhang H,Wei Y,Xue W,Pu Z,Gao Y,Li D,Feng Y,Yan J,Zhang J

更新日期：2019-12-02 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：Background:It has been reported that ribophorin II (RPN2) expression is increased in many cancers, but the role of RPN2 in nasopharyngeal carcinoma (NPC) remains unclear. Patients and methods:This study found that the expression of RPN2 is increased dramatically in NPC tissues of patients compared with that in the adj...

journal_title：OncoTargets and therapy

authors： Hong F,Li Y,Ni H,Li J

更新日期：2018-06-15 00:00:00

abstract：Background:Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNP...

journal_title：OncoTargets and therapy

authors： Liu J,Hua RX,Cheng Y,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,Bian J,He J

更新日期：2020-01-15 00:00:00

abstract：OBJECTIVES:MicroRNA (miRNA)-related single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. A miR-SNP of rs11077 located in the 3' untranslated region (3' UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced n...

journal_title：OncoTargets and therapy

authors： Ding C,Li C,Wang H,Li B,Guo Z

更新日期：2013-07-11 00:00:00

abstract：Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...

journal_title：OncoTargets and therapy

authors： Wang X,Lu Q,Fei X,Zhao Y,Shi B,Li C,Chen H

更新日期：2020-02-12 00:00:00

abstract：Background/Aims:The effects of lncRNA-NORAD/mir-520a-3p on proliferation and invasion of non-small cell lung cancer (NSCLC) were studied, and its potential molecular mechanism was discussed. Methods:qRT-PCR was used to detect the expression of lncRNA NORAD and miR-520a-3p in non-small cell lung cancer tissues and cell...

journal_title：OncoTargets and therapy

authors： Wan Y,Yao Z,Chen W,Li D

更新日期：2020-02-19 00:00:00

abstract：Background:Intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two of the main treatment techniques for cervical cancer. Whether either technique significantly reduces irradiated volumes of organs at risk (OARs) remains controversial. The aim of this study was to explore which o...

journal_title：OncoTargets and therapy

authors： Bai W,Kou C,Yu W,Li Y,Hua W,Yu L,Wang J

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...

journal_title：OncoTargets and therapy

authors： Hu QC,Mei X,Feng Y,Ma JL,Yang ZZ,Shao ZM,Yu XL,Guo XM

更新日期：2015-11-04 00:00:00

abstract：Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...

journal_title：OncoTargets and therapy

authors： Liu X,Song Y,Liang P,Su T,Zhang H,Zhao X,Yuan Z,Wang P

更新日期：2017-11-06 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00