Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m6A Methylation on TCF1.

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：:The chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) axis plays an important role in tumorigenesis, metastasis, and recurrence of tumors. Its single nucleotide polymorphisms (SNPs) are associated with patient survival in several types of cancer. However, the prognostic value of SNPs in nasopharyngeal carcinoma ...

journal_title：OncoTargets and therapy

authors： Chen R,Xu Y,Du X,Liu N,Li Y,He Q,Tang L,Mao Y,Sun Y,Chen L,Ma J

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：:The clinicopathological and prognostic significance of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still discrepant. Systematic searches were performed in PubMed, Web of Science, Scopus, Ovid, and the Cochran Library databases for...

journal_title：OncoTargets and therapy

authors： Su X,Jiang X,Wang W,Wang H,Xu X,Lin A,Teng X,Wu H,Teng L

更新日期：2016-11-11 00:00:00

abstract：Background:MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure. Methods:The effect of miR-647 and TRAF2 on A549 and H1299 cells was explored through Methyl thiazolyl tetrazolium (MTT) assay, colony formation and cell cy...

journal_title：OncoTargets and therapy

authors： Zhang YS,Chen T,Cai YJ,Dong J,Bai F,Gao X,Tian L,Duan N,Liu D

更新日期：2018-10-10 00:00:00

abstract：PURPOSE:To evaluate whether the addition of two biological markers (MYC and BCL-2 protein overexpression) improves the stratification of high-risk patients with diffuse large B-cell lymphoma (DLBCL). METHOD:Seven risk factors were identified at diagnosis, and a maximum of 7 points were assigned to each patient. The pa...

journal_title：OncoTargets and therapy

authors： Wang J,Zhou M,Xu JY,Chen B,Ouyang J

更新日期：2015-09-18 00:00:00

abstract：Introduction:Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma. Met...

journal_title：OncoTargets and therapy

authors： Guo Y,Yang L,Lei S,Tan W,Long J

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:The PI3K family participates in multiple signaling pathways to regulate cellular functions. PI3K/Akt signaling pathway plays an important role in tumorigenesis and development. O-GlcNAcylation, a posttranslational modification, is thought to modulate a wide range of biological processes, such as transcriptio...

journal_title：OncoTargets and therapy

authors： Zhang P,Wang C,Ma T,You S

更新日期：2015-11-09 00:00:00

abstract：Background:The immunosuppressive facet and tumorigenic role of TNF-α have been revealed in osteosarcoma (OS). Long noncoding RNA THRIL is identified to regulate TNF-α expression and participates in immune response. Thus, investigations on the clinical expression pattern of THRIL/TNF-α signal in OS would provide a poten...

journal_title：OncoTargets and therapy

authors： Xu B,Jin X,Yang T,Zhang Y,Liu S,Wu L,Ying H,Wang Z

更新日期：2020-01-07 00:00:00

abstract：PURPOSE:This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS:A prospective, open-label, single-arm Phase II study (Clinical...

journal_title：OncoTargets and therapy

authors： Wang J,Tian Y,Tang Y,Wang X,Li N,Ren H,Fang H,Feng Y,Wang S,Song Y,Liu Y,Wang W,Li Y,Jin J

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:Current cancer treatments have unexpected side effects of which the death of normal cells is one. In some cancers, iron nanoparticles (NPs) can be subjected to diagnosis and passive targeting treatment. Cold atmospheric plasma (CAP) has a proven induction of selective cell death ability. In this study, we ha...

journal_title：OncoTargets and therapy

authors： Jalili A,Irani S,Mirfakhraie R

更新日期：2016-09-28 00:00:00

abstract：:Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes with different biology showing different sensitivity to therapeutic agents. For decades, the standard first-line systemic treatment o...

journal_title：OncoTargets and therapy

authors： Recine F,Bongiovanni A,Riva N,Fausti V,De Vita A,Mercatali L,Liverani C,Miserocchi G,Amadori D,Ibrahim T

更新日期：2017-02-23 00:00:00

abstract：Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...

journal_title：OncoTargets and therapy

authors： Wu W,Wang X,Shan C,Li Y,Li F

更新日期：2018-08-20 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：Background:Intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two of the main treatment techniques for cervical cancer. Whether either technique significantly reduces irradiated volumes of organs at risk (OARs) remains controversial. The aim of this study was to explore which o...

journal_title：OncoTargets and therapy

authors： Bai W,Kou C,Yu W,Li Y,Hua W,Yu L,Wang J

更新日期：2018-10-18 00:00:00

abstract：:[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2017-04-27 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：Background:Bladder cancer is a serious threat to human health. It is meaningful to study the pathogenesis of bladder cancer. Long non-coding RNAs (lncRNAs) are reported to promote or inhibit bladder cancer development. However, the role of lncRNA BCAR4 in the regulation of bladder cancer remains unclear. Purpose:This ...

