Decitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma.

abstract：PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...

journal_title：OncoTargets and therapy

authors： Chen J,Li H,Pang R,Huang J

更新日期：2017-04-06 00:00:00

abstract：:ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...

journal_title：OncoTargets and therapy

authors： Li L,Sun F,Chen X,Zhang M

更新日期：2018-02-14 00:00:00

abstract：Background:Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therapy is usually at high intensity, and contact or even invasive electrodes are typically used, which may cause unwanted side effects. ...

journal_title：OncoTargets and therapy

authors： Lu CH,Lin SH,Hsieh CH,Chen WT,Chao CY

更新日期：2018-08-10 00:00:00

abstract：Objective:Growing epidemiological evidence supports that coagulation cascades and cancer-associated inflammation are associated with recurrence and survival of epithelial ovarian cancer (EOC). This study aimed to assess the clinical significance of the combination of plasm fibrinogen and neutrophil lymphocyte ratio (F-...

journal_title：OncoTargets and therapy

authors： Yang J,Ma J,Cheng S,Wang Y

更新日期：2020-07-27 00:00:00

abstract：Background:Several intracellular signaling pathways that are deregulated during hepatocarcinogenesis might constitute potential targets for hepatocellular carcinoma (HCC) therapy. The aim of this study was to test the potential synergic antitumor effect of salirasib and sorafenib in a diethylnitrosamine (DEN)-induced H...

journal_title：OncoTargets and therapy

authors： Ciccarelli O,Colson A,De Saeger C,Reding R,Sempoux C,Leclercq IA,Stärkel P

更新日期：2018-10-17 00:00:00

abstract：:[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2017-04-27 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：:CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

journal_title：OncoTargets and therapy

authors： Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

更新日期：2020-09-22 00:00:00

abstract：:[This retracts the article DOI: 10.2147/OTT.S232594.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-10-07 00:00:00

abstract：OBJECTIVE:Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantatio...

journal_title：OncoTargets and therapy

authors： Ocal N,Yildiz B,Karadurmus N,Dogan D,Ozaydin S,Ocal R,Ozturk M,Arpaci F,Bilgic H

更新日期：2016-12-09 00:00:00

abstract：Background:Leukemia related protein 16 (LRP16), one of the genes belonging to the macro domain family, has been found up-regulated in various tumors including testicles, ovaries and mucosa of colon and is associated with poor clinical outcomes. Purpose:The objective of this study was to investigate expression pattern ...

journal_title：OncoTargets and therapy

authors： Mo Z,Hu M,Yu F,Shao L,Fan K,Jiao S

更新日期：2018-03-05 00:00:00

abstract：Purpose:This study aimed to investigate the regulatory roles of estrogen receptor beta (ERβ) on gastric cancer (GC) cells, and reveal the potential mechanisms relating to nuclear factor-kappa B (NF-κB) signaling. Methods:GC cell lines SGC7901 and MKN45 were transfected with pEGFP-C1-ERβ to overexpress ERβ, and treated...

journal_title：OncoTargets and therapy

authors： Zhang Y,Wu Y,Zhou X,Yi B,Wang L

更新日期：2019-11-05 00:00:00

abstract：Background and objective:Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored. Th...

journal_title：OncoTargets and therapy

authors： Hou Y,Lan C,Kong Y,Zhu C,Peng W,Huang Z,Zhang C

更新日期：2019-03-01 00:00:00

abstract：:Ocular sebaceous carcinoma (SC) is an exceedingly rare but aggressive malignancy that can impair patients' visual acuity or even cause tumor-specific mortality. This tumor usually mimics chronic benign eyelid lesions, thus leading to delayed diagnosis, thereby causing high recurrence and metastasis. Ophthalmologists s...

journal_title：OncoTargets and therapy

authors： Xu Y,Li F,Jia R,Fan X

更新日期：2018-06-27 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer p...

journal_title：OncoTargets and therapy

authors： Zhao L,Zheng Y,Ji Y,Zhang X

更新日期：2019-01-30 00:00:00

abstract：Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...

journal_title：OncoTargets and therapy

authors： Du X,Wang T,Wang Z,Wu X,Gu Y,Huang Q,Wang J,Xie J

更新日期：2020-03-09 00:00:00

abstract：:The association between polymorphic CAG repeats in the androgen receptor gene in women and breast cancer susceptibility has been studied extensively. However, the conclusions regarding this relationship remain conflicting. The purpose of this meta-analysis was to identify whether androgen receptor CAG repeat lengths w...

journal_title：OncoTargets and therapy

authors： Mao Q,Qiu M,Dong G,Xia W,Zhang S,Xu Y,Wang J,Rong Y,Xu L,Jiang F

更新日期：2015-08-13 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...

journal_title：OncoTargets and therapy

authors： Wang Z,Zhang C,Chang J,Tian X,Zhu C,Xu W

更新日期：2020-07-21 00:00:00

abstract：OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...

journal_title：OncoTargets and therapy

authors： Gong X,Wu J,Wu J,Liu J,Gu H,Shen H

更新日期：2017-01-10 00:00:00

abstract：Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...

journal_title：OncoTargets and therapy

authors： Li C,Li W,Zhang Y,Zhang X,Liu T,Zhang Y,Yang Y,Wang L,Pan H,Ji J,Wang C

更新日期：2018-07-10 00:00:00

abstract：Background:The inflammatory indexes are attracting increasing attention as a prognostic predictor for colorectal cancer (CRC). However, the prognostic value of the preoperative lymphocyte-to-C-reactive protein ratio (LCR) in patients with non-metastatic CRC remains to be established. Methods:A total of 955 patients fr...

journal_title：OncoTargets and therapy

authors： Ou W,Zhou C,Zhu X,Lin L,Xu Q

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...

journal_title：OncoTargets and therapy

authors： Van Pham P,Vu NB,Duong TT,Nguyen TT,Truong NH,Phan NL,Vuong TG,Pham VQ,Nguyen HM,Nguyen KT,Nguyen NT,Nguyen KG,Khat LT,Van Le D,Truong KD,Phan NK

更新日期：2012-01-01 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：:Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...

journal_title：OncoTargets and therapy

authors： Qi T,Dong Y,Gao Z,Xu J

更新日期：2020-12-08 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) has been proved to be correlated with progression and prognosis in many cancers. However, the significance of FGFR4 in non-small-cell lung cancer (NSCLC) is still not well elucidated. METHODS:In our experiment, we detected FGFR4 expression in 237 samples of NSCLC ...

journal_title：OncoTargets and therapy

authors： Huang HP,Feng H,Qiao HB,Ren ZX,Zhu GD

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) is identified to be overexpressed in several cancers. However, the role of MALAT-1 in chondrosarcoma is poorly understood. METHODS:The expression of MALAT-1 and Notch-1 signaling pathway was detected in chondrosarcoma tissues and chondrosarcom...

journal_title：OncoTargets and therapy

authors： Xu F,Zhang ZQ,Fang YC,Li XL,Sun Y,Xiong CZ,Yan LQ,Wang Q

更新日期：2016-04-13 00:00:00

abstract：:Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...

journal_title：OncoTargets and therapy

authors： Kourie HR,El Rassy E,Clatot F,de Azambuja E,Lambertini M

更新日期：2017-07-10 00:00:00