Abstract:
:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are related to the clinicopathological characteristics, prognosis, and chemosensitivity of BC, and basic research has further confirmed that changes in the expression of circRNAs in BC are closely related to various tumor biological functions. CircRNAs promote tumor development by interacting with miRNAs to regulate transcription factors and both classical and nonclassical tumor signaling pathways. The nonclassical signaling pathways are related to cell cycle progression, epithelial-mesenchymal transition (EMT), extracellular matrix maintenance, and tumor stem cell maintenance. In this article, the relationships between circRNAs and the clinical characteristics of BC are reviewed, and the molecular mechanisms by which circRNAs promote tumor development are explored.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Cai Z,Li Hdoi
10.2147/OTT.S268859subject
Has Abstractpub_date
2020-09-29 00:00:00pages
9573-9586issn
1178-6930pii
268859journal_volume
13pub_type
杂志文章,评审abstract::Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S177111
更新日期:2018-12-04 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S214060.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S258499
更新日期:2020-05-26 00:00:00
abstract:Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219429
更新日期:2019-09-23 00:00:00
abstract::Recently, "ipilimumab," an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. "CTLA-4" is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is able to remove the CTL...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S57335
更新日期:2014-02-19 00:00:00
abstract::Lung cancer has the highest morbidity and mortality in the world, and non-small cell lung carcinomas (NSCLC) account for 80% of cases of lung cancer. The mechanism of NSCLC is still largely unknown, and finding novel targets is of great importance for the treatment of NSCLC. The current study was designed to evaluate ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S123518
更新日期:2017-03-02 00:00:00
abstract:Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S163883
更新日期:2018-07-10 00:00:00
abstract::[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S139588
更新日期:2017-04-27 00:00:00
abstract::Whether the addition of induction chemotherapy (IC) or adjuvant chemotherapy (AC) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locally advanced nasopharyngeal cancer is unknown. A Bayesian network meta-analysis was performed to investigate the efficacy of CCRT, IC + CCRT, and CCRT + AC on local...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S96983
更新日期:2016-01-05 00:00:00
abstract:Purpose:Breast cancer (BC) is the most common malignant cancer in women worldwide. Recently, long non-coding RNAs (LncRNAs) have been reported to have essential roles in BC tumorigenesis. Patients and Methods:Tumor and adjacent non-tumor tissue samples were collected from patients with BC (n = 168) for comparison of L...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247776
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S54575
更新日期:2013-12-18 00:00:00
abstract:Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S256818
更新日期:2020-07-03 00:00:00
abstract:Background:Deleted in breast cancer 1 (DBC1) is believed to be involved in human cancers. However, it is still uncertain whether DBC1 expression can be regarded as a prognostic factor in patients with various cancers. This meta-analysis aimed to evaluate the relationship between high levels of DBC1 and prognosis in tum...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S189618
更新日期:2019-02-22 00:00:00
abstract:Background:Erlotinib is a commonly used molecular-targeted drug for the treatment of tongue cancer. However, the development of acquired resistance to erlotinib hampers its therapeutic use. Materials and methods:To analyze the erlotinib resistance, long-term and short term survival assay were used to compare the resis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S167936
更新日期:2018-09-05 00:00:00
abstract:Background:The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progressio...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S226078
更新日期:2019-10-31 00:00:00
abstract::The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87159
更新日期:2015-09-14 00:00:00
abstract:Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176511
更新日期:2018-10-02 00:00:00
abstract:PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S69239
更新日期:2014-09-30 00:00:00
abstract:BACKGROUND:Paxillin is implicated in tumorigenesis, progression and aggressive phenotypes of various malignancies, highlighting its functions in cellular adhesion, migration and survival. However, the roles of paxillin in human gliomas remain unclear. The aim of this study was to evaluate the clinical implication of pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S114229
更新日期:2016-11-09 00:00:00
abstract:Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S205017
更新日期:2019-11-07 00:00:00
abstract::Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of d...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S106926
更新日期:2016-08-08 00:00:00
abstract:Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247393
更新日期:2020-06-25 00:00:00
abstract::This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic castration-resistant prostate cancer (CRPC). RNA was analyzed in blood from six CRPC patients by whole-transcriptome sequencing (total RNA-sequencing) before and after docetaxel ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86637
更新日期:2015-07-30 00:00:00
abstract:Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S158259
更新日期:2018-07-19 00:00:00
abstract::Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S227156
更新日期:2019-12-27 00:00:00
abstract:Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S194745
更新日期:2019-03-25 00:00:00
abstract::Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S184303
更新日期:2018-11-05 00:00:00
abstract::Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL), which belong to the family of Argonaute genes/proteins, bind to piRNAs and function mainly in germ line cells, but...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S91295
更新日期:2016-01-08 00:00:00
abstract:Background:As a component of the EIF3 complex, EIF3C is essential for several steps in protein synthesis initiation. Recently, it has been addressed that EIF3C is overexpressed in several human cancers and plays a pivotal role in cell proliferation and tumorigenesis. Materials and methods:Immunohistochemistry, quantit...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S187209
更新日期:2019-02-14 00:00:00
abstract:Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S165368
更新日期:2018-10-26 00:00:00
abstract:BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92314
更新日期:2015-12-17 00:00:00