MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4.

abstract：:Glioma is the most common and aggressive human primary tumor in the central nervous system. Despite present clinical advancements, median survival time remains poor in this malignant tumor. Serpin peptidase inhibitor, clade A member 3 (SERPINA3), is a member of the serpin superfamily of protease inhibitors. Its aberra...

journal_title：OncoTargets and therapy

authors： Luo D,Chen W,Tian Y,Li J,Xu X,Chen C,Li F

更新日期：2017-04-18 00:00:00

abstract：Background:Previous reports show that SIRT6 serves as a critical modulator of the development of multiple malignancies as well as other disorders. However, its role in nasopharyngeal carcinoma (NPC) is unknown. Thus, we elucidated the effects of SIRT6 on the survival of NPC cells, and modulation of cell death. Methods...

journal_title：OncoTargets and therapy

authors： Ouyang L,Yi L,Li J,Yi S,Li S,Liu P,Yang X

更新日期：2018-11-01 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...

journal_title：OncoTargets and therapy

authors： Wang W,Wang J,Zhang X,Liu G

更新日期：2019-09-11 00:00:00

abstract：Objective:The biological functions and molecular mechanisms of miR-935 have been widely investigated in various types of cancer. The aim of the present study was to explore the function of miR-935 in glioma. Methods:Bioinformatic analysis and quantitative real-time fluorescent PCR (qRT-PCR) were used to determine the ...

journal_title：OncoTargets and therapy

authors： Huang G,Chen J,Liu J,Zhang X,Duan H,Fang Q

更新日期：2020-10-23 00:00:00

abstract：:The fusion of echinoderm microtubule-associated protein-like 4 with anaplastic lymphoma kinase (ALK) was identified as a transforming gene for lung cancer in 2007. This genetic rearrangement accounts for 2%-5% of non-small-cell lung cancer (NSCLC) cases, occurring predominantly in younger individuals with adenocarcino...

journal_title：OncoTargets and therapy

authors： Iwama E,Okamoto I,Harada T,Takayama K,Nakanishi Y

更新日期：2014-03-05 00:00:00

abstract：Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...

journal_title：OncoTargets and therapy

authors： Wang D,Xiang Y,Wu M,Shen K,Yang J,Huang H,Ren T

更新日期：2018-03-07 00:00:00

abstract：:Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...

journal_title：OncoTargets and therapy

authors： Li F,Huang Q,Gong Z,Wang H,Chen J

更新日期：2019-05-31 00:00:00

abstract：Objective:Growing epidemiological evidence supports that coagulation cascades and cancer-associated inflammation are associated with recurrence and survival of epithelial ovarian cancer (EOC). This study aimed to assess the clinical significance of the combination of plasm fibrinogen and neutrophil lymphocyte ratio (F-...

journal_title：OncoTargets and therapy

authors： Yang J,Ma J,Cheng S,Wang Y

更新日期：2020-07-27 00:00:00

abstract：Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...

journal_title：OncoTargets and therapy

authors： Wang H,Feng L,Zheng Y,Li W,Liu L,Xie S,Zhou Y,Chen C,Cheng D

更新日期：2020-08-18 00:00:00

abstract：:Background: Previous studies have reported that the albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker-based index, is associated with clinical outcome in several cancers. However, data relating to lung cancer are rare. This study was performed to clarify the clinical significance of AAPR in patient...

journal_title：OncoTargets and therapy

authors： Li D,Yu H,Li W

更新日期：2019-07-02 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...

journal_title：OncoTargets and therapy

authors： Wu SG,Sun JY,Zhou J,Li FY,Lin Q,Lin HX,He ZY

更新日期：2014-02-15 00:00:00

abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：Introduction:Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tum...

journal_title：OncoTargets and therapy

authors： Lu Q,Wang X,Zhu J,Fei X,Chen H,Li C

更新日期：2020-11-18 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00

abstract：Objective:As an epidermal growth factor, receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib demonstrates a good therapeutic effect in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). However, an overwhelming majority of these patients inevitably develop resistance against gefitinib. Unfortunately, th...

journal_title：OncoTargets and therapy

authors： Zhang D,Han LL,Du F,Liu XM,Li J,Wang HH,Song MH,Li Z,Li GY

更新日期：2019-11-18 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00

abstract：Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...

journal_title：OncoTargets and therapy

authors： Li C,Li W,Zhang Y,Zhang X,Liu T,Zhang Y,Yang Y,Wang L,Pan H,Ji J,Wang C

更新日期：2018-07-10 00:00:00

abstract：Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang H,Xu D,Wu WJ,Chen HD,He L

更新日期：2019-11-07 00:00:00

abstract：Background and aim:Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with n...

journal_title：OncoTargets and therapy

authors： Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR

更新日期：2017-11-10 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...

journal_title：OncoTargets and therapy

authors： Zong M,Jia L,Li L

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...

journal_title：OncoTargets and therapy

authors： Hu QC,Mei X,Feng Y,Ma JL,Yang ZZ,Shao ZM,Yu XL,Guo XM

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：:Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). The...

journal_title：OncoTargets and therapy

authors： Martin JM,Goldstein LJ

更新日期：2018-08-29 00:00:00

abstract：:The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...

journal_title：OncoTargets and therapy

authors： Sun Y,Tao C,Huang X,He H,Shi H,Zhang Q,Wu H

更新日期：2016-05-12 00:00:00

abstract：Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...

journal_title：OncoTargets and therapy

authors： Bimonte S,Barbieri A,Cascella M,Rea D,Palma G,Del Vecchio V,Forte CA,Del Prato F,Arra C,Cuomo A

更新日期：2018-01-03 00:00:00