KIF18B promotes tumor progression through activating the Wnt/β-catenin pathway in cervical cancer.

abstract：Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...

journal_title：OncoTargets and therapy

authors： Li C,Li W,Zhang Y,Zhang X,Liu T,Zhang Y,Yang Y,Wang L,Pan H,Ji J,Wang C

更新日期：2018-07-10 00:00:00

abstract：Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...

journal_title：OncoTargets and therapy

authors： Xie M,Cai L,Li J,Zhao J,Guo Y,Hou Z,Zhang X,Tian H,Li A,Miao Y

更新日期：2020-05-19 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:Stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR) has been reported to be a comparable alternative therapy to surgery for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). However, it has not been clarified whether SBRT/SABR is as effective as surgery. We conducted t...

journal_title：OncoTargets and therapy

authors： Li M,Yang X,Chen Y,Yang X,Dai X,Sun F,Zhang L,Zhan C,Feng M,Wang Q

更新日期：2017-06-07 00:00:00

abstract：Purpose:This study aimed to explore significant genes and pathways involved in the pathogenesis of supratentorial primitive neuroectodermal tumor (sPNET). Materials and methods:Gene expression profile of GSE14295 was downloaded from publicly available Gene Expression Omnibus (GEO) database. Differentially expressed ge...

journal_title：OncoTargets and therapy

authors： Wang GY,Li L,Liu B,Han X,Wang CH,Wang JW

更新日期：2018-04-04 00:00:00

abstract：:Ocular sebaceous carcinoma (SC) is an exceedingly rare but aggressive malignancy that can impair patients' visual acuity or even cause tumor-specific mortality. This tumor usually mimics chronic benign eyelid lesions, thus leading to delayed diagnosis, thereby causing high recurrence and metastasis. Ophthalmologists s...

journal_title：OncoTargets and therapy

authors： Xu Y,Li F,Jia R,Fan X

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Several studies have reported an association between the A23G polymorphism (rs 1800975) in the xeroderma pigmentosum group A (XPA) gene and risk of digestive system cancers. However, the results are inconsistent. In this study, we performed a meta-analysis to assess the association between XPA A23G polymorph...

journal_title：OncoTargets and therapy

authors： He L,Deng T,Luo H

更新日期：2015-02-05 00:00:00

abstract：PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...

journal_title：OncoTargets and therapy

authors： Qiao GL,Qi WX,Jiang WH,Chen Y,Ma LJ

更新日期：2016-03-31 00:00:00

abstract：PURPOSE:Subsets of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon subtypes. We evaluated the efficacy of first-generation EGFR-tyrosine kinase inhibitors (TKIs; erlotinib, gefitinib, and icotinib) in patients with non-small-cell lung cancer carrying insertions ...

journal_title：OncoTargets and therapy

authors： Chen D,Song Z,Cheng G

更新日期：2016-07-08 00:00:00

abstract：Purpose:Paclitaxel resistance in ovarian cancer has become an urgent clinical problem. This study investigated the regulatory effects of RAB17 on the non-coding RNA network of the paclitaxel-resistant ovarian cancer cell A2780/PTX. Methods:Microarray analysis was used to identify differentially expressed genes in pacl...

journal_title：OncoTargets and therapy

authors： Guo M,Li S,Zhao X,Yuan Y,Zhang B,Guan Y

更新日期：2020-12-24 00:00:00

abstract：Background:Several intracellular signaling pathways that are deregulated during hepatocarcinogenesis might constitute potential targets for hepatocellular carcinoma (HCC) therapy. The aim of this study was to test the potential synergic antitumor effect of salirasib and sorafenib in a diethylnitrosamine (DEN)-induced H...

journal_title：OncoTargets and therapy

authors： Ciccarelli O,Colson A,De Saeger C,Reding R,Sempoux C,Leclercq IA,Stärkel P

更新日期：2018-10-17 00:00:00

abstract：:Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of the cell membrane in various immune cells, such as dendritic c...

journal_title：OncoTargets and therapy

authors： Zhu P,Hu C,Hui K,Jiang X

更新日期：2017-09-01 00:00:00

abstract：Aim:This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods:A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant ch...

