Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression.

abstract：:This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

journal_title：OncoTargets and therapy

authors： Liu P,Zhu Y,Liu L

更新日期：2015-06-04 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：:Liposarcoma (LPS) is the most common type of soft-tissue sarcoma. Complete surgical resection is the only curative means for localized disease; however, both radiation and conventional cytotoxic chemotherapy remain controversial for metastatic or unresectable disease. An increasing number of trials with novel targeted...

journal_title：OncoTargets and therapy

authors： Guan Z,Yu X,Wang H,Wang H,Zhang J,Li G,Cao J,Teng L

更新日期：2015-01-05 00:00:00

abstract：:Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The...

journal_title：OncoTargets and therapy

authors： Tarazona N,Navarro L,Cejalvo JM,Gambardella V,Pérez-Fidalgo JA,Sempere A,Navarro S,Cervantes A

更新日期：2015-05-14 00:00:00

abstract：AIM:This study was designed to investigate the predictive and prognostic values of serum vascular endothelial growth factor (VEGF) level in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. METHODS:Patients' peripheral blood samples were collected prior to chemotherapy and after 1 w...

journal_title：OncoTargets and therapy

authors： Zang J,Hu Y,Xu X,Ni J,Yan D,Liu S,He J,Xue J,Wu J,Feng J

更新日期：2017-01-18 00:00:00

abstract：Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...

journal_title：OncoTargets and therapy

authors： Yuan G,Cheng X,Li Q,Zang M,Huang W,Fan W,Wu T,Ruan J,Dai W,Yu W,Chen M,Guo Y,Hu X,Chen J

更新日期：2020-12-09 00:00:00

abstract：:Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tum...

journal_title：OncoTargets and therapy

authors： Huang G,Zhu G

更新日期：2018-06-11 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...

journal_title：OncoTargets and therapy

authors： Zong M,Jia L,Li L

更新日期：2013-01-01 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Objective:As an epidermal growth factor, receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib demonstrates a good therapeutic effect in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). However, an overwhelming majority of these patients inevitably develop resistance against gefitinib. Unfortunately, th...

journal_title：OncoTargets and therapy

authors： Zhang D,Han LL,Du F,Liu XM,Li J,Wang HH,Song MH,Li Z,Li GY

更新日期：2019-11-18 00:00:00

abstract：:Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...

journal_title：OncoTargets and therapy

authors： Yan Y,Grothey A

更新日期：2015-10-15 00:00:00

abstract：Purpose:Minimally invasive esophagectomy is increasingly performed for esophageal or gastroesophageal junctional cancer, with advantages of improved perioperative outcomes in comparison with open esophagectomy. McKeown and Ivor Lewis are widely used procedures of minimally invasive esophagectomy, and there have been co...

journal_title：OncoTargets and therapy

authors： Deng J,Su Q,Ren Z,Wen J,Xue Z,Zhang L,Chu X

更新日期：2018-09-20 00:00:00

abstract：:Aberrant methylation of CpG dinucleotides is a commonly observed epigenetic modification in human cancer. Thus, detection of aberrant gene promoter methylation as a tool for diagnosis of tumors or as a prognostic marker has been widely described for many types of cancers, including nonsmall cell lung cancer (NSCLC). E...

journal_title：OncoTargets and therapy

authors： Xue R,Yang C,Zhao F,Li D

更新日期：2014-10-31 00:00:00

abstract：Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...

journal_title：OncoTargets and therapy

authors： Du X,Wang T,Wang Z,Wu X,Gu Y,Huang Q,Wang J,Xie J

更新日期：2020-03-09 00:00:00

abstract：:[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2017-04-27 00:00:00

abstract：BACKGROUND:We aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT) combined with chemotherapy. PATIENTS AND METHODS:From April 2006 to December 2011, ...

journal_title：OncoTargets and therapy

authors： Maklad AM,Bayoumi Y,Senosy Hassan MA,Elawadi AA,AlHussain H,Elyamany A,Aldhahri SF,Al-Qahtani KH,AlQahtani M,Tunio MA

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...

journal_title：OncoTargets and therapy

authors： Wu SG,Sun JY,Zhou J,Li FY,Lin Q,Lin HX,He ZY

更新日期：2014-02-15 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...

journal_title：OncoTargets and therapy

authors： Wang W,Wang J,Zhang X,Liu G

更新日期：2019-09-11 00:00:00

abstract：Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...

