Cervical Cancer: Emerging Immune Landscape and Treatment.

abstract：Background:A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human ...

journal_title：OncoTargets and therapy

authors： Li S,Wen D,Che S,Cui Z,Sun Y,Ren H,Hao J

更新日期：2018-06-06 00:00:00

abstract：:Cancers of the stomach and gastro-esophageal junction represent a significant challenge in oncology. Despite some recent advances in genetic categorization and the development of novel agents, outcomes remain poor. The vascular endothelial growth factor receptor 2 monoclonal antibody ramucirumab is the first targeted ...

journal_title：OncoTargets and therapy

authors： Davidson M,Smyth EC,Cunningham D

更新日期：2016-07-25 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：Purpose:B7 homologue 6 (B7-H6) has been found at an up-regulated level in multiple cancer cells and identified to be positively correlated with inferior clinical features. In non-Hodgkin lymphoma (NHL), however, the roles of B7-H6 and the underlying mechanism of action remain unclear. Through in vivo and in vitro exper...

journal_title：OncoTargets and therapy

authors： Yang S,Yuan L,Wang Y,Zhu M,Wang J,Ke X

更新日期：2020-06-18 00:00:00

abstract：Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...

journal_title：OncoTargets and therapy

authors： He Y,Wang Y,Zhao S,Zhao C,Zhou C,Hirsch FR

更新日期：2018-08-13 00:00:00

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00

abstract：Background:The diagnosis rate of early stage esophageal squamous cell carcinoma (ESCC) is low due to the lack of specific tumor markers. Seeking for these markers is beneficial to improve the early diagnosis rate and the prognosis of patients. This study profiles the differentially expressed proteins of early stage ESC...

journal_title：OncoTargets and therapy

authors： Tong Q,Wang XL,Li SB,Yang GL,Jin S,Gao ZY,Liu XB

更新日期：2018-09-12 00:00:00

abstract：Purpose:Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging ar...

journal_title：OncoTargets and therapy

authors： Boogerd LS,van der Valk MJ,Boonstra MC,Prevoo HA,Hilling DE,van de Velde CJ,Sier CF,Fariña Sarasqueta A,Vahrmeijer AL

更新日期：2018-03-23 00:00:00

abstract：BACKGROUND:Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isofor...

journal_title：OncoTargets and therapy

authors： Vicari L,La Rosa C,Forte S,Calabrese G,Colarossi C,Aiello E,Salluzzo S,Memeo L

更新日期：2016-10-11 00:00:00

abstract：Background:The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma. Patients and methods:A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (ge...

journal_title：OncoTargets and therapy

authors： Nie Y,Liu H,Tan X,Wang H,Li F,Li C,Han P,Lyv X,Xu X,Guo M

更新日期：2019-01-10 00:00:00

abstract：:The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...

journal_title：OncoTargets and therapy

authors： He DX,Ma X

更新日期：2016-03-01 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：Introduction:A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), whose expression is dysregulated in various cancers, is implicated in cancer development. Herein, we aimed to investigate the functional role of ADAMTS8 in breast cancer (BC) and explore the underlying mechanisms. Methods:The protein...

journal_title：OncoTargets and therapy

authors： Zhang K,Tian R,Wang G,Zhang J,Ma H,Hu X,Xi J,Wang G

更新日期：2020-08-21 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:Permanent prostate brachytherapy (PPB) is an effective treatment choice for low and intermediate risk prostate cancer (PCa). However, the impact of PPB on tumor immune status is still poorly understood. This study aimed to assess the immune status in PCa patients before and at different time points after PPB...

journal_title：OncoTargets and therapy

authors： Du E,Wang L,Li CY,Zhang CW,Qu YC,Liu RL,Xu Y,Yang K,Zhang ZH

更新日期：2017-05-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) tumor thrombus rarely occurs, its prognosis is extremely poor. A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with stereotactic body radiotherapy (SBRT). A radiation dose of 40...

journal_title：OncoTargets and therapy

authors： Shui Y,Zhu X,Wu J,Liang T,Wei Q

更新日期：2019-07-04 00:00:00

abstract：Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...

journal_title：OncoTargets and therapy

authors： Han M,Chen L,Wang Y

更新日期：2018-09-28 00:00:00

abstract：:The incidence of lung neuroendocrine carcinomas, which originate from lung neuroendocrine cells, is 1.35/100,000, among which mixed neuroendocrine carcinomas are very rare. Because of the heterogeneity and significant differences in sensitivity to treatments, there is no effective treatment, and the prognosis is poor....

