Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China.

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...

journal_title：OncoTargets and therapy

authors： Zhong G,Lin Y,Wang X,Wang K,Liu J,Wei W

更新日期：2020-12-07 00:00:00

abstract：Background:Mounting evidences reveal that circular RNAs (circRNAs) are critical to regulate biological behavior and process of tumor. Our objective is to explore the role of circRNA-PTN (circPTN) and explain the exact mechanism in hepatocellular carcinoma (HCC). Methods:Real-time polymerase chain reaction assay was us...

journal_title：OncoTargets and therapy

authors： Jia B,Yin X,Wang Y,Qian J,He Y,Yang C,Yu G,Guo B,Meng X

更新日期：2020-05-29 00:00:00

abstract：Introduction:Cervical cancer, one of the most common malignant gynecological tumors, is a significant burden on the health of females worldwide. The purpose of this study was to investigate genes associated with lymph node metastasis in cervical cancer. Methods:We report on the lymph node metastasis-associated gene, s...

journal_title：OncoTargets and therapy

authors： Jia Y,Li H,Liu G,Song F

更新日期：2018-10-15 00:00:00

abstract：Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...

journal_title：OncoTargets and therapy

authors： Wang H,Feng L,Zheng Y,Li W,Liu L,Xie S,Zhou Y,Chen C,Cheng D

更新日期：2020-08-18 00:00:00

abstract：Objective:Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA highly upregulated in liver cancer (HULC) has been identified as a key regulator in the progression of various cancers. However, the functional role and the mechanisms of HULC in regulating cervical cancer cell b...

journal_title：OncoTargets and therapy

authors： Lu W,Wan X,Tao L,Wan J

更新日期：2020-02-05 00:00:00

abstract：Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...

journal_title：OncoTargets and therapy

authors： Cheng LC,Chao YJ,Wang CY,Phan NN,Chen YL,Wang TW,Hsu HP,Lin YJ,Shan YS,Lai MD

更新日期：2020-08-03 00:00:00

abstract：:Esophageal carcinoma (EC) is a lethal disease with high morbidity and mortality worldwide, and the incidence has been increasing in recent years. Although the diagnosis and treatment of EC have improved considerably, EC has rapidly progressed in the clinical setting and has a poor prognosis for its metastasis and recu...

journal_title：OncoTargets and therapy

authors： Qian X,Tan C,Wang F,Yang B,Ge Y,Guan Z,Cai J

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Lapatinib is a dual epidermal growth factor receptor (EGFR) and HER2 inhibitor. Overexpression of these receptors is frequently observed in head and neck squamous cell carcinoma (HNSCC). As growing proportion of HNSCC is characterized by human papillomavirus (HPV) infection, we aimed at evaluating the effica...

journal_title：OncoTargets and therapy

authors： Fumagalli I,Dugue D,Bibault JE,Clémenson C,Vozenin MC,Mondini M,Deutsch E

更新日期：2015-02-02 00:00:00

abstract：INTRODUCTION:To investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate. METHODS:The clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical exami...

journal_title：OncoTargets and therapy

authors： Sha J,Bo J,Pan J,Zhang L,Xuan H,Chen W,Li D,Wang Z,Liu D,Huang Y

更新日期：2013-10-24 00:00:00

abstract：Background:Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics and toxic compounds including (pro)carcinogens. BCRP is expressed in many tissues, including...

journal_title：OncoTargets and therapy

authors： Niebudek K,Balcerczak E,Mirowski M,Pietrzak J,Zawadzka I,Żebrowska-Nawrocka M

更新日期：2019-02-27 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...

journal_title：OncoTargets and therapy

authors： Tang D,Liu CY,Shen D,Fan S,Su X,Ye P,Gavine PR,Yin X

更新日期：2014-12-16 00:00:00

abstract：Purpose:Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX. Methods:Microarray analysis was used to identify differentially expressed genes in pacl...

journal_title：OncoTargets and therapy

authors： Guo M,Li S,Zhao X,Yuan Y,Zhang B,Guan Y

更新日期：2020-12-24 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...

