Abstract:
PURPOSE:The aim of this study was to evaluate an intravoxel incoherent motion (IVIM) model-based analysis of diffusion-weighted imaging (DWI) for assessing the response of hepatocellular carcinoma (HCC) to locoregional therapy. PATIENTS AND METHODS:Respiratory-gated DWI (b=0, 50, and 800 s/mm2) was retrospectively analyzed in 25 patients who underwent magnetic resonance imaging at 1.5 T before and 6 weeks following the first cycle of transarterial chemoembolization therapy, transarterial ethanol-lipiodol embolization therapy, and transarterial radioembolization therapy. In addition to the determination of apparent diffusion coefficient, ADC(0,800), an estimation of the diffusion coefficient, D', and the perfusion fraction, f', was performed by using a simplified IVIM approach. Parameters were analyzed voxel-wise. Tumor response was assessed in a central slice by using a region of interest (ROI) covering the whole tumor. HCCs were categorized into two groups, responders and nonresponders, according to tumor size changes on first and second follow ups (if available) and changes of contrast-enhanced region on the first follow up. RESULTS:In total, 31 HCCs were analyzed: 17 lesions were assigned to responders and 14 were to nonresponders. In responders, ADC(0,800) and D' were increased after therapy by ~30% (P=0.00004) and ~42% (P=0.00001), respectively, whereas f' was decreased by ~37% (P=0.00094). No significant changes were found in nonresponders. Responders and nonresponders were better differentiated by changes in D' than by changes in ADC(0,800) (area under the curve =0.878 vs 0.819 or 0.714, respectively). CONCLUSION:In patients with HCCs undergoing embolization therapy, diffusion changes were better reflected by D' than by conventional ADC(0,800), which is influenced by counteracting perfusion changes as assessed by f'.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Mürtz P,Penner AH,Pfeiffer AK,Sprinkart AM,Pieper CC,König R,Block W,Schild HH,Willinek WA,Kukuk GMdoi
10.2147/OTT.S113909subject
Has Abstractpub_date
2016-10-19 00:00:00pages
6425-6433issn
1178-6930pii
ott-9-6425journal_volume
9pub_type
杂志文章abstract::miRNAs (miRs) are short RNA molecules that are involved in the posttranscriptional regulation of mRNA. The roles of miRs in tumor pathogenesis have only recently become a focus of research. It is becoming increasingly clear that miRs are important regulators of apoptosis, proliferation, invasion, and metastasis in can...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S52730
更新日期:2013-11-18 00:00:00
abstract::Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S79145
更新日期:2015-10-15 00:00:00
abstract:Objective:The biological functions and molecular mechanisms of miR-935 have been widely investigated in various types of cancer. The aim of the present study was to explore the function of miR-935 in glioma. Methods:Bioinformatic analysis and quantitative real-time fluorescent PCR (qRT-PCR) were used to determine the ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S244409
更新日期:2020-10-23 00:00:00
abstract:Background:To investigate the effect of topical application of CpG oligodeoxynucleotide (CpG-ODN) combined with anti-4-1BB antibodies on mouse HCC multiple tumor-bearing models and the degree of improvement of anti-tumor immune response in mice. Materials and Methods:We inoculated each BALB/c male mouse subcutaneously...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S260353
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/ott.s3590
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted eff...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S93790
更新日期:2016-03-09 00:00:00
abstract::Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S121619
更新日期:2016-12-20 00:00:00
abstract::Tamoxifen was the first targeted anticancer agent for breast cancer patients and its effects on reduction of breast cancer events and improvement in overall survival are undisputed. Hence, it has long been considered an essential part of patient care. Recent results of several large adjuvant hormonal trials evaluating...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S10155
更新日期:2010-12-17 00:00:00
abstract:BACKGROUND:The PI3K family participates in multiple signaling pathways to regulate cellular functions. PI3K/Akt signaling pathway plays an important role in tumorigenesis and development. O-GlcNAcylation, a posttranslational modification, is thought to modulate a wide range of biological processes, such as transcriptio...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S82845
更新日期:2015-11-09 00:00:00
abstract:Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S243552
