A current perspective on stereotactic body radiation therapy for pancreatic cancer.

abstract：Introduction:The purpose of our research was to evaluate MT1JP in breast cancer. Material and Methods:For clinical purpose, tissues were collected, and a correlation analysis ofMT1JP and miRNA-214 gene expressions was conducted. Using an in vitro study, MDA-MB-231 and MCF-7 cell lines were used as research objects in ...

journal_title：OncoTargets and therapy

authors： Ouyang Q,Cui Y,Yang S,Wei W,Zhang M,Zeng J,Qu F

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:Lapatinib is a dual epidermal growth factor receptor (EGFR) and HER2 inhibitor. Overexpression of these receptors is frequently observed in head and neck squamous cell carcinoma (HNSCC). As growing proportion of HNSCC is characterized by human papillomavirus (HPV) infection, we aimed at evaluating the effica...

journal_title：OncoTargets and therapy

authors： Fumagalli I,Dugue D,Bibault JE,Clémenson C,Vozenin MC,Mondini M,Deutsch E

更新日期：2015-02-02 00:00:00

abstract：:Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...

journal_title：OncoTargets and therapy

authors： Wang G,Jing Y,Cao L,Gong C,Gong Z,Cao X

更新日期：2016-12-20 00:00:00

abstract：Introduction:Systemic inflammation is associated with prognosis in solid tumors. The neutrophil-to-lymphocyte ratio (NLR) is a marker for the general immune response to various stress stimuli. Studies have shown correlation of NLR to outcomes in immune checkpoint blockade, peripheral neutrophil count to intratumor neut...

journal_title：OncoTargets and therapy

authors： Sacdalan DB,Lucero JA,Sacdalan DL

更新日期：2018-02-23 00:00:00

abstract：:Background: CD19-directed chimeric antigen receptor (CAR) T cells have substantial benefit in the treatment of patients with B-cell malignancies. However, despite encouraging therapeutic efficiency, there is limited overall response rate when anti-CD19 CAR-T cells are used to treat patients with relapsed and refractor...

journal_title：OncoTargets and therapy

authors： Li S,Xue L,Wang M,Qiang P,Xu H,Zhang X,Kang W,You F,Xu H,Wang Y,Liu X,Yang L,Wang X

更新日期：2019-07-12 00:00:00

abstract：:Pleiotropy in biological systems and their targeting allows many pharmaceuticals to be used for multiple therapeutic purposes. Fully exploiting the therapeutic properties of drugs that are already marketed would be highly advantageous. This is especially the case in the field of oncology, where the ineffectiveness of ...

journal_title：OncoTargets and therapy

authors： Papanagnou P,Papadopoulos GE,Stivarou T,Pappas A

更新日期：2018-12-31 00:00:00

abstract：:Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic the...

journal_title：OncoTargets and therapy

authors： Tysome JR,Lemoine NR,Wang Y

更新日期：2013-07-31 00:00:00

abstract：Background:Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therapy is usually at high intensity, and contact or even invasive electrodes are typically used, which may cause unwanted side effects. ...

journal_title：OncoTargets and therapy

authors： Lu CH,Lin SH,Hsieh CH,Chen WT,Chao CY

更新日期：2018-08-10 00:00:00

abstract：BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...

journal_title：OncoTargets and therapy

authors： Fu Y,Cao F

更新日期：2015-12-17 00:00:00

abstract：:Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics ana...

journal_title：OncoTargets and therapy

authors： Chen YH,Lin TT,Wu YP,Li XD,Chen SH,Xue XY,Wei Y,Zheng QS,Huang JB,Xu N

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...

journal_title：OncoTargets and therapy

authors： Xiong Y,Lai X,Xiang W,Zhou J,Han J,Li H,Deng H,Liu L,Peng J,Chen L

更新日期：2020-09-17 00:00:00

abstract：Background:The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer. Methods:The ...

journal_title：OncoTargets and therapy

authors： Xue F,Li QR,Xu YH,Zhou HB

更新日期：2019-11-05 00:00:00

abstract：:Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...

journal_title：OncoTargets and therapy

authors： Zhou F,Chen X,Fan S,Tai S,Jiang C,Zhang Y,Hao Z,Zhou J,Shi H,Zhang L,Liang C

更新日期：2015-04-10 00:00:00

abstract：:In the last decade, the advent of biological targeted therapies has revolutionized the management of several types of cancer, especially in the realm of hematologic malignancies. One of these pathways, and the center of this review, is the phosphatidylinositol-3-kinase (PI3K) pathway. The PI3K pathway seems to play an...

journal_title：OncoTargets and therapy

authors： Castillo JJ,Iyengar M,Kuritzky B,Bishop KD

更新日期：2014-02-21 00:00:00

abstract：PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...

journal_title：OncoTargets and therapy

authors： Boselli C,Renzi C,Gemini A,Castellani E,Trastulli S,Desiderio J,Corsi A,Barberini F,Cirocchi R,Santoro A,Parisi A,Redler A,Noya G

