Update on the rational use of tositumomab and iodine-131 tositumomab radioimmunotherapy for the treatment of non-Hodgkin's lymphoma.

abstract：Objective:As an epidermal growth factor, receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib demonstrates a good therapeutic effect in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). However, an overwhelming majority of these patients inevitably develop resistance against gefitinib. Unfortunately, th...

journal_title：OncoTargets and therapy

authors： Zhang D,Han LL,Du F,Liu XM,Li J,Wang HH,Song MH,Li Z,Li GY

更新日期：2019-11-18 00:00:00

abstract：Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...

journal_title：OncoTargets and therapy

authors： Rao C,Nie L,Miao X,Xu Y,Li B,Zhang T

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...

journal_title：OncoTargets and therapy

authors： Hu QC,Mei X,Feng Y,Ma JL,Yang ZZ,Shao ZM,Yu XL,Guo XM

更新日期：2015-11-04 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer an...

journal_title：OncoTargets and therapy

authors： Liu Y,Guo Z,Zhao C,Li X,Liu H,Chen J

更新日期：2018-08-31 00:00:00

abstract：Background:The global Phase III LUX-Lung 8 trial (ClinicalTrials.gov: NCT01523587) identified significant improvements in progression-free survival (PFS), overall survival (OS), and patient-reported outcomes (PROs) with second-line afatinib vs erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lun...

journal_title：OncoTargets and therapy

authors： Lu S,Li W,Zhou C,Hu CP,Qin S,Cheng G,Feng J,Wang J,Cseh A,Peil B,Gibson N,Ehrnrooth E,Zhang L

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...

journal_title：OncoTargets and therapy

authors： Wang H,Yu J,Li L

更新日期：2015-10-23 00:00:00

abstract：Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...

journal_title：OncoTargets and therapy

authors： Auliac JB,Guisier F,Bizieux A,Assouline P,Bernardini M,Lamy R,Justeau G,François G,Damotte D,Chouaïd C

更新日期：2020-12-30 00:00:00

abstract：Objective:We aimed to determine the safety and efficacy of irreversible electroporation (IRE) combined with chemotherapy for unresectable pancreatic carcinoma (stage III/IV). Methods:We prospectively enrolled 54 patients (30 men; median age 61.0 years; range 41-73 years) undergoing IRE with or without chemotherapy for...

journal_title：OncoTargets and therapy

authors： Liu S,Qin Z,Xu J,Zeng J,Chen J,Niu L,Xu M

更新日期：2019-02-18 00:00:00

abstract：Background:miR520a-3p has previously had its antitumorigenic role in various types of cancers revealed, and been predicted as a posttranscriptional regulator of the NFκB-subunit RELA gene. Thus, miR520a-3p could function in carcinogenesis through suppressing RELA. Methods:Expression of miR520a-3p and RELA mRNA was qua...

journal_title：OncoTargets and therapy

authors： Zhang JQ,Hong B

更新日期：2019-08-14 00:00:00

abstract：Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...

journal_title：OncoTargets and therapy

authors： Liang C,Yue C,Liang C,Ge H,Wei Z,Li G,Wu J,Huang H,Guo J

更新日期：2019-10-30 00:00:00

abstract：:Despite improvements in multidisciplinary treatments, survival of pancreatic cancer (PC) patients remains dismal. Studies dealing with early onset pancreatic cancer (EOPC) patients are scarce. In this review, we discuss differences between EOPC and late-onset pancreatic cancer based on findings in original papers and ...

journal_title：OncoTargets and therapy

authors： Primavesi F,Stättner S,Schlick K,Kiesslich T,Mayr C,Klieser E,Urbas R,Neureiter D

更新日期：2019-05-06 00:00:00

abstract：Purpose:This study aimed to explore significant genes and pathways involved in the pathogenesis of supratentorial primitive neuroectodermal tumor (sPNET). Materials and methods:Gene expression profile of GSE14295 was downloaded from publicly available Gene Expression Omnibus (GEO) database. Differentially expressed ge...

