Resveratrol decreases B-cell lymphoma-2 expression and viability in GH3 pituitary adenoma cells of the rat.

abstract：:Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tum...

journal_title：OncoTargets and therapy

authors： Huang G,Zhu G

更新日期：2018-06-11 00:00:00

abstract：BACKGROUND:Recent studies show that epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression and poor prognosis of carcinoma through multiple mechanisms. Both inflammation and changing of epithelium have a close relationship with tumorigenesis of gastric cancer. Howe...

journal_title：OncoTargets and therapy

authors： Yan Y,Zhang J,Li JH,Liu X,Wang JZ,Qu HY,Wang JS,Duan XY

更新日期：2016-06-30 00:00:00

abstract：Background:miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective:This study aimed to analyze the expression profile of miR-486-5p in tumor ti...

journal_title：OncoTargets and therapy

authors： Zheng X,Xu K,Zhu L,Mao M,Zhang F,Cui L

更新日期：2020-05-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) tumor thrombus rarely occurs, its prognosis is extremely poor. A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with stereotactic body radiotherapy (SBRT). A radiation dose of 40...

journal_title：OncoTargets and therapy

authors： Shui Y,Zhu X,Wu J,Liang T,Wei Q

更新日期：2019-07-04 00:00:00

abstract：BACKGROUND:The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS:A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy...

journal_title：OncoTargets and therapy

authors： Joo JH,Kim YJ,Kim YS,Cho YP,Lee HY,Jeong CY,Kwak J,Cho BC

更新日期：2016-05-24 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...

journal_title：OncoTargets and therapy

authors： Han M,Chen L,Wang Y

更新日期：2018-09-28 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:"Gefitinib" is a first-generation epidermal growth factor receptor tyrosine-kinase inhibitor. More than half of patients receiving gefitinib develop acne-like eruption. Evozac(®) Calming Skin Spray (Evaux Laboratoires, Évaux-les-Bains, France) is made of Évaux thermal spring water and commonly used for the t...

journal_title：OncoTargets and therapy

authors： Wang Y,Yang Y,Xu J,Yu J,Liu X,Gao R,Zhang L

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:In patients with gastric cancer (GC), survival is poor, given the late diagnosis. Risk-stratifying these patients earlier could help improve care. We determined whether combining preoperative albumin concentration and the neutrophil lymphocyte ratio (COA-NLR) could predict overall survival (OS) better than o...

journal_title：OncoTargets and therapy

authors： Sun X,Wang J,Liu J,Chen S,Liu X

更新日期：2016-07-27 00:00:00

abstract：Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...

journal_title：OncoTargets and therapy

authors： Auliac JB,Guisier F,Bizieux A,Assouline P,Bernardini M,Lamy R,Justeau G,François G,Damotte D,Chouaïd C

更新日期：2020-12-30 00:00:00

abstract：:Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...

journal_title：OncoTargets and therapy

authors： Baldo P,Cecco S

更新日期：2017-11-08 00:00:00

abstract：Purpose:The proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological ...

journal_title：OncoTargets and therapy

authors： Wang Z,Li M,Huang Y,Ma L,Zhu H,Kong L,Yu J

更新日期：2018-05-04 00:00:00

abstract：:Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of d...

journal_title：OncoTargets and therapy

authors： Prestin K,Olbert M,Hussner J,Isenegger TL,Gliesche DG,Böttcher K,Zimmermann U,Meyer Zu Schwabedissen HE

更新日期：2016-08-08 00:00:00

abstract：Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...

journal_title：OncoTargets and therapy

authors： Lian G,Yuan J,Gao Y

更新日期：2020-02-17 00:00:00

abstract：Objective:To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL). Methods:Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible...

journal_title：OncoTargets and therapy

authors： Deng S,Lin S,Shen J,Zeng Y

更新日期：2019-03-28 00:00:00

abstract：Objective:This study aims to uncover the progression of thyroid carcinoma influenced by the m6A methyltransferase METTL3 through regulating m6A methylation on TCF1 mRNA and the activated Wnt pathway. Methods:Thyroid carcinoma tissues and paracancerous ones were collected for detecting levels of METTL3 and TCF1. Potent...

