Molecular profiling in the treatment of colorectal cancer: focus on regorafenib.

abstract：Objective:The biological functions and molecular mechanisms of miR-935 have been widely investigated in various types of cancer. The aim of the present study was to explore the function of miR-935 in glioma. Methods:Bioinformatic analysis and quantitative real-time fluorescent PCR (qRT-PCR) were used to determine the ...

journal_title：OncoTargets and therapy

authors： Huang G,Chen J,Liu J,Zhang X,Duan H,Fang Q

更新日期：2020-10-23 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：BACKGROUND:Tumor cells before and after epidermal growth-factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) therapy might display different characteristics. The aim of this study was to evaluate the influence of prior EGFR TKI therapy on the efficacy of subsequent pemetrexed plus platinum (PP) in advanced chemonaïv...

journal_title：OncoTargets and therapy

authors： Tseng JS,Yang TY,Chen KC,Hsu KH,Yu CJ,Liao WY,Tsai CR,Tsai MH,Yu SL,Su KY,Chen JJ,Chen HY,Chang GC

更新日期：2014-05-23 00:00:00

abstract：:High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metasta...

journal_title：OncoTargets and therapy

authors： Na N,Si T,Huang Z,Miao B,Hong L,Li H,Qiu J,Qiu J

更新日期：2016-11-22 00:00:00

abstract：:The epidermal growth-factor receptor (EGFR) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. This makes EGFR an attractive therapeutic target in this disease. A number of strategies to block EGF...

journal_title：OncoTargets and therapy

authors： Hirte HW

更新日期：2013-04-18 00:00:00

abstract：:Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...

journal_title：OncoTargets and therapy

authors： Baldo P,Cecco S

更新日期：2017-11-08 00:00:00

abstract：:Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...

journal_title：OncoTargets and therapy

authors： Qi T,Dong Y,Gao Z,Xu J

更新日期：2020-12-08 00:00:00

abstract：:This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic castration-resistant prostate cancer (CRPC). RNA was analyzed in blood from six CRPC patients by whole-transcriptome sequencing (total RNA-sequencing) before and after docetaxel ...

journal_title：OncoTargets and therapy

authors： Kohli M,Young CY,Tindall DJ,Nandy D,McKenzie KM,Bevan GH,Donkena KV

更新日期：2015-07-30 00:00:00

abstract：Background:Recent studies showed that aberrant expression of miRNAs causes tumor-suppressing or promoting effects in various cancers including gastric cancer (GC). Our previous studies showed that lots of miRNAs and mRNA expressed differentially in GC and normal tissues. However, the critical miRNAs and mRNA need to be...

journal_title：OncoTargets and therapy

authors： Wang Z,Li Y,Cao J,Zhang W,Wang Q,Zhang Z,Gao Z,Ye Y,Jiang K,Wang S

更新日期：2020-03-03 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...

journal_title：OncoTargets and therapy

authors： Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PG

更新日期：2020-11-16 00:00:00

abstract：:Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...

journal_title：OncoTargets and therapy

authors： Zhao Y,Li Y,Zhang R,Wang F,Wang T,Jiao Y

更新日期：2020-06-11 00:00:00

abstract：Purpose:Stomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer. Materials and Methods:By integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) ...

journal_title：OncoTargets and therapy

authors： Zhang X,Zheng P,Li Z,Gao S,Liu G

更新日期：2020-08-04 00:00:00

abstract：Background:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and exhibit a high frequency of oncogenic KIT or PDGFRA mutations. Tyrosine kinase inhibitors (TKIs) have been mainly used in the treatment of GISTs bearing KIT/PDGFRA mutations. However, other mutation profiles have been found to...

journal_title：OncoTargets and therapy

authors： Chen Q,Li R,Zhang ZG,Deng QT,Li K,Wang H,Yang XX,Wu YS

更新日期：2018-04-20 00:00:00

abstract：PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...

journal_title：OncoTargets and therapy

authors： Qiao GL,Qi WX,Jiang WH,Chen Y,Ma LJ

更新日期：2016-03-31 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the efficacy of sorafenib in preventing and treating tumor recurrence after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria. METHODS:Thirty patients with primary hepatic carcinoma exceeding the Milan criteria underwent ...

journal_title：OncoTargets and therapy

authors： Huang L,Li GM,Zhu JY,Li Z,Li T,Leng XS

更新日期：2012-01-01 00:00:00

abstract：:Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...

journal_title：OncoTargets and therapy

authors： Gogakos AS,Paliouras D,Asteriou C,Rallis T,Lazopoulos A,Chatzinikolaou F,Zissimopoulos A,Tsavlis D,Tsirgogianni K,Zarogoulidis K,Porpodis K,Tsakiridis K,Pitsiou G,Kioumis I,Karapantzos I,Karapantzou C,Sachpekidis N,Zaro

更新日期：2016-01-18 00:00:00

abstract：Background:Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) is a newly identified molecule that has been indicated to discriminate progressive in human solid tumors. However, the role of SPOCD1 in...

journal_title：OncoTargets and therapy

authors： Liu D,Yang Y,Yan A,Yang Y

更新日期：2020-01-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：:Angiogenesis plays an essential role in the development of most solid tumors by delivering nutrients and oxygen to the tumor. Therefore, anti-angiogenic therapy, particularly anti-VEGF and anti-VEGF receptor (VEGFR) therapy, has been a popular strategy to treat cancer. However, anti-angiogenic therapy does not signifi...

journal_title：OncoTargets and therapy

authors： Tian W,Cao C,Shu L,Wu F

更新日期：2020-11-24 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：Background:The global Phase III LUX-Lung 8 trial (ClinicalTrials.gov: NCT01523587) identified significant improvements in progression-free survival (PFS), overall survival (OS), and patient-reported outcomes (PROs) with second-line afatinib vs erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lun...

journal_title：OncoTargets and therapy

authors： Lu S,Li W,Zhou C,Hu CP,Qin S,Cheng G,Feng J,Wang J,Cseh A,Peil B,Gibson N,Ehrnrooth E,Zhang L

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:C-X-C chemokine receptor type 4 (CXCR4) is involved in tumor progression including angiogenesis, metastasis, and survival. However, whether serum CXCR4 levels in metastatic or recurrent colorectal cancer have a prognostic role, have not been evaluated. METHODS:We analyzed serum samples from 55 patients with...

journal_title：OncoTargets and therapy

authors： Choi YJ,Chang WJ,Shin SW,Park KH,Kim ST,Kim YH

更新日期：2016-06-01 00:00:00

abstract：:Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related meta...

journal_title：OncoTargets and therapy

authors： Salman P,Panay S,Fernández R,Mahave M,Soza-Ried C

更新日期：2018-10-23 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：Purposes:The main aim of the study was to investigate the dosimetric difference between acuros XB algorithm (AXB), anisotropic analytic algorithm (AAA), and pencil beam convolution (PBC) algorithm in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC). Patients and Methods:Thirty-eig...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang D,Su H,Dai Z,Dai J,Liu H,Xie C,Yu H

更新日期：2019-08-12 00:00:00