journal_title：OncoTargets and therapy

authors： Wang X,He H,Rui W,Xie X,Wang D,Zhu Y

更新日期：2020-03-24 00:00:00

abstract：PURPOSE:Hypoxia is a common phenomenon encountered in solid cancers, leading to chemotherapy resistance and therefore to aggressiveness of the disease. The homeostatic response to hypoxia is mediated by hypoxiainducible factor-1 (HIF-1). The aim of this study was to investigate the impact of HIF1α in patients with prim...

journal_title：OncoTargets and therapy

authors： Braicu EI,Luketina H,Richter R,Cacsire Castillo-Tong D,Lambrechts S,Mahner S,Concin N,Mentze M,Zeillinger R,Vergote I,Sehouli J

更新日期：2014-09-11 00:00:00

abstract：Objective:Osteoclastogenesis is a key process in osteolytic bone metastasis (BM). Previous studies indicated that some miRNAs could regulate cancers progression and osteoclastogenesis. Our purpose was to investigate the roles of lung cancer cells-derived circulating miR-21 on osteoclastogenesis and its clinical signifi...

journal_title：OncoTargets and therapy

authors： Zhao Q,Liu C,Xie Y,Tang M,Luo G,Chen X,Tian L,Yu X

更新日期：2020-03-31 00:00:00

abstract：:This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three lung adenocarcinoma associated datasets (GSE43458, GSE10072, and GSE50081), the subjects of which included smokers and nonsmokers, were downloaded to screen the differentially expressed feature genes between ...

journal_title：OncoTargets and therapy

authors： Liu Y,Ni R,Zhang H,Miao L,Wang J,Jia W,Wang Y

更新日期：2016-12-07 00:00:00

abstract：:Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...

journal_title：OncoTargets and therapy

authors： Yan Y,Grothey A

更新日期：2015-10-15 00:00:00

abstract：:Discovered in 2007, anaplastic lymphoma kinase (ALK) gene rearrangements positive (ALK+) lung cancers compose a small subset of non-small cell lung cancer (NSCLC), with rapidly expanded treatments. There are currently several ALK inhibitors, including crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib which ...

journal_title：OncoTargets and therapy

authors： Karachaliou N,Fernandez Bruno M,Bracht JWP,Rosell R

更新日期：2019-06-13 00:00:00

abstract：Background:To investigate the effect of topical application of CpG oligodeoxynucleotide (CpG-ODN) combined with anti-4-1BB antibodies on mouse HCC multiple tumor-bearing models and the degree of improvement of anti-tumor immune response in mice. Materials and Methods:We inoculated each BALB/c male mouse subcutaneously...

journal_title：OncoTargets and therapy

authors： Ma S,Yang X,Zhou H,Zhang C,Kang J,Sun D

更新日期：2020-07-20 00:00:00

abstract：OBJECTIVE:High-mobility group protein 2 (HMGA2) and epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis. However, the clinical significance of HMGA2 and its relationship with EMT markers in nasopharyngeal carcinoma (NPC) is unclear. This study aimed to assess ...

journal_title：OncoTargets and therapy

authors： Xia YY,Yin L,Tian H,Guo WJ,Jiang N,Jiang XS,Wu J,Chen M,Wu JZ,He X

更新日期：2015-01-17 00:00:00

abstract：INTRODUCTION:To investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate. METHODS:The clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical exami...

journal_title：OncoTargets and therapy

authors： Sha J,Bo J,Pan J,Zhang L,Xuan H,Chen W,Li D,Wang Z,Liu D,Huang Y

更新日期：2013-10-24 00:00:00

abstract：Background:The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma. Patients and methods:A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (ge...

journal_title：OncoTargets and therapy

authors： Nie Y,Liu H,Tan X,Wang H,Li F,Li C,Han P,Lyv X,Xu X,Guo M

更新日期：2019-01-10 00:00:00

abstract：:Trastuzumab is a monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). HER2 is amplified or overexpressed in about 15% of breast cancers and is associated with aggressive disease. Clinical benefits of trastuzumab have been established in the treatment of both early and metastatic HE...

journal_title：OncoTargets and therapy

authors： Hamizi S,Freyer G,Bakrin N,Henin E,Mohtaram A,Le Saux O,Falandry C

更新日期：2013-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) possess profound influence on tumor metastases and disease progression. This study aimed to investigate the correlation of CTCs with clinical characteristics and T-cell immunity, and to explore whether CTCs and the subpopulations can serve as an independent prognostic factor in advanced ...

journal_title：OncoTargets and therapy

authors： Sun WW,Xu ZH,Lian P,Gao BL,Hu JA

更新日期：2017-05-04 00:00:00

abstract：Background:Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics and toxic compounds including (pro)carcinogens. BCRP is expressed in many tissues, including...

journal_title：OncoTargets and therapy

authors： Niebudek K,Balcerczak E,Mirowski M,Pietrzak J,Zawadzka I,Żebrowska-Nawrocka M

更新日期：2019-02-27 00:00:00