Abstract:
:Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncogenicity of GBM cells in vitro and in vivo. Material and methods: Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was carried out to determine miR-559 expression in GBM tissues and cell lines. A series of functional assays was performed to evaluate the effects of miR-559 overexpression on GBM cell proliferation, apoptosis, migration, and invasion in vitro and on GBM tumor growth in vivo. The regulatory mechanisms of miR-559 action in GBM cells were then explored. Results: The expression of miR‑559 was lower in GBM tissues and cell lines and significantly correlated with the Karnofsky performance score and tumor size among patients with GBM. Exogenous miR‑559 expression inhibited GBM cell proliferation, migration, and invasion and promoted apoptosis. MiR-559 overexpression decreased tumor growth in vivo. Mechanistic experiments confirmed metadherin (MTDH) as a direct target gene of miR-559 in GBM. Silencing of MTDH induced effects similar to those of miR-559 upregulation in GBM cells, whereas MTDH expression restoration attenuated the antitumor effects of miR‑559 in GBM cells. Protein kinase B (AKT) in the phosphatase and tensin homolog (PTEN)-AKT signaling pathway was found to be deactivated in GBM cells after upregulation of miR-559 both in vitro and in vivo. Conclusion: MiR-559 acts as a tumor suppressor in GBM cells in vitro and in vivo, at least in part through the downregulation of MTDH and inhibition of AKT in the PTEN-AKT pathway. Therefore, targeting the miR-559-MTDH axis may be a promising therapeutic strategy for patients with GBM.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Yang F,Zhang C,Xu C,Fu F,Han D,Li Hdoi
10.2147/OTT.S202309subject
Has Abstractpub_date
2019-06-05 00:00:00pages
4415-4426issn
1178-6930pii
202309journal_volume
12pub_type
杂志文章abstract::Programmed cell death-1 (PD-1) immune checkpoint inhibitors have exhibited promising efficacy in various types of tumors. Here, we report an unresectable locally advanced gastric cancer (GC) with programmed cell death ligand-1 (PD-L1) positive and microsatellite instability (MSI), which exhibiting an unexpected effica...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S243298
更新日期:2020-02-26 00:00:00
abstract:Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,收录出版
doi:10.2147/OTT.S210697
更新日期:2019-10-30 00:00:00
abstract::Purpose: Ornithine decarboxylase 1 (ODC1)-an oncogene involved in the biosynthesis of polyamines-is commonly upregulated and associated with poor prognosis in numerous cancers. However, the role and mechanism of ODC1 in hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to investigate the...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198341
更新日期:2019-05-27 00:00:00
abstract:Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S252043
更新日期:2020-07-07 00:00:00
abstract:Background:Long non-coding RNAs (lncRNAs) can affect tumorigenesis. Data from The Cancer Genome Atlas (TCAG) suggest that LINC02783 is highly expressed in renal cell carcinoma (RCC) and is expected to be a potential biological target. We conducted this study to verify this. Patients and Methods:We conducted this study...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S262046
更新日期:2020-10-09 00:00:00
abstract:Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S246714
更新日期:2020-08-03 00:00:00
abstract::The mortality of hepatobiliary cancer still stays high around the world, with disappointing treatment status at advanced stage. Genomic analysis has identified the global spectrum of alterations in liver cancer, but the most common mutations are not actionable, meanwhile lacking potent molecular-targeted drugs for spe...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S223568
更新日期:2019-11-19 00:00:00
abstract:Background:This study was designed to research the potential function of lncRNA ANRIL in osteosarcoma (OS). Materials and methods:Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out. Results:ANRIL...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S170293
更新日期:2018-08-14 00:00:00
abstract:Background:A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160428
更新日期:2018-06-06 00:00:00
abstract::Targeted therapies against EGFR, vascular endothelial growth factor, and vascular endothelial growth factor receptor have expanded treatment options for patients with metastatic colorectal cancer (mCRC). Unfortunately, biomarkers to identify patients that are most likely to derive benefit from targeted therapies in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S68558
更新日期:2015-12-30 00:00:00
abstract::Whether the addition of induction chemotherapy (IC) or adjuvant chemotherapy (AC) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locally advanced nasopharyngeal cancer is unknown. A Bayesian network meta-analysis was performed to investigate the efficacy of CCRT, IC + CCRT, and CCRT + AC on local...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S96983
更新日期:2016-01-05 00:00:00
abstract:Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S286169
更新日期:2020-12-09 00:00:00
abstract::Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S105587
更新日期:2016-05-20 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a key mediator that plays an important role in angiogenesis, tumor growth, and tumor metastasis. The associations between five polymorphisms of VEGF (rs3025039, rs699947, rs10434, rs1570360, and rs2010963) and renal cell carcinoma (RCC) risk have been extensively ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S125965
更新日期:2017-03-21 00:00:00
abstract:Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266095
更新日期:2020-10-15 00:00:00
abstract:PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S52365
更新日期:2013-11-29 00:00:00
abstract:BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S30609
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S142587
更新日期:2017-07-17 00:00:00
abstract::Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL), which belong to the family of Argonaute genes/proteins, bind to piRNAs and function mainly in germ line cells, but...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S91295
更新日期:2016-01-08 00:00:00
abstract:Introduction:Cyclophosphamide, which is widely used to treat malignant disease, causes ovarian follicular atresia, which leads to premature ovarian insufficiency. The present study evaluated the protective effect of testosterone in preventing the decline in the ovarian reserve during cyclophosphamide treatment. Method...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S242703
更新日期:2020-04-08 00:00:00
abstract::Angiogenesis plays an essential role in the development of most solid tumors by delivering nutrients and oxygen to the tumor. Therefore, anti-angiogenic therapy, particularly anti-VEGF and anti-VEGF receptor (VEGFR) therapy, has been a popular strategy to treat cancer. However, anti-angiogenic therapy does not signifi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S276150
更新日期:2020-11-24 00:00:00
abstract:Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S207613
更新日期:2020-02-17 00:00:00
abstract:Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S174846
更新日期:2018-10-05 00:00:00
abstract:BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S44177
更新日期:2013-06-20 00:00:00
abstract:Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230875
更新日期:2020-07-01 00:00:00
abstract::The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S81087
更新日期:2016-03-01 00:00:00
abstract:Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S229076
更新日期:2020-06-10 00:00:00
abstract:INTRODUCTION:The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung cancer (NSCLC) with EGFR+ mutations. However, most patients develop resistance, with the result that median progression-free survival (PFS) iŝ1...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S134382
更新日期:2017-05-05 00:00:00
abstract:OBJECTIVE:To evaluate efficacy and safety of nimotuzumab combined with chemotherapy and radiotherapy in women with locally advanced cervical cancer. MATERIALS AND METHODS:Women with locally advanced cervical cancer (stage IIB, III, or IVA) who experienced relapse after first-line chemoradiotherapy and one or more line...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S133756
更新日期:2017-08-17 00:00:00
abstract:PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S124311
更新日期:2016-11-24 00:00:00