journal_title：OncoTargets and therapy

authors： Li X,Li F,Wang F,Li J,Lin C,Du J

更新日期：2018-05-22 00:00:00

abstract：BACKGROUND:Considerable interest is directed toward the enzyme aromatase (CYP19A1) and the development of cancer, due to CYP19A1's role in estrogen biosynthesis. Several cancers display excessive intra-tumor accumulation of estrogens, and aromatase inhibitors are used for treatment. The CYP19A1 gene exhibits polymorphi...

journal_title：OncoTargets and therapy

authors： Al-Mukaynizi FB,Alanazi M,Al-Daihan S,Parine NR,Almadi M,Aljebreen A,Azzam N,Alharbi O,Arafah M,Warsy A

更新日期：2017-09-14 00:00:00

abstract：:ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...

journal_title：OncoTargets and therapy

authors： Cai C,Long Y,Li Y,Huang M

更新日期：2020-08-20 00:00:00

abstract：:The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...

journal_title：OncoTargets and therapy

authors： He DX,Ma X

更新日期：2016-03-01 00:00:00

abstract：Background:Breast cancer is the most common tumor among women. miR-638 has been demonstrated to play an important role in various cancers. Purpose:In this study, we aimed to investigate the function and prognostic value of miR-638 in breast cancer. Methods:Quantitative real-time polymerase chain reaction analysis was...

journal_title：OncoTargets and therapy

authors： Li M,Wang J,Liu H

更新日期：2018-10-12 00:00:00

abstract：PURPOSE:To evaluate whether the addition of two biological markers (MYC and BCL-2 protein overexpression) improves the stratification of high-risk patients with diffuse large B-cell lymphoma (DLBCL). METHOD:Seven risk factors were identified at diagnosis, and a maximum of 7 points were assigned to each patient. The pa...

journal_title：OncoTargets and therapy

authors： Wang J,Zhou M,Xu JY,Chen B,Ouyang J

更新日期：2015-09-18 00:00:00

abstract：Purpose:Cervical squamous cell carcinoma (CSCC) seriously affects women's health worldwide, and it is of great significance to illuminate the specific role of circRNAs in CSCC. Materials and Methods:Three mRNA datasets, two miRNA datasets and one circRNA dataset of CSCC, downloaded from GEO, were utilized in this stud...

journal_title：OncoTargets and therapy

authors： Wu Q,Liu P,Lao G,Liu Y,Zhang W,Ma C

更新日期：2020-08-25 00:00:00

abstract：Purposes:The main aim of the study was to investigate the dosimetric difference between acuros XB algorithm (AXB), anisotropic analytic algorithm (AAA), and pencil beam convolution (PBC) algorithm in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC). Patients and Methods:Thirty-eig...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang D,Su H,Dai Z,Dai J,Liu H,Xie C,Yu H

更新日期：2019-08-12 00:00:00

abstract：Background:Although there have been great advances in mechanisms and therapeutic methods of prostate cancer, the mortality rate of prostate cancer remains high. The castration-resistant prostate cancer (CRPC), which develops from hormone-sensitive prostate cancer, foreshadows a more dismal outcome. Concomitant with the...

journal_title：OncoTargets and therapy

authors： Wang K,Ruan H,Xu T,Liu L,Liu D,Yang H,Zhang X,Chen K

更新日期：2018-05-28 00:00:00

abstract：OBJECTIVE:To study microRNA (miR)-20a expression in hepatocellular carcinoma (HCC) and its effects on the proliferation, migration, and invasion of HepG2. METHODS:The real-time polymerase chain reaction was used to detect the expression of miR-20a in HCC tissue and normal tissue, as well as in HCC cell lines and norma...

journal_title：OncoTargets and therapy

authors： Chen GS,Zhou N,Li JQ,Li T,Zhang ZQ,Si ZZ

更新日期：2016-05-27 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Tumor cells before and after epidermal growth-factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) therapy might display different characteristics. The aim of this study was to evaluate the influence of prior EGFR TKI therapy on the efficacy of subsequent pemetrexed plus platinum (PP) in advanced chemonaïv...

journal_title：OncoTargets and therapy

authors： Tseng JS,Yang TY,Chen KC,Hsu KH,Yu CJ,Liao WY,Tsai CR,Tsai MH,Yu SL,Su KY,Chen JJ,Chen HY,Chang GC

更新日期：2014-05-23 00:00:00