Initial Therapy of Advanced Anaplastic Thyroid Cancer via Targeting VEGFR-2: A Case Report.

abstract：Purpose:B7 homologue 6 (B7-H6) has been found at an up-regulated level in multiple cancer cells and identified to be positively correlated with inferior clinical features. In non-Hodgkin lymphoma (NHL), however, the roles of B7-H6 and the underlying mechanism of action remain unclear. Through in vivo and in vitro exper...

journal_title：OncoTargets and therapy

authors： Yang S,Yuan L,Wang Y,Zhu M,Wang J,Ke X

更新日期：2020-06-18 00:00:00

abstract：Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...

journal_title：OncoTargets and therapy

authors： Bayramov B,Gunes S,Buyukalpelli R,Aydın O,Henkel R

更新日期：2018-07-19 00:00:00

abstract：Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...

journal_title：OncoTargets and therapy

authors： Yuan G,Cheng X,Li Q,Zang M,Huang W,Fan W,Wu T,Ruan J,Dai W,Yu W,Chen M,Guo Y,Hu X,Chen J

更新日期：2020-12-09 00:00:00

abstract：PURPOSE:Subsets of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon subtypes. We evaluated the efficacy of first-generation EGFR-tyrosine kinase inhibitors (TKIs; erlotinib, gefitinib, and icotinib) in patients with non-small-cell lung cancer carrying insertions ...

journal_title：OncoTargets and therapy

authors： Chen D,Song Z,Cheng G

更新日期：2016-07-08 00:00:00

abstract：Background:Erlotinib is a commonly used molecular-targeted drug for the treatment of tongue cancer. However, the development of acquired resistance to erlotinib hampers its therapeutic use. Materials and methods:To analyze the erlotinib resistance, long-term and short term survival assay were used to compare the resis...

journal_title：OncoTargets and therapy

authors： Huang K,Liu D

更新日期：2018-09-05 00:00:00

abstract：Purpose:This study aimed to explore significant genes and pathways involved in the pathogenesis of supratentorial primitive neuroectodermal tumor (sPNET). Materials and methods:Gene expression profile of GSE14295 was downloaded from publicly available Gene Expression Omnibus (GEO) database. Differentially expressed ge...

journal_title：OncoTargets and therapy

authors： Wang GY,Li L,Liu B,Han X,Wang CH,Wang JW

更新日期：2018-04-04 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that the clock gene PER1 regulates various tumor-related genes. Abnormal expressions and circadian rhythm alterations of PER1 are closely related to carcinogenesis. However, the dynamic circadian variations of PER1 and tumor-related genes at different stages of carcinogenesis...

journal_title：OncoTargets and therapy

authors： Ye H,Yang K,Tan XM,Fu XJ,Li HX

更新日期：2015-06-11 00:00:00

abstract：:Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...

journal_title：OncoTargets and therapy

authors： Gogakos AS,Paliouras D,Asteriou C,Rallis T,Lazopoulos A,Chatzinikolaou F,Zissimopoulos A,Tsavlis D,Tsirgogianni K,Zarogoulidis K,Porpodis K,Tsakiridis K,Pitsiou G,Kioumis I,Karapantzos I,Karapantzou C,Sachpekidis N,Zaro

更新日期：2016-01-18 00:00:00

abstract：Background:The global Phase III LUX-Lung 8 trial (ClinicalTrials.gov: NCT01523587) identified significant improvements in progression-free survival (PFS), overall survival (OS), and patient-reported outcomes (PROs) with second-line afatinib vs erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lun...

journal_title：OncoTargets and therapy

authors： Lu S,Li W,Zhou C,Hu CP,Qin S,Cheng G,Feng J,Wang J,Cseh A,Peil B,Gibson N,Ehrnrooth E,Zhang L

更新日期：2018-11-30 00:00:00

abstract：Purpose:Strategies to increase radiosensitivity are urgently needed. Combining radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment. Some preclinical studies showed that sepantronium bromide (YM155) could sensitize cancer cells to radiation by inhibiting the survivin protein. In thi...

journal_title：OncoTargets and therapy

authors： Liu X,Zhao Y,Zhang W,Gao Y,Huo M,Liu M,Xiao Z,Liang S,Xu N,Zhu H

更新日期：2018-05-24 00:00:00

abstract：PURPOSE:One of the most challenging aspects of breast carcinoma chemotherapy is the rapid acquirement of drug resistance. Improving the sensitivity to chemotherapeutic drugs is very important for successful treatment. Mus81 plays an important role in maintaining the stability of the genome and DNA repair. However, rece...

journal_title：OncoTargets and therapy

authors： Qian Y,Liu Y,Yan Q,Lv J,Ni X,Wu Y,Dong X

更新日期：2014-10-21 00:00:00

abstract：Background:The diagnosis rate of early stage esophageal squamous cell carcinoma (ESCC) is low due to the lack of specific tumor markers. Seeking for these markers is beneficial to improve the early diagnosis rate and the prognosis of patients. This study profiles the differentially expressed proteins of early stage ESC...

