Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature.

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：Introduction:Cervical cancer, one of the most common malignant gynecological tumors, is a significant burden on the health of females worldwide. The purpose of this study was to investigate genes associated with lymph node metastasis in cervical cancer. Methods:We report on the lymph node metastasis-associated gene, s...

journal_title：OncoTargets and therapy

authors： Jia Y,Li H,Liu G,Song F

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...

journal_title：OncoTargets and therapy

authors： Van Pham P,Vu NB,Duong TT,Nguyen TT,Truong NH,Phan NL,Vuong TG,Pham VQ,Nguyen HM,Nguyen KT,Nguyen NT,Nguyen KG,Khat LT,Van Le D,Truong KD,Phan NK

更新日期：2012-01-01 00:00:00

abstract：:The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathological...

journal_title：OncoTargets and therapy

authors： Zhuang PH,Xu L,Gao L,Lu W,Ruan LT,Yang J

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Lapatinib is a dual epidermal growth factor receptor (EGFR) and HER2 inhibitor. Overexpression of these receptors is frequently observed in head and neck squamous cell carcinoma (HNSCC). As growing proportion of HNSCC is characterized by human papillomavirus (HPV) infection, we aimed at evaluating the effica...

journal_title：OncoTargets and therapy

authors： Fumagalli I,Dugue D,Bibault JE,Clémenson C,Vozenin MC,Mondini M,Deutsch E

更新日期：2015-02-02 00:00:00

abstract：Purpose:miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated. Methods:Bioinformatics was used to analyze the target genes of miR-497-5p. qRT-PCR and Western blot were used to analyze mRNA and protein expression, respectively. Dual-luciferase reporter ass...

journal_title：OncoTargets and therapy

authors： Chen Y,Du J,Wang Y,Shi H,Jiang Q,Wang Y,Zhang H,Wei Y,Xue W,Pu Z,Gao Y,Li D,Feng Y,Yan J,Zhang J

更新日期：2019-12-02 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...

journal_title：OncoTargets and therapy

authors： Zhong G,Lin Y,Wang X,Wang K,Liu J,Wei W

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...

journal_title：OncoTargets and therapy

authors： Wang H,Yu J,Li L

更新日期：2015-10-23 00:00:00

abstract：Aim:This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods:A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant ch...

journal_title：OncoTargets and therapy

authors： Zhao H,He Y,Yang SL,Zhao Q,Wu YM

更新日期：2019-03-07 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods:Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, m...

journal_title：OncoTargets and therapy

authors： Li L,Wan K,Xiong L,Liang S,Tou F,Guo S

更新日期：2020-04-03 00:00:00

abstract：Background:The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progressio...

journal_title：OncoTargets and therapy

authors： Jin Y,Xie H,Duan L,Zhao D,Ding J,Jiang G

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...

journal_title：OncoTargets and therapy

authors： Halpern N,Goldberg Y,Kadouri L,Duvdevani M,Hamburger T,Peretz T,Hubert A

更新日期：2017-03-29 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：:Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...

journal_title：OncoTargets and therapy

authors： Wang G,Jing Y,Cao L,Gong C,Gong Z,Cao X

更新日期：2016-12-20 00:00:00

abstract：Background:LncRNA LINC00461 has been reported to play crucial regulatory roles in a variety of biological processes, including cell migration, cell invasion and cancer progression. However, its biological role in colorectal cancer (CRC) is completely unknown. The aim of our study was to explore the function of LINC0046...

journal_title：OncoTargets and therapy

authors： Yu H,Ma J,Chen J,Yang Y,Liang J,Liang Y

更新日期：2019-12-17 00:00:00

abstract：Background and aim:Ewing sarcoma (ES) is an aggressive neoplasm predominantly occurring in adolescents and has a poor prognosis when metastasized. In the current study, we were aiming to investigate the function of TRIM3 in autophagy in ES cells. Methods:The expression of TRIM3 in Ewing sarcoma tissues and normal tiss...

