Abstract:
Purpose:The TRMT12 is a novel oncogene involved in breast cancer. However, the association between TRMT12 and head and neck squamous cell carcinoma (HNSCC) remains unclear. Materials and methods:The levels of TRMT12 mRNA in HNSCC and normal tissues were analyzed using data from the Cancer Genome Atlas-HNSC. The expression of TRMT12 was also determined using quantitative real-time polymerase chain reaction in 165 paired HNSCC and adjacent normal tissues, which were used as the validation cohort. Results:TRMT12 expression was significantly increased in HNSCC tissues versus normal tissues. High TRMT12 expression was significantly associated with human papillomavirus infection, perineural invasion, tumor invasion, lymphatic metastasis, and clinical stage. Moreover, elevated TRMT12 expression was correlated with unfavorable overall survival (hazard ratio [HR]: 1.711, 95% confidence interval [CI]: 1.141-2.567, P=0.009) and recurrence-free survival (HR: 1.648, 95% CI: 1.060-2.563, P=0.027) in HNSCC patients. Conclusion:TRMT12 was significantly upregulated in HNSCC tissues, which may be attributed to both genetic and epigenetic alterations. Increased TRMT12 expression may be involved in the progression and metastasis of HNSCC, and serve as an independent biomarker of poor prognosis in HNSCC with respect to overall survival and recurrence-free survival.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Wang K,Zheng M,Ren Ydoi
10.2147/OTT.S212200subject
Has Abstractpub_date
2019-09-05 00:00:00pages
7269-7279issn
1178-6930pii
212200journal_volume
12pub_type
杂志文章abstract::Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S105587
更新日期:2016-05-20 00:00:00
abstract::Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S145105
更新日期:2017-11-08 00:00:00
abstract::Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S124012
更新日期:2017-02-20 00:00:00
abstract:Background:Leukemia related protein 16 (LRP16), one of the genes belonging to the macro domain family, has been found up-regulated in various tumors including testicles, ovaries and mucosa of colon and is associated with poor clinical outcomes. Purpose:The objective of this study was to investigate expression pattern ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157914
更新日期:2018-03-05 00:00:00
abstract:Purpose:Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247655
更新日期:2020-04-28 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S279998
更新日期:2021-01-05 00:00:00
abstract:PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S127498
更新日期:2017-04-06 00:00:00
abstract:PURPOSE:This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS:A prospective, open-label, single-arm Phase II study (Clinical...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S91586
更新日期:2016-05-05 00:00:00
abstract:BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86743
更新日期:2015-07-10 00:00:00
abstract::Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S95723
更新日期:2016-01-18 00:00:00
abstract:BACKGROUND:Everolimus, an inhibitor of the mammalian target of rapamycin, shows promising antitumor activity when combined with trastuzumab and chemotherapy for human epidermal growth factor receptor-2 (HER2)-positive breast cancer or when combined with endocrine agents for hormone receptor (HR)-positive tumors. Howeve...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S104398
更新日期:2016-07-01 00:00:00
abstract:Background:Insulin-like growth factor binding protein-2 (IGFBP2) levels are significantly increased in the plasma of hepatocellular carcinoma (HCC) patients. However, the correlation between IGFBP2 levels and clinical parameters and the exact role of IGFBP2 in HCC are unclear. In this study, we identified the role and ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S249527
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87778
更新日期:2016-10-11 00:00:00
abstract::Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S122397
更新日期:2017-07-10 00:00:00
abstract:Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S245663
更新日期:2020-07-27 00:00:00
abstract::miRNAs (miRs) are short RNA molecules that are involved in the posttranscriptional regulation of mRNA. The roles of miRs in tumor pathogenesis have only recently become a focus of research. It is becoming increasingly clear that miRs are important regulators of apoptosis, proliferation, invasion, and metastasis in can...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S52730
更新日期:2013-11-18 00:00:00
abstract:INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S104182
更新日期:2016-07-13 00:00:00
abstract:Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157759
更新日期:2018-05-09 00:00:00
abstract::Acute pancreatitis is a rare complication in postoperative colorectal cancer patients after FOLFOX6 (oxaliplatin + calcium folinate +5-FU [5-fluorouracil]) chemotherapy. In this paper, a total of 62 patients with gastrointestinal cancer were observed after the burst of acute pancreatitis. Surgery of the 62 cases of co...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S88857
更新日期:2015-09-11 00:00:00
abstract::N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However, the specific expression and pro- or anti-cancer role ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S283417
更新日期:2020-12-15 00:00:00
abstract:Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230678
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the efficacy of sorafenib in preventing and treating tumor recurrence after liver transplantation in patients with primary hepatic carcinoma exceeding the Milan criteria. METHODS:Thirty patients with primary hepatic carcinoma exceeding the Milan criteria underwent ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S31387
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S132419
更新日期:2017-06-29 00:00:00
abstract::Esophageal carcinoma (EC) is a lethal disease with high morbidity and mortality worldwide, and the incidence has been increasing in recent years. Although the diagnosis and treatment of EC have improved considerably, EC has rapidly progressed in the clinical setting and has a poor prognosis for its metastasis and recu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S103179
更新日期:2016-04-19 00:00:00
abstract:Background:The mortality rate associated with ovarian cancer ranks the highest among gynecological malignancies. However, the cause and underlying molecular events of ovarian cancer are not clear. Here, we applied integrated bioinformatics to identify key pathogenic genes involved in ovarian cancer and reveal potential...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S152238
更新日期:2018-03-15 00:00:00
abstract:Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S256378
更新日期:2020-09-30 00:00:00
abstract::Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S77828
更新日期:2016-08-26 00:00:00
abstract:Background:The relationship of inflammation and tumor is becoming more and more important in the study on the pathogenesis of colorectal cancer. The role of TLR9-mediated immune inflammation reaction in the process is not currently clear. The purpose of the study was to discuss the correlation of TLR9 signal activation...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S174274
更新日期:2018-09-18 00:00:00
abstract::Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S141053
更新日期:2018-08-06 00:00:00
abstract:Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S286169
更新日期:2020-12-09 00:00:00