Antitumor activity of sorafenib and imatinib in a patient with thymic carcinoma harboring c-KIT exon 13 missense mutation K642E.

abstract：:Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...

journal_title：OncoTargets and therapy

authors： Li F,Huang Q,Gong Z,Wang H,Chen J

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：:Despite improvements in multidisciplinary treatments, survival of pancreatic cancer (PC) patients remains dismal. Studies dealing with early onset pancreatic cancer (EOPC) patients are scarce. In this review, we discuss differences between EOPC and late-onset pancreatic cancer based on findings in original papers and ...

journal_title：OncoTargets and therapy

authors： Primavesi F,Stättner S,Schlick K,Kiesslich T,Mayr C,Klieser E,Urbas R,Neureiter D

更新日期：2019-05-06 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...

journal_title：OncoTargets and therapy

authors： Yuan ZY,Meng MB,Liu CL,Wang HH,Jiang C,Song YC,Zhuang HQ,Yang D,Wang JS,Wei W,Li FT,Zhao LJ,Wang P

更新日期：2014-06-12 00:00:00

abstract：:Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary man...

journal_title：OncoTargets and therapy

authors： Sun L,Qi Y,Sun X,Yu J,Meng X

更新日期：2016-05-09 00:00:00

abstract：Purpose:Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but the underlying mechanism is still unknown. Here, we explored the role of the NRF2/KEAP1 pathway in radioresistance of NPC cell lines. Materials and Methods:We selected NPC cell lines CNE-1 and CNE-2, treated them...

journal_title：OncoTargets and therapy

authors： Zhou J,Ding J,Ma X,Zhang M,Huo Z,Yao Y,Li D,Wang Z

更新日期：2020-09-11 00:00:00

abstract：Aim:We aimed to assess the role of 21-gene recurrence score (RS) in the decision-making for surgical treatment in early stage breast cancer and compared the outcomes between breast-conserving surgery (BCS) and mastectomy (MAST) among various 21-gene RS groups. Methods:We included patients with stage T1-2M0M0 and estro...

journal_title：OncoTargets and therapy

authors： Wu SG,Zhang WW,Wang J,Dong Y,Chen YX,He ZY

更新日期：2019-03-19 00:00:00

abstract：BACKGROUND:Computed tomography-guided transthoracic needle aspiration (TTNA) and biopsy (TTNB) is a well established, safe, and rapid method of reaching a definitive diagnosis for most thoracic lesions. The present study aimed to determine the roles of TTNA and TTNB in the diagnosis of pulmonary diseases and to compare...

journal_title：OncoTargets and therapy

authors： Tuna T,Ozkaya S,Dirican A,Findik S,Atici AG,Erkan L

更新日期：2013-11-05 00:00:00

abstract：Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...

journal_title：OncoTargets and therapy

authors： Su X,Zhang J,Fu C,Xiao M,Wang C

更新日期：2020-04-21 00:00:00

abstract：Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...

journal_title：OncoTargets and therapy

authors： Du X,Wang T,Wang Z,Wu X,Gu Y,Huang Q,Wang J,Xie J

更新日期：2020-03-09 00:00:00

abstract：:Purpose: Ornithine decarboxylase 1 (ODC1)-an oncogene involved in the biosynthesis of polyamines-is commonly upregulated and associated with poor prognosis in numerous cancers. However, the role and mechanism of ODC1 in hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to investigate the...

journal_title：OncoTargets and therapy

authors： Ye Z,Zeng Z,Shen Y,Yang Q,Chen D,Chen Z,Shen S

更新日期：2019-05-27 00:00:00

abstract：BACKGROUND:This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC). METHODS:PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure datab...

journal_title：OncoTargets and therapy

authors： Zhang Y,Zhu SL,Chen J,Li LQ

更新日期：2016-05-30 00:00:00

abstract：:[This retracts the article on p. 2215 in vol. 8, PMID: 26345468.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-02-04 00:00:00

abstract：Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...

journal_title：OncoTargets and therapy

authors： He Y,Wang Y,Zhao S,Zhao C,Zhou C,Hirsch FR

更新日期：2018-08-13 00:00:00

abstract：Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...

