Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms.

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...

journal_title：OncoTargets and therapy

authors： Yue S,Shi H,Han J,Zhang T,Zhu W,Zhang D

更新日期：2016-10-11 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S227758.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-01-29 00:00:00

abstract：Background:The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progressio...

journal_title：OncoTargets and therapy

authors： Jin Y,Xie H,Duan L,Zhao D,Ding J,Jiang G

更新日期：2019-10-31 00:00:00

abstract：:p125 is one of four subunits of human DNA polymerases - DNA Pol δ as well as one of p53 target protein encoded by POLD1. However, the function and significance of p125 and the role that p53 plays in regulating p125 expression are not fully understood in breast cancer. Tissue sections of human breast cancer obtained fr...

journal_title：OncoTargets and therapy

authors： Zhang L,Yang W,Zhu X,Wei C

更新日期：2016-03-10 00:00:00

abstract：:Pleiotropy in biological systems and their targeting allows many pharmaceuticals to be used for multiple therapeutic purposes. Fully exploiting the therapeutic properties of drugs that are already marketed would be highly advantageous. This is especially the case in the field of oncology, where the ineffectiveness of ...

journal_title：OncoTargets and therapy

authors： Papanagnou P,Papadopoulos GE,Stivarou T,Pappas A

更新日期：2018-12-31 00:00:00

abstract：:During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcom...

journal_title：OncoTargets and therapy

authors： Cai J,Wang D,Zhang G,Guo X

更新日期：2019-10-15 00:00:00

abstract：Background and aim:Standard chemotherapy has limited clinical efficacy in patients with esophageal cancer and there is a significant and unmet clinical need for effective treatment options for these patients. The aim of this study was to compare the clinical efficacy of the novel, targeted drug apatinib combined with d...

journal_title：OncoTargets and therapy

authors： Li J,Jia Y,Gao Y,Chang Z,Han H,Yan J,Qin Y

更新日期：2019-04-08 00:00:00

abstract：BACKGROUND:Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain. PATIENTS AND METHODS:In this retrosp...

journal_title：OncoTargets and therapy

authors： Teng Y,Wang Z,Ma L,Zhang L,Guo Y,Gu M,Wang Z,Wang Y,Yue W

更新日期：2016-07-07 00:00:00

abstract：:Advanced gastric cancer (AGC) is difficult to treat with poor prognosis. Despite various possible treatments, the median survival time of such patients remains unsatisfactory. Therefore, new therapeutic approaches or combinations need to be further explored. We herein reported a case of a 54-year-old male patient who ...

journal_title：OncoTargets and therapy

authors： Yu S,Cai L,Lin F,Wu X,Zhang C,Liu X,Li W

更新日期：2019-09-19 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：Purpose:Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging ar...

journal_title：OncoTargets and therapy

authors： Boogerd LS,van der Valk MJ,Boonstra MC,Prevoo HA,Hilling DE,van de Velde CJ,Sier CF,Fariña Sarasqueta A,Vahrmeijer AL

更新日期：2018-03-23 00:00:00

abstract：:Low-grade fetal lung adenocarcinoma (L-FLAC) is an exceptionally rare pulmonary tumor, presenting with unclear histological and molecular features. In particular, the potential driver genes of L-FLAC remain elusive. To date, only five reports have documented genetic aberrations in L-FLAC. In the current study, we desc...

journal_title：OncoTargets and therapy

authors： Liu S,Wang J,Luo X,Li X,Miao Y,Wang L,Li Q,Qiu X,Wang EH

更新日期：2020-07-07 00:00:00

abstract：:The epidermal growth-factor receptor (EGFR) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. This makes EGFR an attractive therapeutic target in this disease. A number of strategies to block EGF...

journal_title：OncoTargets and therapy

authors： Hirte HW

更新日期：2013-04-18 00:00:00

abstract：:Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...

journal_title：OncoTargets and therapy

authors： Wang G,Jing Y,Cao L,Gong C,Gong Z,Cao X

更新日期：2016-12-20 00:00:00

abstract：:Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes with different biology showing different sensitivity to therapeutic agents. For decades, the standard first-line systemic treatment o...

journal_title：OncoTargets and therapy

authors： Recine F,Bongiovanni A,Riva N,Fausti V,De Vita A,Mercatali L,Liverani C,Miserocchi G,Amadori D,Ibrahim T

更新日期：2017-02-23 00:00:00

abstract：AIM:This study was designed to investigate the predictive and prognostic values of serum vascular endothelial growth factor (VEGF) level in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. METHODS:Patients' peripheral blood samples were collected prior to chemotherapy and after 1 w...

journal_title：OncoTargets and therapy

authors： Zang J,Hu Y,Xu X,Ni J,Yan D,Liu S,He J,Xue J,Wu J,Feng J

更新日期：2017-01-18 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S196910.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2019-09-19 00:00:00

abstract：BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...

journal_title：OncoTargets and therapy

authors： Leal P,Garcia P,Sandoval A,Buchegger K,Weber H,Tapia O,Roa JC

更新日期：2013-10-03 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...

journal_title：OncoTargets and therapy

authors： Zong M,Jia L,Li L

更新日期：2013-01-01 00:00:00

abstract：Purpose:Anaplastic thyroid cancer (ATC) is a kind of rare thyroid cancer with very poor prognosis. Doxorubicin has been approved in ATC treatment as a single agent, but monotherapy still shows no improvement of the total survival in advanced ATC. Lenvatinib was investigated with encouraging results in treating patients...

journal_title：OncoTargets and therapy

authors： Su X,Liu J,Zhang H,Gu Q,Zhou X,Ji M,Yao D

更新日期：2020-11-02 00:00:00

abstract：:Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...

journal_title：OncoTargets and therapy

authors： Baldo P,Cecco S

更新日期：2017-11-08 00:00:00

abstract：Purpose:To evaluate the capability of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patien...

journal_title：OncoTargets and therapy

authors： Zhu W,Zhang Y,Kong L,Huang Y,Zheng J,Wang R,Li M,Yu J

更新日期：2018-07-25 00:00:00

abstract：:Glioblastoma is the most aggressive type of brain tumor with a very poor prognosis. Therefore, it is always of great importance to explore and develop new potential treatment for glioblastoma. Quercetin, a flavonoid present in a variety of human foods, has been shown to inhibit various tumor cell proliferation. In thi...

journal_title：OncoTargets and therapy

authors： Liu Y,Tang ZG,Yang JQ,Zhou Y,Meng LH,Wang H,Li CL

更新日期：2017-08-11 00:00:00

abstract：PURPOSE:Although numerous studies have demonstrated associations between the preoperative neutrophil-to-lymphocyte ratio (NLR) and long-term outcomes in patients with non-small cell lung cancer (NSCLC), the prognostic significance of postoperative NLR and change in NLR (ΔNLR) is unknown for patients who underwent compl...

journal_title：OncoTargets and therapy

authors： Jin F,Han A,Shi F,Kong L,Yu J

更新日期：2016-10-21 00:00:00

abstract：:The fusion of echinoderm microtubule-associated protein-like 4 with anaplastic lymphoma kinase (ALK) was identified as a transforming gene for lung cancer in 2007. This genetic rearrangement accounts for 2%-5% of non-small-cell lung cancer (NSCLC) cases, occurring predominantly in younger individuals with adenocarcino...

journal_title：OncoTargets and therapy

authors： Iwama E,Okamoto I,Harada T,Takayama K,Nakanishi Y

更新日期：2014-03-05 00:00:00