Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment.

abstract：:The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathological...

journal_title：OncoTargets and therapy

authors： Zhuang PH,Xu L,Gao L,Lu W,Ruan LT,Yang J

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:To evaluate the benefit of second-line chemotherapy with platinum-based treatment in patients with recurrent small cell lung cancer (SCLC). PATIENTS AND METHODS:A total of 535 patients continued with follow-up or best supportive care if needed, and 229 patients who progressed after the completion of first-l...

journal_title：OncoTargets and therapy

authors： Zarogoulidis K,Boutsikou E,Zarogoulidis P,Darwiche K,Freitag L,Porpodis K,Latsios D,Kontakiotis T,Huang H,Li Q,Hohenforst-Schmidt W,Kipourou M,Turner JF,Spyratos D

更新日期：2013-10-22 00:00:00

abstract：Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...

journal_title：OncoTargets and therapy

authors： Wang X,Lu Q,Fei X,Zhao Y,Shi B,Li C,Chen H

更新日期：2020-02-12 00:00:00

abstract：Introduction:Systemic inflammation is associated with prognosis in solid tumors. The neutrophil-to-lymphocyte ratio (NLR) is a marker for the general immune response to various stress stimuli. Studies have shown correlation of NLR to outcomes in immune checkpoint blockade, peripheral neutrophil count to intratumor neut...

journal_title：OncoTargets and therapy

authors： Sacdalan DB,Lucero JA,Sacdalan DL

更新日期：2018-02-23 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase phosphorylat...

journal_title：OncoTargets and therapy

authors： Ammendola M,Sacco R,Sammarco G,Piardi T,Zuccalà V,Patruno R,Zullo A,Zizzo N,Nardo B,Marech I,Crovace A,Gadaleta CD,Pessaux P,Ranieri G

更新日期：2016-07-21 00:00:00

abstract：Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...

journal_title：OncoTargets and therapy

authors： Wang D,Xiang Y,Wu M,Shen K,Yang J,Huang H,Ren T

更新日期：2018-03-07 00:00:00

abstract：Background:The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progressio...

journal_title：OncoTargets and therapy

authors： Jin Y,Xie H,Duan L,Zhao D,Ding J,Jiang G

更新日期：2019-10-31 00:00:00

abstract：Purpose:As a novel type of non-coding RNAs, circRNAs were found to play important roles in cancer progression. In this study, we aim to investigate genome-wide circRNAs expression and potential functions in glioma to find new therapeutic targets for glioma treatment. Patients and Methods:A total of 92 pairs of glioma ...

journal_title：OncoTargets and therapy

authors： Lyu X,Zhou L,Fan F,Dong Z

更新日期：2020-04-01 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00

abstract：Aim:We aimed to assess the role of 21-gene recurrence score (RS) in the decision-making for surgical treatment in early stage breast cancer and compared the outcomes between breast-conserving surgery (BCS) and mastectomy (MAST) among various 21-gene RS groups. Methods:We included patients with stage T1-2M0M0 and estro...

journal_title：OncoTargets and therapy

authors： Wu SG,Zhang WW,Wang J,Dong Y,Chen YX,He ZY

更新日期：2019-03-19 00:00:00

abstract：Introduction:The purpose of our research was to evaluate MT1JP in breast cancer. Material and Methods:For clinical purpose, tissues were collected, and a correlation analysis ofMT1JP and miRNA-214 gene expressions was conducted. Using an in vitro study, MDA-MB-231 and MCF-7 cell lines were used as research objects in ...

journal_title：OncoTargets and therapy

authors： Ouyang Q,Cui Y,Yang S,Wei W,Zhang M,Zeng J,Qu F

更新日期：2020-06-04 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：:The development of deep-sequencing methods is now unveiling a new landscape of previously undetected gene fusion across different tumor types. Chromosomal translocation involving the NTRK gene family occur across a wide range of cancers in both children and adults. Preclinical studies have demonstrated that chimeric p...

journal_title：OncoTargets and therapy

authors： Ricciuti B,Genova C,Crinò L,Libra M,Leonardi GC

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...

journal_title：OncoTargets and therapy

authors： Halpern N,Goldberg Y,Kadouri L,Duvdevani M,Hamburger T,Peretz T,Hubert A

更新日期：2017-03-29 00:00:00

abstract：Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...

journal_title：OncoTargets and therapy

authors： Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PG

更新日期：2020-11-16 00:00:00

abstract：:Tamoxifen was the first targeted anticancer agent for breast cancer patients and its effects on reduction of breast cancer events and improvement in overall survival are undisputed. Hence, it has long been considered an essential part of patient care. Recent results of several large adjuvant hormonal trials evaluating...