journal_title：OncoTargets and therapy

authors： Chen P,Song Q,Han J,Xu H,Chen T,Xu J,Cheng Y

更新日期：2017-09-27 00:00:00

abstract：:Ocular sebaceous carcinoma (SC) is an exceedingly rare but aggressive malignancy that can impair patients' visual acuity or even cause tumor-specific mortality. This tumor usually mimics chronic benign eyelid lesions, thus leading to delayed diagnosis, thereby causing high recurrence and metastasis. Ophthalmologists s...

journal_title：OncoTargets and therapy

authors： Xu Y,Li F,Jia R,Fan X

更新日期：2018-06-27 00:00:00

abstract：:Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...

journal_title：OncoTargets and therapy

authors： Rösel D,Brábek J,Veselý P,Fernandes M

更新日期：2013-06-26 00:00:00

abstract：BACKGROUND:According to the relevant reports, TIMP-2 polymorphism might be associated with the susceptibility to gastric cancer. Owing to the inconclusive results from the published studies based on the association between TIMP-2 single nucleotide polymorphisms (SNPs) and gastric cancer susceptibility, a meta-analysis ...

journal_title：OncoTargets and therapy

authors： Yang Y,Xiong Y,Li J,Wu C,Jiang J

更新日期：2016-11-03 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL), which belong to the family of Argonaute genes/proteins, bind to piRNAs and function mainly in germ line cells, but...

journal_title：OncoTargets and therapy

authors： Iliev R,Stanik M,Fedorko M,Poprach A,Vychytilova-Faltejskova P,Slaba K,Svoboda M,Fabian P,Pacik D,Dolezel J,Slaby O

更新日期：2016-01-08 00:00:00

abstract：:Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic the...

journal_title：OncoTargets and therapy

authors： Tysome JR,Lemoine NR,Wang Y

更新日期：2013-07-31 00:00:00

abstract：:High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metasta...

journal_title：OncoTargets and therapy

authors： Na N,Si T,Huang Z,Miao B,Hong L,Li H,Qiu J,Qiu J

更新日期：2016-11-22 00:00:00

abstract：Purpose:Minimally invasive esophagectomy is increasingly performed for esophageal or gastroesophageal junctional cancer, with advantages of improved perioperative outcomes in comparison with open esophagectomy. McKeown and Ivor Lewis are widely used procedures of minimally invasive esophagectomy, and there have been co...

journal_title：OncoTargets and therapy

authors： Deng J,Su Q,Ren Z,Wen J,Xue Z,Zhang L,Chu X

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Repetitive genotyping is useful to assess the genetic evolution of non-small-cell lung cancer (NSCLC) during treatment, but the need for sampling by biopsy is a major obstacle. Digital polymerase chain reaction (PCR) is a promising procedure for the detection of mutant alleles in plasma of cancer patients. ...

journal_title：OncoTargets and therapy

authors： Nakahara Y,Takagi Y,Hosomi Y,Kagei A,Yamamoto T,Sawada T,Yomota M,Okuma Y,Mikura S,Okamura T

更新日期：2016-08-24 00:00:00

abstract：INTRODUCTION:The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung cancer (NSCLC) with EGFR+ mutations. However, most patients develop resistance, with the result that median progression-free survival (PFS) iŝ1...

journal_title：OncoTargets and therapy

authors： Batson S,Mitchell SA,Windisch R,Damonte E,Munk VC,Reguart N

更新日期：2017-05-05 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...

journal_title：OncoTargets and therapy

authors： Xie M,Cai L,Li J,Zhao J,Guo Y,Hou Z,Zhang X,Tian H,Li A,Miao Y

更新日期：2020-05-19 00:00:00

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：:Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The...

journal_title：OncoTargets and therapy

authors： Tarazona N,Navarro L,Cejalvo JM,Gambardella V,Pérez-Fidalgo JA,Sempere A,Navarro S,Cervantes A

更新日期：2015-05-14 00:00:00

abstract：Objective:Long non-coding RNA (lncRNA) ANRIL is emerging as a crucial role in ovarian cancer progression and prognosis. However, the precise molecular mechanism of ANRIL on ovarian cancer is not known. Thus, we aim to study the underlying mechanism of ANRIL on the action. Methods:The MTT assay assessed cell viability....

journal_title：OncoTargets and therapy

authors： Wang K,Hu YB,Zhao Y,Ye C

更新日期：2021-01-19 00:00:00