Emodin suppresses proliferation, migration and invasion in ovarian cancer cells by down regulating ILK in vitro and in vivo.

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...

journal_title：OncoTargets and therapy

authors： Du X,Wang T,Wang Z,Wu X,Gu Y,Huang Q,Wang J,Xie J

更新日期：2020-03-09 00:00:00

abstract：:Extranodal NK/T-cell lymphoma is closely associated with Epstein-Barr virus (EBV) infection. However, the prognostic value of EBV-DNA in extranodal NK/T-cell lymphoma remains unclear. Thus, we conducted a meta-analysis to estimate its prognostic significance. PubMed, EMBASE, and Web of Science were used to search for ...

journal_title：OncoTargets and therapy

authors： Fei Q,Tian XK,Wu J,Zhu HM,Wang Y,Peng FY,Zhang WJ,Yin L,He X

更新日期：2018-02-26 00:00:00

abstract：:Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. Although AGR3 was found in breast, ovary, prostate, and liver cancer, it remains of yet poorly defined function in tumorigenesis. This study aimed to determine AGR3 expressio...

journal_title：OncoTargets and therapy

authors： Obacz J,Brychtova V,Podhorec J,Fabian P,Dobes P,Vojtesek B,Hrstka R

更新日期：2015-06-24 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：Introduction:Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small sp...

journal_title：OncoTargets and therapy

authors： Tan Y,Lu X,Cheng Z,Pan G,Liu S,Apiziaji P,Wang H,Zhang J,Abulimiti Y

更新日期：2020-08-13 00:00:00

abstract：Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...

journal_title：OncoTargets and therapy

authors： Cheng LC,Chao YJ,Wang CY,Phan NN,Chen YL,Wang TW,Hsu HP,Lin YJ,Shan YS,Lai MD

更新日期：2020-08-03 00:00:00

abstract：:Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....

journal_title：OncoTargets and therapy

authors： Yi F,Du J,Ni W,Liu W

更新日期：2017-02-20 00:00:00

abstract：:We report a case of a 68-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed partial response after a single treatment with camrelizumab (PD1 monoclonal antibody). The patient's tumor was positive for programmed cell death ligand 1 (PD-L1) and progressed rapidly after a course of chemotherapy. Fortu...

journal_title：OncoTargets and therapy

authors： Chen Y,Zhang H,Shi J,Wang T

更新日期：2020-12-03 00:00:00

abstract：Background:Insulin-like growth factor binding protein-2 (IGFBP2) levels are significantly increased in the plasma of hepatocellular carcinoma (HCC) patients. However, the correlation between IGFBP2 levels and clinical parameters and the exact role of IGFBP2 in HCC are unclear. In this study, we identified the role and ...

journal_title：OncoTargets and therapy

authors： Ma Y,Cui D,Zhang Y,Han CC,Wei W

更新日期：2020-06-08 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Background:Cellular senescence-inhibited gene (CSIG) strongly prolongs the progression of replicative senescence. However, roles and mechanisms of CSIG in tumor progression have not been studied widely. Methods:Roles of CSIG in migration and proliferation of SMMC7721 and Huh7 cells were analyzed by transwell or cell v...

journal_title：OncoTargets and therapy

authors： Cheng Q,Tong TJ,Li Z,Hu SH,Chen DB,Wang SQ,Zhu JY

更新日期：2019-03-15 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：:POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. ...

journal_title：OncoTargets and therapy

authors： Găman M,Vlădăreanu AM,Dobrea C,Onisâi M,Marinescu C,Cîşleanu D,Ciufu C,Vasile D,Bumbea H,Voican I

更新日期：2018-09-27 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：Background:Nasopharyngeal carcinoma (NPC) is a common malignant cancer that is distributed particularly in Southeastern Asia. Previous studies have manifested that long noncoding RNA urothelial carcinoma associated 1 (UCA1) was involved in NPC tumorigenesis and metastasis. However, the biological mechanism of UCA1 for ...

journal_title：OncoTargets and therapy

authors： Liu C,Zhang H,Liu H

更新日期：2019-10-11 00:00:00

abstract：Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...

journal_title：OncoTargets and therapy

authors： Rao C,Nie L,Miao X,Xu Y,Li B,Zhang T

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:We aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT) combined with chemotherapy. PATIENTS AND METHODS:From April 2006 to December 2011, ...

