Promoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer.

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：Background:The non-receptor tyrosine kinase Fyn-related kinase (FRK) has been reported to affect cell proliferation in several cancer types. However, its effect on the proliferation of clear cell renal cell carcinoma (ccRCC) remains largely unknown. Purpose:The objective of this study was to investigate the expression...

journal_title：OncoTargets and therapy

authors： Jing ZF,Bi JB,Li ZL,Liu XK,Li J,Zhu YY,Zhang XT,Zhang Z,Li ZH,Kong CZ

更新日期：2019-04-10 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：Background:PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-relat...

journal_title：OncoTargets and therapy

authors： He W,Zhang X,Li W,Kong C,Wang Y,Zhu L,Xu R,Deng G,Zhang P

更新日期：2018-10-24 00:00:00

abstract：Background:KIF18B was identified as a potential oncogene by analysis of The Cancer Genome Atlas database. Materials and methods:We assessed KIF18B expression and explored its clinical significance in cervical cancer tissues. We have also evaluated the effects of KIF18B on cervical cancer cell proliferation, migration,...

journal_title：OncoTargets and therapy

authors： Wu Y,Wang A,Zhu B,Huang J,Lu E,Xu H,Xia W,Dong G,Jiang F,Xu L

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS:A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy...

journal_title：OncoTargets and therapy

authors： Joo JH,Kim YJ,Kim YS,Cho YP,Lee HY,Jeong CY,Kwak J,Cho BC

更新日期：2016-05-24 00:00:00

abstract：:Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...

journal_title：OncoTargets and therapy

authors： Song XY,Li BY,Zhou EX,Wu FX

更新日期：2016-08-26 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：:Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...

journal_title：OncoTargets and therapy

authors： Yan Y,Grothey A

更新日期：2015-10-15 00:00:00

abstract：Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C p...

journal_title：OncoTargets and therapy

authors： Liu Y,Meng Y,Wang L,Liu Z,Li J,Dong W

更新日期：2018-11-23 00:00:00

abstract：AIM:The aim of this study was to assess if the expression of Notch 1 receptor is associated with tumor aggressiveness in papillary thyroid carcinomas (PTCs). PATIENTS AND METHODS:By searching the electronic medical record system of Xin Hua Hospital, all cases of PTC patients who underwent thyroidectomy in the hospital...

journal_title：OncoTargets and therapy

authors： Fu H,Ma C,Guan W,Cheng W,Feng F,Wang H

更新日期：2016-03-15 00:00:00

abstract：Purpose:Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellul...

journal_title：OncoTargets and therapy

authors： Shi S,Zheng G,Yang C,Chen X,Yan Q,Jiang F,Jiang X,Xin Y,Jiang G

更新日期：2019-12-31 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：Background:Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer...

journal_title：OncoTargets and therapy

authors： Zou YF,Rong YM,Chen ZX,Shen ZH,Chen X,Tan YX,Weng JR,Huang XM,Lin XT

更新日期：2020-08-26 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：Purpose:Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have...

journal_title：OncoTargets and therapy

authors： Yang S,Wang M,Yang L,Li Y,Ma Y,Peng X,Li X,Li B,Jin H,Li H

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that the clock gene PER1 regulates various tumor-related genes. Abnormal expressions and circadian rhythm alterations of PER1 are closely related to carcinogenesis. However, the dynamic circadian variations of PER1 and tumor-related genes at different stages of carcinogenesis...

journal_title：OncoTargets and therapy

authors： Ye H,Yang K,Tan XM,Fu XJ,Li HX

更新日期：2015-06-11 00:00:00

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：Purpose:Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX. Methods:Microarray analysis was used to identify differentially expressed genes in pacl...

journal_title：OncoTargets and therapy

authors： Guo M,Li S,Zhao X,Yuan Y,Zhang B,Guan Y

更新日期：2020-12-24 00:00:00

abstract：INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...

journal_title：OncoTargets and therapy

authors： Sun P,Chen C,Zhang F,Yang H,Bi XW,An X,Wang FH,Jiang WQ

更新日期：2016-07-13 00:00:00

abstract：Background:This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Materials and methods:MCF-7 cells tr...

journal_title：OncoTargets and therapy

authors： Ying Zhi L,Xu Z,Ning L,Jia Jin L,Hai Cui Y,Hong HG,Fang XJ

更新日期：2018-09-10 00:00:00

abstract：Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...

journal_title：OncoTargets and therapy

authors： Pan G,Ma Y,Suo J,Li W,Zhang Y,Qin S,Jiao Y,Zhang S,Li S,Kong Y,Du Y,Gao S,Wang D

更新日期：2020-07-27 00:00:00

abstract：Background:Investigating the roles of lncRNA prostate cancer-associated transcript 6 (PCAT6) in modulating the growth and aggressiveness of non-small-cell lung carcinoma (NSCLC) cell. Method:The levels of PCAT6 in NSCLC tissues and cell lines were determined by quantitative real-time PCR assay. MTT as well as colony f...

journal_title：OncoTargets and therapy

authors： Cui LH,Xu HR,Yang W,Yu LJ

更新日期：2018-11-01 00:00:00

abstract：:Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value in clinical application. Purpose: Herein, we reported MCL-1 expression patte...

journal_title：OncoTargets and therapy

authors： Li XX,Zhou JD,Wen XM,Zhang TJ,Wu DH,Deng ZQ,Zhang ZH,Lian XY,He PF,Yao XY,Lin J,Qian J

更新日期：2019-05-01 00:00:00

abstract：:Circulating tumor cells (CTCs) possess profound influence on tumor metastases and disease progression. This study aimed to investigate the correlation of CTCs with clinical characteristics and T-cell immunity, and to explore whether CTCs and the subpopulations can serve as an independent prognostic factor in advanced ...

journal_title：OncoTargets and therapy

authors： Sun WW,Xu ZH,Lian P,Gao BL,Hu JA

更新日期：2017-05-04 00:00:00

abstract：PURPOSE:This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS:A prospective, open-label, single-arm Phase II study (Clinical...

journal_title：OncoTargets and therapy

authors： Wang J,Tian Y,Tang Y,Wang X,Li N,Ren H,Fang H,Feng Y,Wang S,Song Y,Liu Y,Wang W,Li Y,Jin J

更新日期：2016-05-05 00:00:00

abstract：Background:miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective:This study aimed to analyze the expression profile of miR-486-5p in tumor ti...

journal_title：OncoTargets and therapy

authors： Zheng X,Xu K,Zhu L,Mao M,Zhang F,Cui L

更新日期：2020-05-28 00:00:00

abstract：Background:New evidence suggests that histidine triad nucleotide-binding protein 1 (Hint1) exerts a tumor suppressor effect in various human tumors, such as colorectal cancer and gastric cancer. However, it has not been reported whether Hint1 is involved in the occurrence and development of osteosarcoma (OS). Material...

journal_title：OncoTargets and therapy

authors： Duan DD,Xie H,Shi HF,Huang WW,Ding F,Hong JK,Fan JS,Hu SY,Wang QW,Zhou MQ

更新日期：2020-08-19 00:00:00