更新日期:2020-07-21 00:00:00
abstract:Background:Cervical cancer (CC) is a highly prevalent cancer and one of the main causes of death among women worldwide. The miR-181 family has turned out to be associated with tumorigenesis in a variety of tumors by regulating the expression of tumor-related genes. However, the mechanisms and biological function of miR...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S245254
更新日期:2020-05-21 00:00:00
abstract:Introduction:Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to play a significant role in obesity, diabetes, and osteopenia, and has been shown to be upregulated in head and neck squamous cell ca...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160831
更新日期:2018-07-12 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate clinical outcomes of conventional fractionated helical tomotherapy in patients with small to medium hepatocellular carcinomas (HCCs) without portal vein tumor thrombosis. METHODS:Patients with up to four HCC lesions not treatable by surgery or percutaneous ablative ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S69618
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS:Human breast cancer cell line MCF-7 and normal ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S93305
更新日期:2015-12-21 00:00:00
abstract::[This retracts the article DOI: 10.2147/OTT.S232594.]. ...
journal_title:OncoTargets and therapy
pub_type: 撤回出版物
doi:10.2147/OTT.S283590
更新日期:2020-10-07 00:00:00
abstract:Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157613
更新日期:2018-05-22 00:00:00
abstract:BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92769
更新日期:2015-11-04 00:00:00
abstract:BACKGROUND:C-X-C chemokine receptor type 4 (CXCR4) is involved in tumor progression including angiogenesis, metastasis, and survival. However, whether serum CXCR4 levels in metastatic or recurrent colorectal cancer have a prognostic role, have not been evaluated. METHODS:We analyzed serum samples from 55 patients with...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S104511
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S30609
更新日期:2012-01-01 00:00:00
abstract:Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219429
更新日期:2019-09-23 00:00:00
abstract::The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S142587
更新日期:2017-07-17 00:00:00
abstract:Background:Since colorectal cancer (CRC) is one of the most common malignant tumors worldwide, we aimed to identify the role of sex determining region Y (SRY)-box 18 (SOX18) in CRC. Methods:RT-PCR and immunohistochemistry were employed to detect the expression of SOX18 in CRC samples. We then identified the effect of ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S178916
更新日期:2018-11-29 00:00:00
abstract::Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S64685
更新日期:2014-07-23 00:00:00
abstract::The association between polymorphic CAG repeats in the androgen receptor gene in women and breast cancer susceptibility has been studied extensively. However, the conclusions regarding this relationship remain conflicting. The purpose of this meta-analysis was to identify whether androgen receptor CAG repeat lengths w...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S85130
更新日期:2015-08-13 00:00:00
abstract::Androgen deprivation therapy (ADT) is well established as a backbone therapy for metastatic prostate cancer (mPCa), and both European and American guidelines emphasize the importance of maintaining ADT after progression to metastatic castration-resistant prostate cancer (CRPC). However, the use of ADT varies widely in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S117176
更新日期:2016-11-29 00:00:00
abstract::POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. ...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S146221
更新日期:2018-09-27 00:00:00
abstract:Background:MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure. Methods:The effect of miR-647 and TRAF2 on A549 and H1299 cells was explored through Methyl thiazolyl tetrazolium (MTT) assay, colony formation and cell cy...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S159337
更新日期:2018-10-10 00:00:00
abstract:Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S245663
更新日期:2020-07-27 00:00:00
abstract:Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S164178
更新日期:2018-08-13 00:00:00
abstract:Purpose:Gastric carcinoma is the second most frequently diagnosed cancer and leading cause of cancer death in China. As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects in gastric cancer (GC). However, whether CL-6 s...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S196914
更新日期:2019-03-27 00:00:00