journal_title：OncoTargets and therapy

authors： Zhang B,Wang D,Zhang X,Cui X,Kong L,Li M,Yu J

更新日期：2019-11-14 00:00:00

abstract：Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...

journal_title：OncoTargets and therapy

authors： Liu X,Song Y,Liang P,Su T,Zhang H,Zhao X,Yuan Z,Wang P

更新日期：2017-11-06 00:00:00

abstract：Purpose:Non-small cell lung cancer (NSCLC) patients with EGFR mutation are suffering from a high incidence of brain metastasis (BM). It is still controversial whether cranial radiotherapy could be delayed when the EGFR-tyrosine kinase inhibitors (TKIs) used as first-line therapy for EGFR-positive patients with BM. This...

journal_title：OncoTargets and therapy

authors： An N,Wang H,Li J,Zhai X,Jing W,Jia W,Kong L,Zhu H,Yu J

更新日期：2019-10-08 00:00:00

abstract：Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...

journal_title：OncoTargets and therapy

authors： Su X,Zhang J,Fu C,Xiao M,Wang C

更新日期：2020-04-21 00:00:00

abstract：:This report describes a patient with intravascular large B-cell lymphoma (IVLBCL) with central nervous system involvement at the time of diagnosis who achieved complete remission for over 5 years in response to therapy. The patient, a 71 year-old woman, was previously healthy with the exception of taking verapamil for...

journal_title：OncoTargets and therapy

authors： Sawada T,Omuro Y,Kobayashi T,Hishima T,Koizumi F,Kanemasa Y,Shimoyama T,Sasaki E,Maeda Y

更新日期：2014-11-18 00:00:00

abstract：Background:Bladder cancer (BC) is one of the most prevalent malignancies of the genitourinary system, yet the underlying mechanism of BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers deve...

journal_title：OncoTargets and therapy

authors： Han N,Yuan F,Xian P,Liu N,Liu J,Zhang H,Zhang H,Yao K,Yuan G

更新日期：2019-09-16 00:00:00

abstract：:Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted...

journal_title：OncoTargets and therapy

authors： Guan Z,Yu X,Wang H,Wang H,Zhang J,Li G,Cao J,Teng L

更新日期：2015-01-05 00:00:00

abstract：Background:Erlotinib is a commonly used molecular-targeted drug for the treatment of tongue cancer. However, the development of acquired resistance to erlotinib hampers its therapeutic use. Materials and methods:To analyze the erlotinib resistance, long-term and short term survival assay were used to compare the resis...

journal_title：OncoTargets and therapy

authors： Huang K,Liu D

更新日期：2018-09-05 00:00:00

abstract：PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...

journal_title：OncoTargets and therapy

authors： Chen J,Li H,Pang R,Huang J

更新日期：2017-04-06 00:00:00

abstract：:Normal astrocytes are more resistant to radiation than glioma cells. Radiation-resistant glioma cells and normal astrocytes usuallly share similar mechanisms of radioresistance. Investigation of the underlying mechanisms of differential radiation response between normal astrocytes and glioma cells is thus significant ...

journal_title：OncoTargets and therapy

authors： Gong L,Gu J,Ge J,Wu X,Zhang C,Yang C,Weng W,Gao G,Feng J,Mao Q

更新日期：2017-12-04 00:00:00

abstract：Purpose:Here, we investigated the involvement of the miR-188-5p/inhibitor of the DNA binding 4 (ID4) axis in retinoblastoma (Rb). Patients and methods:We included 35 Rb tissues and the corresponding adjacent normal tissues. RT-qPCR, Western blot, lentivirus transfection, measurement of cell migration in vitro, and chi...

journal_title：OncoTargets and therapy

authors： Yang M,Li Y,Wei W

更新日期：2019-11-27 00:00:00

abstract：AIM:This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is...

journal_title：OncoTargets and therapy

authors： Macchia G,Deodato F,Cilla S,Cammelli S,Guido A,Ferioli M,Siepe G,Valentini V,Morganti AG,Ferrandina G

更新日期：2017-07-26 00:00:00

abstract：:Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....

journal_title：OncoTargets and therapy

authors： Yi F,Du J,Ni W,Liu W

更新日期：2017-02-20 00:00:00