journal_title：OncoTargets and therapy

authors： Criscitiello C,Fumagalli D,Saini KS,Loi S

更新日期：2010-12-17 00:00:00

abstract：:Human testis development-related gene 1 (TDRG1) is a recently identified gene that is expressed exclusively in the testes and promotes the development of testicular germ cell tumors. In this study, the role of TDRG1 in the development of testicular seminoma, which is the most common testicular germ cell tumor, was fur...

journal_title：OncoTargets and therapy

authors： Wang Y,Gan Y,Tan Z,Zhou J,Kitazawa R,Jiang X,Tang Y,Yang J

更新日期：2016-01-20 00:00:00

abstract：Background:Erlotinib is a commonly used molecular-targeted drug for the treatment of tongue cancer. However, the development of acquired resistance to erlotinib hampers its therapeutic use. Materials and methods:To analyze the erlotinib resistance, long-term and short term survival assay were used to compare the resis...

journal_title：OncoTargets and therapy

authors： Huang K,Liu D

更新日期：2018-09-05 00:00:00

abstract：:Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....

journal_title：OncoTargets and therapy

authors： Yi F,Du J,Ni W,Liu W

更新日期：2017-02-20 00:00:00

abstract：Aim:The use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy...

journal_title：OncoTargets and therapy

authors： Xu R,Xu C,Liu C,Cui C,Zhu J

更新日期：2018-12-04 00:00:00

abstract：Introduction:Melanoma has been reported as the most common malignancy in skin cancer. The small nucleolar RNA host gene 5 (SNHG5), an lncRNA, has been proven as a vital regulator in several types of carcinoma. This study was designed to investigate the detailed roles and possible mechanisms of SNHG5 in melanoma progres...

journal_title：OncoTargets and therapy

authors： Gao J,Zeng K,Liu Y,Gao L,Liu L

更新日期：2018-12-24 00:00:00

abstract：BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...

journal_title：OncoTargets and therapy

authors： Chen P,Song Q,Han J,Xu H,Chen T,Xu J,Cheng Y

更新日期：2017-09-27 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...

journal_title：OncoTargets and therapy

authors： Yang P,Xu ZP,Chen T,He ZY

更新日期：2016-04-26 00:00:00

abstract：OBJECTIVE:This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe3O4 (Fe3O4-MNP) and gambogic acid (GA) on SMMC-7721 cells. METHODS:The inhibition of proliferation of SMMC-7721 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assa...

journal_title：OncoTargets and therapy

authors： Tian L,Chen BA,Cheng J,Guo QL

更新日期：2015-08-26 00:00:00

abstract：Background:Investigating the roles of lncRNA prostate cancer-associated transcript 6 (PCAT6) in modulating the growth and aggressiveness of non-small-cell lung carcinoma (NSCLC) cell. Method:The levels of PCAT6 in NSCLC tissues and cell lines were determined by quantitative real-time PCR assay. MTT as well as colony f...

journal_title：OncoTargets and therapy

authors： Cui LH,Xu HR,Yang W,Yu LJ

更新日期：2018-11-01 00:00:00

abstract：:High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metasta...

journal_title：OncoTargets and therapy

authors： Na N,Si T,Huang Z,Miao B,Hong L,Li H,Qiu J,Qiu J

更新日期：2016-11-22 00:00:00

abstract：Background:Growing evidence suggests that miR-150 plays an inhibitory role in various types of cancer. However, the function and underlying mechanisms of miR-150 in triple-negative breast cancer (TNBC) remain unknown. Patients and methods:miR-150 expression was detected by qRT-PCR and ISH in TNBC tumor and adjacent no...

journal_title：OncoTargets and therapy

authors： Tang W,Xu P,Wang H,Niu Z,Zhu D,Lin Q,Tang L,Ren L

更新日期：2018-04-24 00:00:00

abstract：:Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...

journal_title：OncoTargets and therapy

authors： Li X,Zhang Z,Liu J,Wang D,Wei S,Chen J

更新日期：2018-02-09 00:00:00

abstract：PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...

journal_title：OncoTargets and therapy

authors： Boselli C,Renzi C,Gemini A,Castellani E,Trastulli S,Desiderio J,Corsi A,Barberini F,Cirocchi R,Santoro A,Parisi A,Redler A,Noya G

更新日期：2013-01-01 00:00:00

abstract：:CXCL12 (also named SDF1), a member of the chemokine family, has been demonstrated to play an important role in the progression of multiple types of hematological malignancy. Several recent studies have shown that SDF1-3'A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but publi...

journal_title：OncoTargets and therapy

authors： Zhang X,Fan Y,Li Z

更新日期：2017-03-14 00:00:00