journal_title：OncoTargets and therapy

authors： Tong Q,Wang XL,Li SB,Yang GL,Jin S,Gao ZY,Liu XB

更新日期：2018-09-12 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...

journal_title：OncoTargets and therapy

authors： Wu W,Wang X,Shan C,Li Y,Li F

更新日期：2018-08-20 00:00:00

abstract：Background and aim:Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with n...

journal_title：OncoTargets and therapy

authors： Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR

更新日期：2017-11-10 00:00:00

abstract：PURPOSE:This study aims to investigate the prognostic value of pretreatment C-reactive protein/albumin ratio (CAR) in human malignancies by an updated meta-analysis. METHODS:PubMed, Web of Science, Cochrane Library and Wanfang databases were searched. Pooled hazard ratios (HRs) and odds ratios (ORs) with their corresp...

journal_title：OncoTargets and therapy

authors： Xu HJ,Ma Y,Deng F,Ju WB,Sun XY,Wang H

更新日期：2017-06-19 00:00:00

abstract：Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

journal_title：OncoTargets and therapy

authors： Zhou W,Wang L,Miao Y,Xing R

更新日期：2018-03-19 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：:Purpose: Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients are still comparatively low. Therefore, potential therapeutic targets are urgently needed to improve the survival of lung cancer patients. In t...

journal_title：OncoTargets and therapy

authors： Sun H,Liu K,Huang J,Sun Q,Shao C,Luo J,Xu L,Shen Y,Ren B

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain. PATIENTS AND METHODS:In this retrosp...

journal_title：OncoTargets and therapy

authors： Teng Y,Wang Z,Ma L,Zhang L,Guo Y,Gu M,Wang Z,Wang Y,Yue W

更新日期：2016-07-07 00:00:00

abstract：Background:Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNP...

journal_title：OncoTargets and therapy

authors： Liu J,Hua RX,Cheng Y,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,Bian J,He J

更新日期：2020-01-15 00:00:00

abstract：Background:Circular RNAs (circRNAs) are a special class of noncoding RNAs that are involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of circRNAs in cancer, especially breast cancer (BC), are poorly understood. Materials and Methods:The expression levels of circRNA 0001073 (circ-1073)...

journal_title：OncoTargets and therapy

authors： Yi Z,Li Y,Wu Y,Zeng B,Li H,Ren G,Wang X

更新日期：2020-06-29 00:00:00

abstract：Purpose:To evaluate the association between tertiary Gleason pattern 5 (TGP5) and biochemical recurrence (BCR) in patients with prostate cancer (PCa) with a Gleason score (GS) of 7 after radical prostatectomy (RP). Patients and methods:This retrospective study identified 350 patients who received RP and were graded as...

journal_title：OncoTargets and therapy

authors： Li J,Guo Y,Qiu S,He M,Jin K,Zheng X,Tu X,Liao X,Yang L,Wei Q

更新日期：2019-09-02 00:00:00

abstract：Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...

journal_title：OncoTargets and therapy

authors： Tian J,Xue W,Yin H,Zhang N,Zhou J,Long Z,Wu C,Liang Z,Xie K,Li S,Li L,Wu Z,Daria V,Zhao Y,Wang F,Wang M

更新日期：2020-06-25 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：Background:miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective:This study aimed to analyze the expression profile of miR-486-5p in tumor ti...

journal_title：OncoTargets and therapy

authors： Zheng X,Xu K,Zhu L,Mao M,Zhang F,Cui L

更新日期：2020-05-28 00:00:00

abstract：:Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The...

journal_title：OncoTargets and therapy

authors： Tarazona N,Navarro L,Cejalvo JM,Gambardella V,Pérez-Fidalgo JA,Sempere A,Navarro S,Cervantes A

更新日期：2015-05-14 00:00:00

abstract：Purpose:The TRMT12 is a novel oncogene involved in breast cancer. However, the association between TRMT12 and head and neck squamous cell carcinoma (HNSCC) remains unclear. Materials and methods:The levels of TRMT12 mRNA in HNSCC and normal tissues were analyzed using data from the Cancer Genome Atlas-HNSC. The expres...

journal_title：OncoTargets and therapy

authors： Wang K,Zheng M,Ren Y

更新日期：2019-09-05 00:00:00

abstract：OBJECTIVES:Talimogene laherparepvec is the first oncolytic immunotherapy to receive approval in Europe, the USA and Australia. In the randomized, open-label Phase III OPTiM trial (NCT00769704), talimogene laherparepvec significantly improved durable response rate (DRR) versus granulocyte-macrophage colony-stimulating f...

journal_title：OncoTargets and therapy

authors： Harrington KJ,Andtbacka RH,Collichio F,Downey G,Chen L,Szabo Z,Kaufman HL

更新日期：2016-11-16 00:00:00

abstract：Background:Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysregulated in tumors and critical for tumor-cell proliferation a...

journal_title：OncoTargets and therapy

authors： Li X,Zhu G,Yao X,Wang N,Hu R,Kong Q,Zhou D,Long L,Cai J,Zhou W

更新日期：2018-12-11 00:00:00