journal_title：OncoTargets and therapy

authors： Zhao H,He Y,Yang SL,Zhao Q,Wu YM

更新日期：2019-03-07 00:00:00

abstract：:We report the case of a man with an advanced nonkeratinizing squamous cell thymic carcinoma harboring c-KIT exon 13 missense mutation K642E. This aberration is rare and has never been described previously in patients with thymic cancers. It has been found in a small number of cases of gastrointestinal stromal tumor an...

journal_title：OncoTargets and therapy

authors： Catania C,Conforti F,Spitaleri G,Barberis M,Preda L,Noberasco C,Lazzari C,Toffalorio F,de Marinis F,Manzotti M,De Pas TM

更新日期：2014-05-08 00:00:00

abstract：Background:The relationship of inflammation and tumor is becoming more and more important in the study on the pathogenesis of colorectal cancer. The role of TLR9-mediated immune inflammation reaction in the process is not currently clear. The purpose of the study was to discuss the correlation of TLR9 signal activation...

journal_title：OncoTargets and therapy

authors： Gao C,Qiao T,Zhang B,Yuan S,Zhuang X,Luo Y

更新日期：2018-09-18 00:00:00

abstract：Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...

journal_title：OncoTargets and therapy

authors： Cortellini A,Cannita K,Parisi A,Lanfiuti Baldi P,Venditti O,D'Orazio C,Dal Mas A,Calvisi G,Giordano AV,Vicentini V,Vicentini R,Felicioni L,Marchetti A,Buttitta F,Russo A,Ficorella C

更新日期：2019-03-25 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare malignancy originating from calcitonin-producing parafollicular C cells of the thyroid. Neither radiotherapy nor chemotherapy has demonstrated durable objective responses in patients with advanced MTC. Vandetanib and cabozantinib are the 2 tyrosine kinase inhibitors recently...

journal_title：OncoTargets and therapy

authors： Chen K,Gao Y,Shi F,Cao G,Bao J

更新日期：2018-01-19 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：Background:Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance. Materials and methods:We explored the pub...

journal_title：OncoTargets and therapy

authors： Wang W,Han T,Tong W,Zhao J,Qiu X

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:To develop a targeting therapy for hormone-independent prostate cancer, we constructed and characterized conditionally replicating oncolytic adenovirus (Ad) equipped with mRFP (monomeric red fluorescence protein)/ttk (modified herpes simplex virus thymidine kinase). This construct was then further modified t...

journal_title：OncoTargets and therapy

authors： Kim JS,Lee SD,Lee SJ,Chung MK

更新日期：2013-11-12 00:00:00

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS:A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy...

journal_title：OncoTargets and therapy

authors： Joo JH,Kim YJ,Kim YS,Cho YP,Lee HY,Jeong CY,Kwak J,Cho BC

更新日期：2016-05-24 00:00:00

abstract：:Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...

journal_title：OncoTargets and therapy

authors： Han X,Guo X,Zhang W,Cong Q

更新日期：2019-06-20 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...

journal_title：OncoTargets and therapy

authors： Yue S,Shi H,Han J,Zhang T,Zhu W,Zhang D

更新日期：2016-10-11 00:00:00

abstract：Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...

journal_title：OncoTargets and therapy

authors： Wu W,Wang X,Shan C,Li Y,Li F

更新日期：2018-08-20 00:00:00

abstract：:Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...

journal_title：OncoTargets and therapy

authors： Yu Z,Quiroz E,Shen Y,Jaiyesimi IA

更新日期：2018-12-04 00:00:00

abstract：Background:Gastric tumor (GT) is associated with high morbidity and mortality, with surgery among the most effective treatment methods. Accurate interoperative determination of the tumor margin is crucial. Methods:In this study, using internal extractive electrospray ionization-MS, mass spectral data of GT and gastric...

journal_title：OncoTargets and therapy

authors： Zhang J,Gao Q,Luo X,Zhang W,Wang N,Wei Y

更新日期：2019-10-17 00:00:00

abstract：:Large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder of transformed natural killer or T-cells attributed to chronic exposure to the proinflammatory cytokine IL-15. Diagnosis of the majority of T-cell LGLL is established by documenting clonal large granular lymphocytes (LGLs) in peripheral ...

journal_title：OncoTargets and therapy

authors： Bagacean C,Tempescul A,Patiu M,Fetica B,Bumbea H,Zdrenghea M

更新日期：2016-12-19 00:00:00