STRN-ALK Fusion in Lung Adenocarcinoma with Excellent Response Upon Alectinib Treatment: A Case Report and Literature Review.

abstract：Background:Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal ...

journal_title：OncoTargets and therapy

authors： Wang Y,Hong D,Qian Y,Tu X,Wang K,Yang X,Shao S,Kong X,Lou Z,Jin L

更新日期：2018-11-09 00:00:00

abstract：:Low-grade fetal lung adenocarcinoma (L-FLAC) is an exceptionally rare pulmonary tumor, presenting with unclear histological and molecular features. In particular, the potential driver genes of L-FLAC remain elusive. To date, only five reports have documented genetic aberrations in L-FLAC. In the current study, we desc...

journal_title：OncoTargets and therapy

authors： Liu S,Wang J,Luo X,Li X,Miao Y,Wang L,Li Q,Qiu X,Wang EH

更新日期：2020-07-07 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：:Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...

journal_title：OncoTargets and therapy

authors： Han X,Guo X,Zhang W,Cong Q

更新日期：2019-06-20 00:00:00

abstract：:Background: CD19-directed chimeric antigen receptor (CAR) T cells have substantial benefit in the treatment of patients with B-cell malignancies. However, despite encouraging therapeutic efficiency, there is limited overall response rate when anti-CD19 CAR-T cells are used to treat patients with relapsed and refractor...

journal_title：OncoTargets and therapy

authors： Li S,Xue L,Wang M,Qiang P,Xu H,Zhang X,Kang W,You F,Xu H,Wang Y,Liu X,Yang L,Wang X

更新日期：2019-07-12 00:00:00

abstract：Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...

journal_title：OncoTargets and therapy

authors： Su H,Chang C,Hao J,Xu X,Bao M,Luo S,Zhao C,Liu Q,Wang X,Zhou Z,Zhou H

更新日期：2020-11-11 00:00:00

abstract：OBJECTIVE:Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histo...

journal_title：OncoTargets and therapy

authors： Foroulis CN,Kleontas AD,Tagarakis G,Nana C,Alexiou I,Grosomanidis V,Tossios P,Papadaki E,Kioumis I,Baka S,Zarogoulidis P,Anastasiadis K

更新日期：2016-04-19 00:00:00

abstract：Introduction:Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. However, most studies about DNM3 are observational, and knowledge of the precise molecular mechanism of DNM3 remains limited. Materials and methods:We constructed a PCDH-CMV-MCS-...

journal_title：OncoTargets and therapy

authors： Jiang L,Liang QL,Liang WM,Zhang HJ,Huang J,Yuan GL,Peng XX,Cheng SA,Huang ZG,Zhang XN

更新日期：2018-10-09 00:00:00

abstract：Background:Osteosarcoma (OSA), the most common primary bone malignancy, is characterized by a wide spectrum of complicated pathologies and frequent distal metastasis and causes death in adolescents and young adults worldwide. Antitumor drug treatment strategies include various cytotoxic chemotherapy drugs, while molecu...

journal_title：OncoTargets and therapy

authors： Wang L,En H,Yang L,Zhang Y,Sun B,Gao J

更新日期：2019-08-21 00:00:00

abstract：:Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...

journal_title：OncoTargets and therapy

authors： Gogakos AS,Paliouras D,Asteriou C,Rallis T,Lazopoulos A,Chatzinikolaou F,Zissimopoulos A,Tsavlis D,Tsirgogianni K,Zarogoulidis K,Porpodis K,Tsakiridis K,Pitsiou G,Kioumis I,Karapantzos I,Karapantzou C,Sachpekidis N,Zaro

更新日期：2016-01-18 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...

journal_title：OncoTargets and therapy

authors： Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR

更新日期：2016-10-13 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：:Major advances in the understanding of the pathophysiology of melanoma have led to a new era of melanoma treatment with targeted therapy and immunotherapies. Since 2011, four new classes of medications with unique mechanisms of action have been approved, which allow melanoma to be treated at many different stages in i...

journal_title：OncoTargets and therapy

authors： Sun J,Zager JS,Eroglu Z

更新日期：2018-12-14 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：Background:Growth differentiation factor (GDF) acted as a factor that regulated proliferation, apoptosis and differentiation in several tumors. However, the effects of growth differentiation factor (GDF11) in pancreatic cancer remain unclear. Purpose:To investigate the expression and significance of GDF11 in pancreati...