journal_title：OncoTargets and therapy

authors： Yan Z,Yin H,Lin G

更新日期：2020-10-28 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：:The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...

journal_title：OncoTargets and therapy

authors： Sun Y,Tao C,Huang X,He H,Shi H,Zhang Q,Wu H

更新日期：2016-05-12 00:00:00

abstract：Background and objective:HSF1 is reported to be overexpressed in various solid tumors and play a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of HSF1 in patients with solid tumors. Methods:An extensive electronic search of three databases was performed for r...

journal_title：OncoTargets and therapy

authors： Wan T,Shao J,Hu B,Liu G,Luo P,Zhou Y

更新日期：2018-01-17 00:00:00

abstract：BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...

journal_title：OncoTargets and therapy

authors： Zhao Y,Zheng X,Zhang L,Hu Q,Guo Y,Jiang H,Shi S,Zhang X

更新日期：2017-06-29 00:00:00

abstract：Purpose:Several studies have proved that single nucleotide polymorphisms (SNPs) of mismatch repair system genes are closely related to the development of colorectal cancer (CRC) by causing microsatellite instability, while effects of the SNPs of MMR system-related genes on the clinical outcomes of cytotoxic chemotherap...

journal_title：OncoTargets and therapy

authors： Wang D,Zhang X,Zhang Y,Wu Y,Guan X,Zhu W,Wang M,Qi C,Shen B

更新日期：2018-11-13 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the therapeutic efficacy and safety of trastuzumab emtansine (T-DM1) for the treatment of patients with human epidermal growth factor receptor 2-positive breast cancer. METHODS:We performed a systemic review and meta-analysis of the relevant published clinical studies. A c...

journal_title：OncoTargets and therapy

authors： Ma B,Ma Q,Wang H,Zhang G,Zhang H,Wang X

更新日期：2016-02-29 00:00:00

abstract：Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...

journal_title：OncoTargets and therapy

authors： Bayramov B,Gunes S,Buyukalpelli R,Aydın O,Henkel R

更新日期：2018-07-19 00:00:00

abstract：Background:Sex-determining region Y-box protein 5 (SOX5) has been demonstrated to be implicated in oncogenic function in various types of cancers. However, the role of SOX5 in gastric cancer (GC) remains poorly elucidated. Herein, we investigated the role and the underlying mechanism of SOX5 in GC progression. Methods...

journal_title：OncoTargets and therapy

authors： You J,Zhao Q,Fan X,Wang J

更新日期：2019-04-03 00:00:00

abstract：:We report a case of a 68-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed partial response after a single treatment with camrelizumab (PD1 monoclonal antibody). The patient's tumor was positive for programmed cell death ligand 1 (PD-L1) and progressed rapidly after a course of chemotherapy. Fortu...

journal_title：OncoTargets and therapy

authors： Chen Y,Zhang H,Shi J,Wang T

更新日期：2020-12-03 00:00:00

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVE:Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, the aim was to investigate the effects of emodin on EOC cells and to study fu...

journal_title：OncoTargets and therapy

authors： Lu J,Xu Y,Zhao Z,Ke X,Wei X,Kang J,Zong X,Mao H,Liu P

更新日期：2017-07-19 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast ...

journal_title：OncoTargets and therapy

authors： Ludmir EB,Gutschenritter T,Pinnix CC,Gunther JR,Nastoupil LJ,Khoury JD,Medeiros LJ,Dabaja BS,Milgrom SA

更新日期：2018-12-10 00:00:00

abstract：Introduction:Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA) and gene modules or representative biomarkers related to the pathological stage ...

journal_title：OncoTargets and therapy

authors： Zhou XG,Huang XL,Liang SY,Tang SM,Wu SK,Huang TT,Mo ZN,Wang QY

更新日期：2018-05-15 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of bortezomib-based vs non-bortezomib-based post-transplantation therapy in patients with multiple myeloma. METHODS:Data of relevant randomized controlled trials assessing the effect of bortezomib as post-transplantation consolidation or maintenance therapy was obtained th...

journal_title：OncoTargets and therapy

authors： Liu X,He CK,Meng X,He L,Li K,Liang Q,Shao L,Liu S

更新日期：2015-06-15 00:00:00