更新日期：2013-01-01 00:00:00

abstract：:This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

journal_title：OncoTargets and therapy

authors： Liu P,Zhu Y,Liu L

更新日期：2015-06-04 00:00:00

abstract：Background:Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer...

journal_title：OncoTargets and therapy

authors： Zou YF,Rong YM,Chen ZX,Shen ZH,Chen X,Tan YX,Weng JR,Huang XM,Lin XT

更新日期：2020-08-26 00:00:00

abstract：:ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...

journal_title：OncoTargets and therapy

authors： Li L,Sun F,Chen X,Zhang M

更新日期：2018-02-14 00:00:00

abstract：BACKGROUND:Current cancer treatments have unexpected side effects of which the death of normal cells is one. In some cancers, iron nanoparticles (NPs) can be subjected to diagnosis and passive targeting treatment. Cold atmospheric plasma (CAP) has a proven induction of selective cell death ability. In this study, we ha...

journal_title：OncoTargets and therapy

authors： Jalili A,Irani S,Mirfakhraie R

更新日期：2016-09-28 00:00:00

abstract：:Despite advances in the treatment of multiple myeloma, it remains an incurable disease, with relapses and resistances frequently observed. Recently, immunotherapies, in particular, monoclonal antibodies, have become important treatment options in anticancer therapies. Elotuzumab is a humanized monoclonal antibody to s...

journal_title：OncoTargets and therapy

authors： Weisel K

更新日期：2016-10-05 00:00:00

abstract：:Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV...

journal_title：OncoTargets and therapy

authors： Guo L,Hua K

更新日期：2020-08-12 00:00:00

abstract：:Glioma is the most common and aggressive human primary tumor in the central nervous system. Despite present clinical advancements, median survival time remains poor in this malignant tumor. Serpin peptidase inhibitor, clade A member 3 (SERPINA3), is a member of the serpin superfamily of protease inhibitors. Its aberra...

journal_title：OncoTargets and therapy

authors： Luo D,Chen W,Tian Y,Li J,Xu X,Chen C,Li F

更新日期：2017-04-18 00:00:00

abstract：Purpose:Bulky non-small cell lung cancer (NSCLC) is difficult to achieve effective local control by conventionally fractionated radiotherapy (CRT). The present work aims to evaluate the safety and efficacy of partial stereotactic ablative boost radiotherapy (P-SABR) in bulky NSCLC. Patients and methods:From December 2...

journal_title：OncoTargets and therapy

authors： Bai Y,Gao XS,Qin SB,Chen JY,Su MM,Liu Q,Qin XB,Ma MW,Zhao B,Gu XB,Xie M,Cui M,Qi X,Li XY

更新日期：2018-05-08 00:00:00

abstract：AIM:To retrospectively evaluate the safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in the treatment of patients with advanced intrahepatic cholangiocarcinoma (ICC). METHODS:All patients treated with ultrasound-guided perc...

journal_title：OncoTargets and therapy

authors： Yang GW,Zhao Q,Qian S,Zhu L,Qu XD,Zhang W,Yan ZP,Cheng JM,Liu QX,Liu R,Wang JH

更新日期：2015-05-26 00:00:00

abstract：PURPOSE:To explore whether changes in tumor size impact survival in advanced non-small-cell lung cancer (NSCLC) after target therapy, especially in patients with evaluation of stable disease (SD), and to review the applicability of the Response Evaluation Criteria in Solid Tumors (RECIST) criteria in target therapy. P...

journal_title：OncoTargets and therapy

authors： Zhang J,Huang Y,Li X,Guo Y,Zhao Y,Xue C,Hu Z,Zhang L,Zhao H

更新日期：2012-01-01 00:00:00

abstract：:To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration-cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of respon...

journal_title：OncoTargets and therapy

authors： Raimondi C,Gradilone A,Naso G,Cortesi E,Gazzaniga P

更新日期：2014-04-17 00:00:00

abstract：Purpose:Non-small cell lung cancer (NSCLC) patients with EGFR mutation are suffering from a high incidence of brain metastasis (BM). It is still controversial whether cranial radiotherapy could be delayed when the EGFR-tyrosine kinase inhibitors (TKIs) used as first-line therapy for EGFR-positive patients with BM. This...

journal_title：OncoTargets and therapy

authors： An N,Wang H,Li J,Zhai X,Jing W,Jia W,Kong L,Zhu H,Yu J

更新日期：2019-10-08 00:00:00

abstract：:Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tum...

journal_title：OncoTargets and therapy

authors： Huang G,Zhu G

更新日期：2018-06-11 00:00:00

abstract：:Multiple drug resistance is still an unsolved problem in cancer therapy. Our previous study demonstrated that the chemotherapeutic drug doxorubicin (Dox) induced upregulation of P-glycoprotein (P-gp) in endothelial cells, resulting in a 20-fold increase in drug resistance and reduced efficiency of Dox treatment in a m...

journal_title：OncoTargets and therapy

authors： Huang L,Hu C,Di Benedetto M,Varin R,Liu J,Wang L,Vannier JP,Jin J,Janin A,Lu H,Li H

更新日期：2014-12-04 00:00:00