Abstract:
:Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes with different biology showing different sensitivity to therapeutic agents. For decades, the standard first-line systemic treatment of metastatic STS has comprised anthracycline based-chemotherapy. Second-line therapy options include agents such as ifosfamide, gemcitabine, and pazopanib, but the optimal sequential therapy for the management of metastatic disease has yet to be defined. Trabectedin is one of the new molecules approved for patients in progression after first-line chemotherapy with anthracyclines or for those unfit for these agents. The compound is characterized by multiple potential mechanisms of action combining cytotoxic, targeted, and immunological effects. This article takes an in-depth look at the role of trabectedin in the management of metastatic STS, including L-sarcoma and non-L-sarcoma.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Recine F,Bongiovanni A,Riva N,Fausti V,De Vita A,Mercatali L,Liverani C,Miserocchi G,Amadori D,Ibrahim Tdoi
10.2147/OTT.S127955subject
Has Abstractpub_date
2017-02-23 00:00:00pages
1155-1164issn
1178-6930pii
ott-10-1155journal_volume
10pub_type
杂志文章,评审abstract:Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247491
更新日期:2020-05-19 00:00:00
abstract::Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S227156
更新日期:2019-12-27 00:00:00
abstract::Interleukin-8 (IL-8) is a kind of chemokine that plays an important role in the development and progression of many human malignancies. Previous studies have uncovered that polymorphisms in IL-8 is associated with the risk of many cancer types, but the results were inconsistent and inconclusive. In the present study, ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S103159
更新日期:2016-06-22 00:00:00
abstract:Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S139243
更新日期:2017-11-15 00:00:00
abstract:Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S254167
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVE:To evaluate efficacy and safety of nimotuzumab combined with chemotherapy and radiotherapy in women with locally advanced cervical cancer. MATERIALS AND METHODS:Women with locally advanced cervical cancer (stage IIB, III, or IVA) who experienced relapse after first-line chemoradiotherapy and one or more line...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S133756
更新日期:2017-08-17 00:00:00
abstract:Background:A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160428
更新日期:2018-06-06 00:00:00
abstract:Background:LncRNA cancer susceptibility candidate 15 (CASC15) has been demonstrated to act as an oncogene in different cancers; however, its role in ovarian cancer remains elusive. Methods:Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA CASC15. Kaplan-Meier survival analysis was ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219900
更新日期:2019-10-23 00:00:00
abstract:INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S104182
更新日期:2016-07-13 00:00:00
abstract::This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,收录出版
doi:10.2147/OTT.S124118
更新日期:2016-12-12 00:00:00
abstract:Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S154589
更新日期:2018-01-12 00:00:00
abstract::Pleiotropy in biological systems and their targeting allows many pharmaceuticals to be used for multiple therapeutic purposes. Fully exploiting the therapeutic properties of drugs that are already marketed would be highly advantageous. This is especially the case in the field of oncology, where the ineffectiveness of ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S182685
更新日期:2018-12-31 00:00:00
abstract:Background:Circular RNAs (circRNAs) are a special class of noncoding RNAs that are involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of circRNAs in cancer, especially breast cancer (BC), are poorly understood. Materials and Methods:The expression levels of circRNA 0001073 (circ-1073)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S248822
更新日期:2020-06-29 00:00:00
abstract::Background: Previous studies have reported that the albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker-based index, is associated with clinical outcome in several cancers. However, data relating to lung cancer are rare. This study was performed to clarify the clinical significance of AAPR in patient...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S203321
更新日期:2019-07-02 00:00:00
abstract:Background:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and exhibit a high frequency of oncogenic KIT or PDGFRA mutations. Tyrosine kinase inhibitors (TKIs) have been mainly used in the treatment of GISTs bearing KIT/PDGFRA mutations. However, other mutation profiles have been found to...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S155214
更新日期:2018-04-20 00:00:00
abstract:OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95806
更新日期:2016-02-16 00:00:00
abstract::Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S226735
更新日期:2019-11-11 00:00:00
abstract::Purpose: LncRNA MIR100HG promotes several types of malignancies, while its involvement in other human diseases is unknown. Patients and methods: Our study included 70 patients with LSCC who were diagnosed and treated in the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and T...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S202528
更新日期:2019-04-17 00:00:00
abstract:BACKGROUND:According to the relevant reports, TIMP-2 polymorphism might be associated with the susceptibility to gastric cancer. Owing to the inconclusive results from the published studies based on the association between TIMP-2 single nucleotide polymorphisms (SNPs) and gastric cancer susceptibility, a meta-analysis ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S114113
更新日期:2016-11-03 00:00:00
abstract::Recently, the human gene NOTCH1 has been found to be implicated in cancer cell metastasis and the maintenance of cancer stem cells. However, for breast cancer in particular, an association between NOTCH1 levels and metastasis has not been determined. In this study, we investigated the expression status and correlation...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S109606
更新日期:2016-11-07 00:00:00
abstract:Purpose:This study aimed to explore significant genes and pathways involved in the pathogenesis of supratentorial primitive neuroectodermal tumor (sPNET). Materials and methods:Gene expression profile of GSE14295 was downloaded from publicly available Gene Expression Omnibus (GEO) database. Differentially expressed ge...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S148776
更新日期:2018-04-04 00:00:00
abstract::CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S249822
更新日期:2020-09-22 00:00:00
abstract:Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S252043
更新日期:2020-07-07 00:00:00
abstract::Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S99826
更新日期:2016-10-31 00:00:00
abstract::Normal astrocytes are more resistant to radiation than glioma cells. Radiation-resistant glioma cells and normal astrocytes usuallly share similar mechanisms of radioresistance. Investigation of the underlying mechanisms of differential radiation response between normal astrocytes and glioma cells is thus significant ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S144002
更新日期:2017-12-04 00:00:00
abstract::Primary urethral non-Hodgkin's lymphoma (NHL) is uncommon. This case study reports the case of a 52-year-old woman with a light red mass at the urethral orifice. Her clinical manifestations included frequent urination, urgency, dysuria, and occasionally blood in urine. The tumor was surgically removed, and the patholo...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S283704
更新日期:2020-12-21 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S214060.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S258499
更新日期:2020-05-26 00:00:00
abstract:Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S251508
更新日期:2020-09-24 00:00:00
abstract::This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic castration-resistant prostate cancer (CRPC). RNA was analyzed in blood from six CRPC patients by whole-transcriptome sequencing (total RNA-sequencing) before and after docetaxel ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86637
更新日期:2015-07-30 00:00:00
abstract:AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S70922
更新日期:2014-12-16 00:00:00