journal_title：OncoTargets and therapy

authors： Liu Y,Shao L,Chen K,Wang Z,Wang J,Jing W,Hu M

更新日期：2018-11-27 00:00:00

abstract：PURPOSE:This study sought to define the role of adjuvant radiation therapy (RT) for patients with curative intent resection of perihilar cholangiocarcinoma (pCCA). PATIENTS AND METHODS:By using the Surveillance, Epidemiology and End Results (SEER) registry, 1,917 patients with non-metastatic pCCA who underwent surgica...

journal_title：OncoTargets and therapy

authors： Leng KM,Liu YP,Wang ZD,Zhong XY,Liao GQ,Kang PC,Cui YF,Jiang XM

更新日期：2017-04-21 00:00:00

abstract：AIM:To retrospectively evaluate the safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in the treatment of patients with advanced intrahepatic cholangiocarcinoma (ICC). METHODS:All patients treated with ultrasound-guided perc...

journal_title：OncoTargets and therapy

authors： Yang GW,Zhao Q,Qian S,Zhu L,Qu XD,Zhang W,Yan ZP,Cheng JM,Liu QX,Liu R,Wang JH

更新日期：2015-05-26 00:00:00

abstract：Purpose:Bulky non-small cell lung cancer (NSCLC) is difficult to achieve effective local control by conventionally fractionated radiotherapy (CRT). The present work aims to evaluate the safety and efficacy of partial stereotactic ablative boost radiotherapy (P-SABR) in bulky NSCLC. Patients and methods:From December 2...

journal_title：OncoTargets and therapy

authors： Bai Y,Gao XS,Qin SB,Chen JY,Su MM,Liu Q,Qin XB,Ma MW,Zhao B,Gu XB,Xie M,Cui M,Qi X,Li XY

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：Background:Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNP...

journal_title：OncoTargets and therapy

authors： Liu J,Hua RX,Cheng Y,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,Bian J,He J

更新日期：2020-01-15 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S262089.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-11-27 00:00:00

abstract：Background:The relationship of inflammation and tumor is becoming more and more important in the study on the pathogenesis of colorectal cancer. The role of TLR9-mediated immune inflammation reaction in the process is not currently clear. The purpose of the study was to discuss the correlation of TLR9 signal activation...

journal_title：OncoTargets and therapy

authors： Gao C,Qiao T,Zhang B,Yuan S,Zhuang X,Luo Y

更新日期：2018-09-18 00:00:00

abstract：Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...

journal_title：OncoTargets and therapy

authors： He Y,Wang Y,Zhao S,Zhao C,Zhou C,Hirsch FR

更新日期：2018-08-13 00:00:00

abstract：Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-functi...

journal_title：OncoTargets and therapy

authors： Sun J,Liu J,Zhu Q,Xu F,Kang L,Shi X

更新日期：2020-06-30 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) has been proved to be correlated with progression and prognosis in many cancers. However, the significance of FGFR4 in non-small-cell lung cancer (NSCLC) is still not well elucidated. METHODS:In our experiment, we detected FGFR4 expression in 237 samples of NSCLC ...

journal_title：OncoTargets and therapy

authors： Huang HP,Feng H,Qiao HB,Ren ZX,Zhu GD

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：Introduction:Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA) and gene modules or representative biomarkers related to the pathological stage ...

journal_title：OncoTargets and therapy

authors： Zhou XG,Huang XL,Liang SY,Tang SM,Wu SK,Huang TT,Mo ZN,Wang QY

更新日期：2018-05-15 00:00:00

abstract：:MicroRNA-126 (miR-126) has been found to promote angiogenesis, but the underlying mechanisms are still unclear. So, we conducted this study to explore the effect of miR-126 expression on angiogenesis in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The expression levels of miR-1...

journal_title：OncoTargets and therapy

authors： Ji JS,Xu M,Song JJ,Zhao ZW,Chen MJ,Chen WQ,Tu JF,Yang XM

更新日期：2016-07-19 00:00:00

abstract：OBJECTIVE:To investigate the impact of surgical resection extent on the postoperative complications and the prognosis in patients with stage II endometrial cancer. METHODS:A total of 54 patients were retrospectively reviewed, 35 patients underwent subradical hysterectomy and 19 patients received radical hysterectomy, ...

journal_title：OncoTargets and therapy

authors： Yin H,Gui T

更新日期：2016-02-16 00:00:00

abstract：:Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...

journal_title：OncoTargets and therapy

authors： Song XY,Li BY,Zhou EX,Wu FX

更新日期：2016-08-26 00:00:00