ITPKA1 Promotes Growth, Migration and Invasion of Renal Cell Carcinoma via Activation of mTOR Signaling Pathway.

abstract：BACKGROUND:Two types of epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 (ex19del and L858R) are prevalent in lung cancer patients and sensitive to targeted EGFR inhibition. A resistance mutation in exon 20 (T790M) has been found to accompany drug treatment when patients relapse. These three mut...

journal_title：OncoTargets and therapy

authors： Xu Q,Zhu Y,Bai Y,Wei X,Zheng X,Mao M,Zheng G

更新日期：2015-06-22 00:00:00

abstract：:Acute pancreatitis is a rare complication in postoperative colorectal cancer patients after FOLFOX6 (oxaliplatin + calcium folinate +5-FU [5-fluorouracil]) chemotherapy. In this paper, a total of 62 patients with gastrointestinal cancer were observed after the burst of acute pancreatitis. Surgery of the 62 cases of co...

journal_title：OncoTargets and therapy

authors： Ji Y,Han Z,Shao L,Li Y,Zhao L,Zhao Y

更新日期：2015-09-11 00:00:00

abstract：Background:MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure. Methods:The effect of miR-647 and TRAF2 on A549 and H1299 cells was explored through Methyl thiazolyl tetrazolium (MTT) assay, colony formation and cell cy...

journal_title：OncoTargets and therapy

authors： Zhang YS,Chen T,Cai YJ,Dong J,Bai F,Gao X,Tian L,Duan N,Liu D

更新日期：2018-10-10 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：Background and aim:Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with n...

journal_title：OncoTargets and therapy

authors： Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR

更新日期：2017-11-10 00:00:00

abstract：Background:The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma. Patients and methods:A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (ge...

journal_title：OncoTargets and therapy

authors： Nie Y,Liu H,Tan X,Wang H,Li F,Li C,Han P,Lyv X,Xu X,Guo M

更新日期：2019-01-10 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...

journal_title：OncoTargets and therapy

authors： Zhao X,Hu GF,Shi YF,Xu W

更新日期：2019-12-24 00:00:00

abstract：:The identification of molecular genetic biomarkers considerably increased our current understanding of glioma genesis, prognostic evaluation, and treatment planning. In glioblastoma, the most malignant intrinsic brain tumor entity in adults, the promoter methylation status of the gene encoding for the repair enzyme O6...

journal_title：OncoTargets and therapy

authors： Thon N,Kreth S,Kreth FW

更新日期：2013-09-27 00:00:00

abstract：Purpose:Aberrant activation of the Janus-associated kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is associated with increased malignant cell proliferation and survival. This Phase Ib study evaluated ruxolitinib, a potent JAK1/2 inhibitor, in combination with gemcitabine with or without n...

journal_title：OncoTargets and therapy

authors： Bauer TM,Patel MR,Forero-Torres A,George TJ Jr,Assad A,Du Y,Hurwitz H

更新日期：2018-04-30 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：:Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors,...

journal_title：OncoTargets and therapy

authors： Mahecha AM,Wang H

更新日期：2017-09-19 00:00:00

abstract：Background:LncRNA LINC00461 has been reported to play crucial regulatory roles in a variety of biological processes, including cell migration, cell invasion and cancer progression. However, its biological role in colorectal cancer (CRC) is completely unknown. The aim of our study was to explore the function of LINC0046...

journal_title：OncoTargets and therapy

authors： Yu H,Ma J,Chen J,Yang Y,Liang J,Liang Y

更新日期：2019-12-17 00:00:00

abstract：Background:Bladder cancer (BC) is one of the most prevalent malignancies of the genitourinary system, yet the underlying mechanism of BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers deve...

journal_title：OncoTargets and therapy

authors： Han N,Yuan F,Xian P,Liu N,Liu J,Zhang H,Zhang H,Yao K,Yuan G

更新日期：2019-09-16 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:The aim of this study was to examine the patterns of expression of epithelial-mesenchymal transition (EMT)-related proteins in intrahepatic cholangiocarcinoma. The clinicopathological and prognostic value of these markers was also evaluated. METHODS:We detected the expression status of three EMT-related pro...

journal_title：OncoTargets and therapy

authors： Yao X,Wang X,Wang Z,Dai L,Zhang G,Yan Q,Zhou W

更新日期：2012-01-01 00:00:00

abstract：Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...