journal_title：OncoTargets and therapy

authors： Wang GY,Li L,Liu B,Han X,Wang CH,Wang JW

更新日期：2018-04-04 00:00:00

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:According to the relevant reports, TIMP-2 polymorphism might be associated with the susceptibility to gastric cancer. Owing to the inconclusive results from the published studies based on the association between TIMP-2 single nucleotide polymorphisms (SNPs) and gastric cancer susceptibility, a meta-analysis ...

journal_title：OncoTargets and therapy

authors： Yang Y,Xiong Y,Li J,Wu C,Jiang J

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...

journal_title：OncoTargets and therapy

authors： Yue S,Shi H,Han J,Zhang T,Zhu W,Zhang D

更新日期：2016-10-11 00:00:00

abstract：:Primary urethral non-Hodgkin's lymphoma (NHL) is uncommon. This case study reports the case of a 52-year-old woman with a light red mass at the urethral orifice. Her clinical manifestations included frequent urination, urgency, dysuria, and occasionally blood in urine. The tumor was surgically removed, and the patholo...

journal_title：OncoTargets and therapy

authors： Zeng H,Wang J,Deng R,Chen Z

更新日期：2020-12-21 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) can affect tumorigenesis. Data from The Cancer Genome Atlas (TCAG) suggest that LINC02783 is highly expressed in renal cell carcinoma (RCC) and is expected to be a potential biological target. We conducted this study to verify this. Patients and Methods:We conducted this study...

journal_title：OncoTargets and therapy

authors： Han C,Xu B,Zhou L,Li L,Lu C,Yu GP,Liu YS

更新日期：2020-10-09 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：:We report a case of a 68-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed partial response after a single treatment with camrelizumab (PD1 monoclonal antibody). The patient's tumor was positive for programmed cell death ligand 1 (PD-L1) and progressed rapidly after a course of chemotherapy. Fortu...

journal_title：OncoTargets and therapy

authors： Chen Y,Zhang H,Shi J,Wang T

更新日期：2020-12-03 00:00:00

abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...

journal_title：OncoTargets and therapy

authors： Wu SG,Sun JY,Zhou J,Li FY,Lin Q,Lin HX,He ZY

更新日期：2014-02-15 00:00:00

abstract：:Purpose: LncRNA MIR100HG promotes several types of malignancies, while its involvement in other human diseases is unknown. Patients and methods: Our study included 70 patients with LSCC who were diagnosed and treated in the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and T...

journal_title：OncoTargets and therapy

authors： Huang Y,Zhang C,Zhou Y

更新日期：2019-04-17 00:00:00

abstract：Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang H,Xu D,Wu WJ,Chen HD,He L

更新日期：2019-11-07 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...

journal_title：OncoTargets and therapy

authors： Su X,Zhang J,Fu C,Xiao M,Wang C

更新日期：2020-04-21 00:00:00

abstract：:ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...

journal_title：OncoTargets and therapy

authors： Li L,Sun F,Chen X,Zhang M

更新日期：2018-02-14 00:00:00

abstract：OBJECTIVES:Long non-coding RNA (lncRNA) associated with microvascular invasion in hepatocellular carcinoma (MVIH) has been recently reported to act as a predictor for the poor recurrence-free survival of hepatocellular carcinoma (HCC) after hepatectomy. However, the biological role of MVIH in the tumorigenesis of HCC i...

journal_title：OncoTargets and therapy

authors： Shi Y,Song Q,Yu S,Hu D,Zhuang X

更新日期：2015-08-27 00:00:00

abstract：Background:Growth differentiation factor (GDF) acted as a factor that regulated proliferation, apoptosis and differentiation in several tumors. However, the effects of growth differentiation factor (GDF11) in pancreatic cancer remain unclear. Purpose:To investigate the expression and significance of GDF11 in pancreati...

journal_title：OncoTargets and therapy

authors： Liu Y,Shao L,Chen K,Wang Z,Wang J,Jing W,Hu M

更新日期：2018-11-27 00:00:00