Comparative analyses of postoperative complications and prognosis of different surgical procedures in stage II endometrial carcinoma treatment.

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：Purpose:MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods:miR-939 expression ...

journal_title：OncoTargets and therapy

authors： Situ J,Zhang H,Jin Z,Li K,Mao Y,Huang W

更新日期：2020-05-18 00:00:00

abstract：AIM:This study was designed to investigate the predictive and prognostic values of serum vascular endothelial growth factor (VEGF) level in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. METHODS:Patients' peripheral blood samples were collected prior to chemotherapy and after 1 w...

journal_title：OncoTargets and therapy

authors： Zang J,Hu Y,Xu X,Ni J,Yan D,Liu S,He J,Xue J,Wu J,Feng J

更新日期：2017-01-18 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...

journal_title：OncoTargets and therapy

authors： Gullapalli S,Remon J,Hendriks LEL,Lopes G

更新日期：2020-07-14 00:00:00

abstract：Purpose:Minimally invasive esophagectomy is increasingly performed for esophageal or gastroesophageal junctional cancer, with advantages of improved perioperative outcomes in comparison with open esophagectomy. McKeown and Ivor Lewis are widely used procedures of minimally invasive esophagectomy, and there have been co...

journal_title：OncoTargets and therapy

authors： Deng J,Su Q,Ren Z,Wen J,Xue Z,Zhang L,Chu X

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:"Gefitinib" is a first-generation epidermal growth factor receptor tyrosine-kinase inhibitor. More than half of patients receiving gefitinib develop acne-like eruption. Evozac(®) Calming Skin Spray (Evaux Laboratoires, Évaux-les-Bains, France) is made of Évaux thermal spring water and commonly used for the t...

journal_title：OncoTargets and therapy

authors： Wang Y,Yang Y,Xu J,Yu J,Liu X,Gao R,Zhang L

更新日期：2014-07-10 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...

journal_title：OncoTargets and therapy

authors： Chen PF,Wang F,Nie JY,Feng JR,Liu J,Zhou R,Wang HL,Zhao Q

更新日期：2018-10-02 00:00:00

abstract：:The fusion of echinoderm microtubule-associated protein-like 4 with anaplastic lymphoma kinase (ALK) was identified as a transforming gene for lung cancer in 2007. This genetic rearrangement accounts for 2%-5% of non-small-cell lung cancer (NSCLC) cases, occurring predominantly in younger individuals with adenocarcino...

journal_title：OncoTargets and therapy

authors： Iwama E,Okamoto I,Harada T,Takayama K,Nakanishi Y

更新日期：2014-03-05 00:00:00

abstract：:This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

journal_title：OncoTargets and therapy

authors： Liu P,Zhu Y,Liu L

更新日期：2015-06-04 00:00:00

abstract：Purpose:Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX. Methods:Microarray analysis was used to identify differentially expressed genes in pacl...

journal_title：OncoTargets and therapy

authors： Guo M,Li S,Zhao X,Yuan Y,Zhang B,Guan Y

更新日期：2020-12-24 00:00:00

abstract：Background:The non-receptor tyrosine kinase Fyn-related kinase (FRK) has been reported to affect cell proliferation in several cancer types. However, its effect on the proliferation of clear cell renal cell carcinoma (ccRCC) remains largely unknown. Purpose:The objective of this study was to investigate the expression...

journal_title：OncoTargets and therapy

authors： Jing ZF,Bi JB,Li ZL,Liu XK,Li J,Zhu YY,Zhang XT,Zhang Z,Li ZH,Kong CZ

更新日期：2019-04-10 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S214060.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-05-26 00:00:00

abstract：:Malignant pericardial effusion (MPCE) is a common complication of advanced malignant tumors, and interferes severely with patient prognosis and quality of life. The standard treatment for this complication is intracavitary perfusion of chemotherapeutic drugs, which is limited by unsatisfactory therapeutic effects and ...