journal_title：OncoTargets and therapy

authors： Wang Z,Zhang C,Chang J,Tian X,Zhu C,Xu W

更新日期：2020-07-21 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate an intravoxel incoherent motion (IVIM) model-based analysis of diffusion-weighted imaging (DWI) for assessing the response of hepatocellular carcinoma (HCC) to locoregional therapy. PATIENTS AND METHODS:Respiratory-gated DWI (b=0, 50, and 800 s/mm2) was retrospectively ana...

journal_title：OncoTargets and therapy

authors： Mürtz P,Penner AH,Pfeiffer AK,Sprinkart AM,Pieper CC,König R,Block W,Schild HH,Willinek WA,Kukuk GM

更新日期：2016-10-19 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality in both sexes, accounting for over one quarter of cancer deaths. Non-small-cell lung cancer (NSCLC) comprises 85%-90% of lung cancer diagnoses and despite advances in multimodality therapies, 5-year survival rates remain dismal with a median survival for pat...

journal_title：OncoTargets and therapy

authors： Kanaan Z,Kloecker GH,Paintal A,Perez CA

更新日期：2015-04-20 00:00:00

abstract：:Background/Aims: MiR-145 and Smad2 have been widely reported in the development and progression of human malignancies. In the present study, we investigated the correlation between miR-145 and Smad2 in human glioblastoma multiforme (GBM). Methods: The epithelial-mesenchymal transition (EMT) biomarkers and Smad2 were a...

journal_title：OncoTargets and therapy

authors： Chen W,Huang B,Wang E,Wang X

更新日期：2019-04-23 00:00:00

abstract：Background:Despite the breadth of understanding the noncoding RNAs' function in molecular biology, their functional roles in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated the effect of hepatitis C virus (HCV) core upon the expression of noncoding RNAs. Methods:The lncRNAs, mRNAs, ...

journal_title：OncoTargets and therapy

authors： Wang X,Peng J,Wang J,Li M,Wu D,Wu S,Liao J,Dou J

更新日期：2018-03-02 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) have been verified to have a vital role in the progression of glioblastoma multiforme (GBM). Our research was about to identify the potential lncRNAs which was closely associated with the pathogenesis and prognosis of glioblastoma multiforme. Methods:All RNA sequence profiling...

journal_title：OncoTargets and therapy

authors： Li Y,Guo D

更新日期：2020-02-04 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：Purpose:Hepatocellular carcinoma (HCC) has a high incidence in China and exploring effective ways for early diagnosis is an important method to improve the prognosis of patients with HCC. Additional studies reported that. Some kinds of microRNA (miRNA) in plasma will change accordingly during HCC progress, and this cha...

journal_title：OncoTargets and therapy

authors： Wang S,Yang Y,Sun L,Qiao G,Song Y,Liu B

更新日期：2020-03-09 00:00:00

abstract：Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...

journal_title：OncoTargets and therapy

authors： Wang D,Xiang Y,Wu M,Shen K,Yang J,Huang H,Ren T

更新日期：2018-03-07 00:00:00

abstract：Background:Circular RNAs (circRNAs) are a special class of noncoding RNAs that are involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of circRNAs in cancer, especially breast cancer (BC), are poorly understood. Materials and Methods:The expression levels of circRNA 0001073 (circ-1073)...

journal_title：OncoTargets and therapy

authors： Yi Z,Li Y,Wu Y,Zeng B,Li H,Ren G,Wang X

更新日期：2020-06-29 00:00:00

abstract：Introduction:Melanoma has been reported as the most common malignancy in skin cancer. The small nucleolar RNA host gene 5 (SNHG5), an lncRNA, has been proven as a vital regulator in several types of carcinoma. This study was designed to investigate the detailed roles and possible mechanisms of SNHG5 in melanoma progres...

journal_title：OncoTargets and therapy

authors： Gao J,Zeng K,Liu Y,Gao L,Liu L

更新日期：2018-12-24 00:00:00

abstract：Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...

journal_title：OncoTargets and therapy

authors： Pan G,Ma Y,Suo J,Li W,Zhang Y,Qin S,Jiao Y,Zhang S,Li S,Kong Y,Du Y,Gao S,Wang D

更新日期：2020-07-27 00:00:00