journal_title：OncoTargets and therapy

authors： Lu Q,Zhang Y,Ma L,Li D,Li M,Liu P,Li J

更新日期：2019-12-30 00:00:00

abstract：OBJECTIVE:To evaluate efficacy and safety of nimotuzumab combined with chemotherapy and radiotherapy in women with locally advanced cervical cancer. MATERIALS AND METHODS:Women with locally advanced cervical cancer (stage IIB, III, or IVA) who experienced relapse after first-line chemoradiotherapy and one or more line...

journal_title：OncoTargets and therapy

authors： Chen YF,Tang WB,Pan XX,Wu CR,Cao Y,Yang W

更新日期：2017-08-17 00:00:00

abstract：Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...

journal_title：OncoTargets and therapy

authors： Xie M,Cai L,Li J,Zhao J,Guo Y,Hou Z,Zhang X,Tian H,Li A,Miao Y

更新日期：2020-05-19 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor tyrosine kinases. Particularly, FGFR2 has been identified as a potential target for tyrosine kinase inhibitor (TKI) treatment. Except for immunohistochemistry and fluorescence in situ hybridization, next-generation sequencing (NGS)...

journal_title：OncoTargets and therapy

authors： Ying X,Tu J,Wang W,Li X,Xu C,Ji J

更新日期：2019-11-06 00:00:00

abstract：:Aberrant methylation of CpG dinucleotides is a commonly observed epigenetic modification in human cancer. Thus, detection of aberrant gene promoter methylation as a tool for diagnosis of tumors or as a prognostic marker has been widely described for many types of cancers, including nonsmall cell lung cancer (NSCLC). E...

journal_title：OncoTargets and therapy

authors： Xue R,Yang C,Zhao F,Li D

更新日期：2014-10-31 00:00:00

abstract：Purpose:Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging ar...

journal_title：OncoTargets and therapy

authors： Boogerd LS,van der Valk MJ,Boonstra MC,Prevoo HA,Hilling DE,van de Velde CJ,Sier CF,Fariña Sarasqueta A,Vahrmeijer AL

更新日期：2018-03-23 00:00:00

abstract：Background:This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Materials and methods:MCF-7 cells tr...

journal_title：OncoTargets and therapy

authors： Ying Zhi L,Xu Z,Ning L,Jia Jin L,Hai Cui Y,Hong HG,Fang XJ

更新日期：2018-09-10 00:00:00

abstract：Objective:Sanguinarine (SNG) is a benzophenanthridine alkaloid obtained from the roots of Sanguinaria canadensis and has an anticancer effect. The aim of this study was to explore the mechanism of SNG in inhibiting macrophages via regulating the exosomes derived from lung carcinoma cells to reduce metastasis and prolif...

journal_title：OncoTargets and therapy

authors： Yu Y,Luo Y,Fang Z,Teng W,Yu Y,Tian J,Guo P,Xu R,Wu J,Li Y

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the o...

journal_title：OncoTargets and therapy

authors： Powles T,McFaul S,Stebbing J,Wilson P,Oliver T,Tranter N,Shamash J

更新日期：2008-09-01 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：OBJECTIVE:Despite advances in the early diagnosis of gastrointestinal (GI) cancers, these cancers are often being detected rather late in their course. Emerging published data on the accuracy of dickkopf-1 (DKK1) for diagnosing GI cancers are inconsistent. The purpose of this systematic review and meta-analysis was to ...

journal_title：OncoTargets and therapy

authors： Liang B,Zhong L,He Q,Wang S,Pan Z,Wang T,Zhao Y

更新日期：2015-10-22 00:00:00

abstract：Background:This study was designed to research the potential function of lncRNA ANRIL in osteosarcoma (OS). Materials and methods:Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out. Results:ANRIL...

journal_title：OncoTargets and therapy

authors： Guan H,Mei Y,Mi Y,Li C,Sun X,Zhao X,Liu J,Cao W,Li Y,Wang Y

更新日期：2018-08-14 00:00:00

abstract：Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...

journal_title：OncoTargets and therapy

authors： Soleymani Fard S,Yazdanbod M,Sotoudeh M,Bashash D,Mahmoodzadeh H,Saliminejad K,Mousavi SA,Ghaffari SH,Alimoghaddam K

更新日期：2020-10-02 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00