journal_title：OncoTargets and therapy

authors： Chen D,Zhang Y,Shi F,Li M,Zhu H,Kong L,Yu J

更新日期：2015-10-01 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：OBJECTIVE:Resveratrol is a phytoestrogen with various antiproliferative and proapoptotic effects. This in vitro study aimed to analyze the effect of resveratrol on the viability and expression of modulators of apoptosis in GH3 pituitary adenoma cells of the rat. METHODS:GH3 cells were incubated with resveratrol concen...

journal_title：OncoTargets and therapy

authors： Voellger B,Kirches E,Wilisch-Neumann A,Weise A,Tapia-Perez JH,Rupa R,Mawrin C,Firsching R

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...

journal_title：OncoTargets and therapy

authors： Huang J,Zhang Y,Sheng J,Zhang H,Fang W,Zhan J,Zhou T,Chen Y,Liu L,Zhang L

更新日期：2016-09-23 00:00:00

abstract：Objective:As an epidermal growth factor, receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib demonstrates a good therapeutic effect in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). However, an overwhelming majority of these patients inevitably develop resistance against gefitinib. Unfortunately, th...

journal_title：OncoTargets and therapy

authors： Zhang D,Han LL,Du F,Liu XM,Li J,Wang HH,Song MH,Li Z,Li GY

更新日期：2019-11-18 00:00:00

abstract：Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...

journal_title：OncoTargets and therapy

authors： Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PG

更新日期：2020-11-16 00:00:00

abstract：Objective:Long non-coding RNA (lncRNA) ANRIL is emerging as a crucial role in ovarian cancer progression and prognosis. However, the precise molecular mechanism of ANRIL on ovarian cancer is not known. Thus, we aim to study the underlying mechanism of ANRIL on the action. Methods:The MTT assay assessed cell viability....

journal_title：OncoTargets and therapy

authors： Wang K,Hu YB,Zhao Y,Ye C

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...

journal_title：OncoTargets and therapy

authors： Leal P,Garcia P,Sandoval A,Buchegger K,Weber H,Tapia O,Roa JC

更新日期：2013-10-03 00:00:00

abstract：Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...

journal_title：OncoTargets and therapy

authors： Shi H,Luo K,Huang W

更新日期：2020-08-26 00:00:00

abstract：Objective:Osteoclastogenesis is a key process in osteolytic bone metastasis (BM). Previous studies indicated that some miRNAs could regulate cancers progression and osteoclastogenesis. Our purpose was to investigate the roles of lung cancer cells-derived circulating miR-21 on osteoclastogenesis and its clinical signifi...

journal_title：OncoTargets and therapy

authors： Zhao Q,Liu C,Xie Y,Tang M,Luo G,Chen X,Tian L,Yu X

更新日期：2020-03-31 00:00:00

abstract：OBJECTIVE:Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantatio...

journal_title：OncoTargets and therapy

authors： Ocal N,Yildiz B,Karadurmus N,Dogan D,Ozaydin S,Ocal R,Ozturk M,Arpaci F,Bilgic H

更新日期：2016-12-09 00:00:00

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：:Purpose: NSD3 (WHSC1L1) is a protein lysine methyltransferase that is recurrently amplified (8p11.23) in several cancer types, and its upregulation is involved in tumor cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to evaluate its potential function as an oncogenic force in colo...

journal_title：OncoTargets and therapy

authors： Yi L,Yi L,Liu Q,Li C

更新日期：2019-05-21 00:00:00

abstract：:Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that is cured in as few as 15%-40% of cases. Tremendous improvements in AML prognostication arose from a comprehensive analysis of leukemia cell genomes. Among normal karyotype AML cases, mutations in the FLT3 gene are the ones most commonly detect...

journal_title：OncoTargets and therapy

authors： Hospital MA,Green AS,Maciel TT,Moura IC,Leung AY,Bouscary D,Tamburini J

更新日期：2017-02-03 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：PURPOSE:This study aimed to explore the molecular mechanisms associated with bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) in patients with multiple myeloma (MM). METHODS:The gene expression profile GSE7116 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) fro...

journal_title：OncoTargets and therapy

authors： Sun J,Wen X,Jin F,Li Y,Hu J,Sun Y

更新日期：2015-09-22 00:00:00