Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression.

abstract：Background:With the purpose of elevating the risk of cholangiocarcinoma (CCA), alcoholic liver disease (ALD) was shown. Nonetheless, the findings were controversial. Herein, a meta-analysis and a systematic review were conducted to study the relation as mentioned above. Methods:This study searched PubMed, EMBASE, and ...

journal_title：OncoTargets and therapy

authors： Xiong J,Yin Z,Xu W,Shen Z,Li Y,Lu X

更新日期：2018-11-20 00:00:00

abstract：Background:Breast cancer (BC) has been the commonest malignant tumor with a low survival rate among woman. Long non-coding RNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) was correlated with various cancers. Purpose:The study aimed to investigate the roles and related underlying molecular mechanisms o...

journal_title：OncoTargets and therapy

authors： Guo X,Lee S,Cao P

更新日期：2019-01-24 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S196910.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2019-09-19 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：:Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...

journal_title：OncoTargets and therapy

authors： Li X,Zhang Z,Liu J,Wang D,Wei S,Chen J

更新日期：2018-02-09 00:00:00

abstract：:Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncog...

journal_title：OncoTargets and therapy

authors： Yang F,Zhang C,Xu C,Fu F,Han D,Li H

更新日期：2019-06-05 00:00:00

abstract：:Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radio...

journal_title：OncoTargets and therapy

authors： Burdick MJ,Macklis RM

更新日期：2009-02-18 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...

journal_title：OncoTargets and therapy

authors： Gullapalli S,Remon J,Hendriks LEL,Lopes G

更新日期：2020-07-14 00:00:00

abstract：:CXCL12 (also named SDF1), a member of the chemokine family, has been demonstrated to play an important role in the progression of multiple types of hematological malignancy. Several recent studies have shown that SDF1-3'A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but publi...

journal_title：OncoTargets and therapy

authors： Zhang X,Fan Y,Li Z

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Considerable interest is directed toward the enzyme aromatase (CYP19A1) and the development of cancer, due to CYP19A1's role in estrogen biosynthesis. Several cancers display excessive intra-tumor accumulation of estrogens, and aromatase inhibitors are used for treatment. The CYP19A1 gene exhibits polymorphi...

journal_title：OncoTargets and therapy

authors： Al-Mukaynizi FB,Alanazi M,Al-Daihan S,Parine NR,Almadi M,Aljebreen A,Azzam N,Alharbi O,Arafah M,Warsy A

更新日期：2017-09-14 00:00:00

abstract：:Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...

journal_title：OncoTargets and therapy

authors： Zhao F,Ge YZ,Zhou LH,Xu LW,Xu Z,Ping WW,Wang M,Zhou CC,Wu R,Jia RP

更新日期：2017-11-22 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...

journal_title：OncoTargets and therapy

authors： Bimonte S,Barbieri A,Cascella M,Rea D,Palma G,Del Vecchio V,Forte CA,Del Prato F,Arra C,Cuomo A

更新日期：2018-01-03 00:00:00

abstract：:Lung cancer has the highest morbidity and mortality in the world, and non-small cell lung carcinomas (NSCLC) account for 80% of cases of lung cancer. The mechanism of NSCLC is still largely unknown, and finding novel targets is of great importance for the treatment of NSCLC. The current study was designed to evaluate ...

journal_title：OncoTargets and therapy

authors： He M,Xue Y

更新日期：2017-03-02 00:00:00

abstract：Background:As a component of the EIF3 complex, EIF3C is essential for several steps in protein synthesis initiation. Recently, it has been addressed that EIF3C is overexpressed in several human cancers and plays a pivotal role in cell proliferation and tumorigenesis. Materials and methods:Immunohistochemistry, quantit...

journal_title：OncoTargets and therapy

authors： Gao W,Hu Y,Zhang Z,Du G,Yin L,Yin Z

更新日期：2019-02-14 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：:Background: During the past decades, great efforts have been built to develop lung cancer vaccines. Whole tumor cell lysate (TCL) are ideal sources of antigens for cancer vaccine design, which however have limited efficacy due to insufficient immunogenicity. Recently, radiotherapy has been closely related to immunothe...