journal_title：OncoTargets and therapy

authors： Maklad AM,Bayoumi Y,Senosy Hassan MA,Elawadi AA,AlHussain H,Elyamany A,Aldhahri SF,Al-Qahtani KH,AlQahtani M,Tunio MA

更新日期：2016-10-25 00:00:00

abstract：Introduction:Melanoma has been reported as the most common malignancy in skin cancer. The small nucleolar RNA host gene 5 (SNHG5), an lncRNA, has been proven as a vital regulator in several types of carcinoma. This study was designed to investigate the detailed roles and possible mechanisms of SNHG5 in melanoma progres...

journal_title：OncoTargets and therapy

authors： Gao J,Zeng K,Liu Y,Gao L,Liu L

更新日期：2018-12-24 00:00:00

abstract：Background:Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used as effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatech...

journal_title：OncoTargets and therapy

authors： Meng J,Chang C,Chen Y,Bi F,Ji C,Liu W

更新日期：2019-07-26 00:00:00

abstract：Background:Osteosarcoma (OSA), the most common primary bone malignancy, is characterized by a wide spectrum of complicated pathologies and frequent distal metastasis and causes death in adolescents and young adults worldwide. Antitumor drug treatment strategies include various cytotoxic chemotherapy drugs, while molecu...

journal_title：OncoTargets and therapy

authors： Wang L,En H,Yang L,Zhang Y,Sun B,Gao J

更新日期：2019-08-21 00:00:00

abstract：Purpose:This study aimed to investigate the regulatory roles of estrogen receptor beta (ERβ) on gastric cancer (GC) cells, and reveal the potential mechanisms relating to nuclear factor-kappa B (NF-κB) signaling. Methods:GC cell lines SGC7901 and MKN45 were transfected with pEGFP-C1-ERβ to overexpress ERβ, and treated...

journal_title：OncoTargets and therapy

authors： Zhang Y,Wu Y,Zhou X,Yi B,Wang L

更新日期：2019-11-05 00:00:00

abstract：Background:PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-relat...

journal_title：OncoTargets and therapy

authors： He W,Zhang X,Li W,Kong C,Wang Y,Zhu L,Xu R,Deng G,Zhang P

更新日期：2018-10-24 00:00:00

abstract：:Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncog...

journal_title：OncoTargets and therapy

authors： Yang F,Zhang C,Xu C,Fu F,Han D,Li H

更新日期：2019-06-05 00:00:00

abstract：Purpose:Traditional Chinese medicine (TCM) has gained increasing attention for the treatment of multiple chronic diseases, such as cancer. Here we aim to identify the antitumor activity of Sichong formula, a novel TCM, in human gastric cancer cells and investigate the underlying mechanisms. Methods:The AGS and MKN45 g...

journal_title：OncoTargets and therapy

authors： Wang M,Tian Z,Zhu Y,Ding J,Li C,Zhou Y,Zhang Y

更新日期：2019-07-16 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：OBJECTIVE:Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histo...

journal_title：OncoTargets and therapy

authors： Foroulis CN,Kleontas AD,Tagarakis G,Nana C,Alexiou I,Grosomanidis V,Tossios P,Papadaki E,Kioumis I,Baka S,Zarogoulidis P,Anastasiadis K

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Recent studies show that epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression and poor prognosis of carcinoma through multiple mechanisms. Both inflammation and changing of epithelium have a close relationship with tumorigenesis of gastric cancer. Howe...

journal_title：OncoTargets and therapy

authors： Yan Y,Zhang J,Li JH,Liu X,Wang JZ,Qu HY,Wang JS,Duan XY

更新日期：2016-06-30 00:00:00

abstract：:Whether the addition of induction chemotherapy (IC) or adjuvant chemotherapy (AC) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locally advanced nasopharyngeal cancer is unknown. A Bayesian network meta-analysis was performed to investigate the efficacy of CCRT, IC + CCRT, and CCRT + AC on local...

journal_title：OncoTargets and therapy

authors： Yu H,Gu D,He X,Gao X,Bian X

更新日期：2016-01-05 00:00:00

abstract：Objective:Long non-coding RNA (lncRNA) ANRIL is emerging as a crucial role in ovarian cancer progression and prognosis. However, the precise molecular mechanism of ANRIL on ovarian cancer is not known. Thus, we aim to study the underlying mechanism of ANRIL on the action. Methods:The MTT assay assessed cell viability....

journal_title：OncoTargets and therapy

authors： Wang K,Hu YB,Zhao Y,Ye C

更新日期：2021-01-19 00:00:00