journal_title：OncoTargets and therapy

authors： Wang K,Jiang L,Zhang Y,Chen C

更新日期：2020-02-21 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor tyrosine kinases. Particularly, FGFR2 has been identified as a potential target for tyrosine kinase inhibitor (TKI) treatment. Except for immunohistochemistry and fluorescence in situ hybridization, next-generation sequencing (NGS)...

journal_title：OncoTargets and therapy

authors： Ying X,Tu J,Wang W,Li X,Xu C,Ji J

更新日期：2019-11-06 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little informat...

journal_title：OncoTargets and therapy

authors： Lv J,Lin S,Peng P,Cai C,Deng J,Wang M,Li X,Lin R,Lin Y,Fang A,Li Q

更新日期：2017-02-28 00:00:00

abstract：Introduction:Cervical cancer, one of the most common malignant gynecological tumors, is a significant burden on the health of females worldwide. The purpose of this study was to investigate genes associated with lymph node metastasis in cervical cancer. Methods:We report on the lymph node metastasis-associated gene, s...

journal_title：OncoTargets and therapy

authors： Jia Y,Li H,Liu G,Song F

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...

journal_title：OncoTargets and therapy

authors： Huang J,Zhang Y,Sheng J,Zhang H,Fang W,Zhan J,Zhou T,Chen Y,Liu L,Zhang L

更新日期：2016-09-23 00:00:00

abstract：:Purpose: Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients are still comparatively low. Therefore, potential therapeutic targets are urgently needed to improve the survival of lung cancer patients. In t...

journal_title：OncoTargets and therapy

authors： Sun H,Liu K,Huang J,Sun Q,Shao C,Luo J,Xu L,Shen Y,Ren B

更新日期：2019-04-17 00:00:00

abstract：Background:Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysregulated in tumors and critical for tumor-cell proliferation a...

journal_title：OncoTargets and therapy

authors： Li X,Zhu G,Yao X,Wang N,Hu R,Kong Q,Zhou D,Long L,Cai J,Zhou W

更新日期：2018-12-11 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is prevalent throughout the world. The aim of this study is to explore new long non-coding RNAs (lncRNAs) associated with hepatocellular carcinoma and detect their expression levels in hepatocellular carcinoma cell lines and tissues. These results will provide new clues on furt...

journal_title：OncoTargets and therapy

authors： Wang B,Yang S,Zhao W

更新日期：2020-10-14 00:00:00

abstract：Purpose:Stomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer. Materials and Methods:By integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) ...

journal_title：OncoTargets and therapy

authors： Zhang X,Zheng P,Li Z,Gao S,Liu G

更新日期：2020-08-04 00:00:00

abstract：Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...

journal_title：OncoTargets and therapy

authors： Su X,Zhang J,Fu C,Xiao M,Wang C

更新日期：2020-04-21 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：:Defects in the innate immune system, particularly in Toll-like receptors (TLRs), have been reported in several cigarette smoke-promoted diseases. The aim of this study was to examine the impact of tobacco smoke on allelic frequencies of TLR4 single-nucleotide polymorphisms (SNPs) and to compare the genotypic distribut...

journal_title：OncoTargets and therapy

authors： Kohailan M,Alanazi M,Rouabhia M,Al Amri A,Parine NR,Semlali A

更新日期：2017-02-09 00:00:00

abstract：Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...

journal_title：OncoTargets and therapy

authors： Wang D,Xiang Y,Wu M,Shen K,Yang J,Huang H,Ren T

更新日期：2018-03-07 00:00:00

abstract：Background:Cellular senescence-inhibited gene (CSIG) strongly prolongs the progression of replicative senescence. However, roles and mechanisms of CSIG in tumor progression have not been studied widely. Methods:Roles of CSIG in migration and proliferation of SMMC7721 and Huh7 cells were analyzed by transwell or cell v...

journal_title：OncoTargets and therapy

authors： Cheng Q,Tong TJ,Li Z,Hu SH,Chen DB,Wang SQ,Zhu JY

更新日期：2019-03-15 00:00:00