journal_title：OncoTargets and therapy

authors： Luo L,Lv M,Zhuang X,Zhang Q,Qiao T

更新日期：2019-05-16 00:00:00

abstract：:Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pr...

journal_title：OncoTargets and therapy

authors： Yu D,Ye T,Xiang Y,Shi Z,Zhang J,Lou B,Zhang F,Chen B,Zhou M

更新日期：2017-09-25 00:00:00

abstract：:Recently, "ipilimumab," an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. "CTLA-4" is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is able to remove the CTL...

journal_title：OncoTargets and therapy

authors： Della Vittoria Scarpati G,Fusciello C,Perri F,Sabbatino F,Ferrone S,Carlomagno C,Pepe S

更新日期：2014-02-19 00:00:00

abstract：:The chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) axis plays an important role in tumorigenesis, metastasis, and recurrence of tumors. Its single nucleotide polymorphisms (SNPs) are associated with patient survival in several types of cancer. However, the prognostic value of SNPs in nasopharyngeal carcinoma ...

journal_title：OncoTargets and therapy

authors： Chen R,Xu Y,Du X,Liu N,Li Y,He Q,Tang L,Mao Y,Sun Y,Chen L,Ma J

更新日期：2015-10-08 00:00:00

abstract：Background:The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma. Patients and methods:A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (ge...

journal_title：OncoTargets and therapy

authors： Nie Y,Liu H,Tan X,Wang H,Li F,Li C,Han P,Lyv X,Xu X,Guo M

更新日期：2019-01-10 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...

journal_title：OncoTargets and therapy

authors： Li C,Li W,Zhang Y,Zhang X,Liu T,Zhang Y,Yang Y,Wang L,Pan H,Ji J,Wang C

更新日期：2018-07-10 00:00:00

abstract：Background:Sesquiterpene lactones are plant-derived, natural, bioactive molecules often used against inflammatory diseases in traditional Chinese medicines. Recently, sesquiterpene lactones have been reported to exhibit potent anticancer activity. In the present study, we have investigated the anticancer activity of Br...

journal_title：OncoTargets and therapy

authors： Wang J,Li M,Cui X,Lv D,Jin L,Khan M,Ma T

更新日期：2018-10-16 00:00:00

abstract：Background:Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer...

journal_title：OncoTargets and therapy

authors： Zou YF,Rong YM,Chen ZX,Shen ZH,Chen X,Tan YX,Weng JR,Huang XM,Lin XT

更新日期：2020-08-26 00:00:00

abstract：Objective:This study aims to uncover the progression of thyroid carcinoma influenced by the m6A methyltransferase METTL3 through regulating m6A methylation on TCF1 mRNA and the activated Wnt pathway. Methods:Thyroid carcinoma tissues and paracancerous ones were collected for detecting levels of METTL3 and TCF1. Potent...

journal_title：OncoTargets and therapy

authors： Wang K,Jiang L,Zhang Y,Chen C

更新日期：2020-02-21 00:00:00

abstract：:Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...

journal_title：OncoTargets and therapy

authors： Zhou F,Chen X,Fan S,Tai S,Jiang C,Zhang Y,Hao Z,Zhou J,Shi H,Zhang L,Liang C

更新日期：2015-04-10 00:00:00

abstract：:Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...

journal_title：OncoTargets and therapy

authors： Kourie HR,El Rassy E,Clatot F,de Azambuja E,Lambertini M

更新日期：2017-07-10 00:00:00

abstract：Objective:The biological functions and molecular mechanisms of miR-935 have been widely investigated in various types of cancer. The aim of the present study was to explore the function of miR-935 in glioma. Methods:Bioinformatic analysis and quantitative real-time fluorescent PCR (qRT-PCR) were used to determine the ...

journal_title：OncoTargets and therapy

authors： Huang G,Chen J,Liu J,Zhang X,Duan H,Fang Q

更新日期：2020-10-23 00:00:00